The relationship of fasting insulin levels to vascular risk factors in a general practice in Northern Ireland

Beatty, O. L.; Atkinson, A. B.; Browne, Jessica L.; Clarke, K; Sheridan, B.; Bell, P. M.

doi:10.1111/j.1365-2796.1994.tb01268.x

Cited by 1 publication

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“…8 The positive associations between insulin and triglyceride, uric acid, haematocrit and heart rate and the inverse associations between insulin and HDL-cholesterol in this study are entirely consistent with a considerable body of data from cross-sectional studies. 9,[22][23][24][25][26][27][28] The most striking association was that seen between insulin and blood glucose, followed by the association with high triglyceride. Hyperuricaemia is also correlated with hyperinsulinaemia and has been shown to be associated with other components of the syndrome.…”

Section: Insulin and Components Of The Metabolic Syndromementioning

confidence: 97%

Hypertension, serum insulin, obesity and the metabolic syndrome

et al. 1998

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Background and aims: In recent years it has been proposed that hypertension is part of a cluster of metabolic risk factors (syndrome X) involving hyperlipidaemia and hyperglycaemia, with hyperinsulinaemia as the common link. This study has investigated: (1) the prevalence of the metabolic syndrome and its component variables and their relationship to body mass index (BMI) and non-fasting insulin levels in a general population; and (2) the distribution and clustering of metabolic variables in normotensives and hypertensives. Methods: Cross-sectional study of 5222 men aged 40-59 years with no history of coronary heart disease (CHD), diabetes mellitus or stroke drawn from general practices in 18 British towns. The men were a subgroup of the 7735 men in the British Regional Heart Study (BRHS) cohort whose baseline non-fasting serum was analysed for insulin, using a specific ELISA method. Main outcome measures: Hyperinsulinaemia, hyperglycaemia, high serum total cholesterol, high triglyceride and hyperuricaemia were defined as the top 20% of the distribution in the 5222 men. Low HDL-cholesterol was defined as the bottom 20%. Results: BMI and non-fasting insulin were both significantly and strongly associated with non-diabetic hyperglycaemia, lipid abnormalities (HDL-cholesterol, triglyceride and total cholesterol) and hyperuricaemia. BMI was strongly associated with hypertension whereas

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