The relationship of haplotype in lactotransferrin and its expression levels in Chinese Han ovarian cancer

Cao, Liang; Zhou, Yanhong; Li, Xin; Yi, Hong

doi:10.1093/abbs/gmr089

Cited by 9 publications

(10 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been demonstrated that lactoferrin displays anti-tumour activity by regulating tumorigenesis [21,22]. Lactoferrin gene polymorphisms have been described in Chinese Han population and were significantly associated with ovarian cancer [23]. CD163 is a haemoglobin scavenger receptor solely expressed in the monocyte-macrophage system and is a mediator against systemic inflammation [24].…”

Section: Introductionmentioning

confidence: 99%

Investigation of human cationic antimicrobial protein-18 (hCAP-18), lactoferrin and CD163 as potential biomarkers for ovarian cancer

et al. 2013

View full text Add to dashboard Cite

BackgroundEpithelial ovarian cancer is one of the leading causes of gynaecological cancer morbidity and mortality in women. Early stage ovarian cancer is usually asymptomatic, therefore, is often first diagnosed when it is widely disseminated. Currently available diagnostics lack the requisite sensitivity and specificity to be implemented as community-based screening tests. The identification of additional biomarkers may improve the diagnostic efficiency of multivariate index assays. The aims of this study were to characterise and compare the ovarian tissue immunohistochemical localisation and plasma concentrations of three putative ovarian cancer biomarkers: human cationic antimicrobial protein-18 (hCAP-18); lactoferrin; and CD163 in normal healthy women and women with ovarian cancer.MethodsIn this case–control cohort study, ovarian tissue and blood samples were obtained from 164 women (73 controls, including 28 women with benign pelvic masses; 91 cancer, including 21 women with borderline tumours). Localisation of each antigen within the ovary was assessed by immunohistochemistry and serum concentrations determined by ELISA assays.ResultsImmunoreactive (ir) hCAP-18 and lactoferrin were identified in epithelial cells, while CD163 was predominately localised in stromal cells. Tissue ir CD163 increased significantly (P<0.05) with disease grade. Median plasma concentrations of soluble (s)CD163 were significantly greater in the cases (3220 ng/ml) than in controls (2488 ng/ml) (P< 0.01). Median plasma concentrations of hCAP-18 and lactoferrin were not significantly different between cases and controls. The classification efficiency of each biomarker (as determined by the area under the receiver operator characteristic curve; AUC) was: 0.67± 0.04; 0.62 ± 0.08 and 0.51 ± 0.07 for sCD163, hCAP-18 and lactoferrin, respectively. When the 3 biomarkers were modelled using stochastic gradient boosted logistic regression, the AUC increased to 0.95 ± 0.03.ConclusionsThe data obtained in this study establishes the localisation and concentrations of CD163, hCAP-18, and lactoferrin in ovarian tumours and peripheral blood. Individually, the 3 biomarkers display only modest diagnostic efficiency as assessed by AUC. When combined in a multivariate index assay, however, diagnostic efficiency increases significantly. As such, the utility of the biomarker panel, as an aid in the diagnosis of cancer in symptomatic women, is worthy of further investigation in a larger phase 2 biomarker trial.

show abstract

Section: Introductionmentioning

confidence: 99%

Investigation of human cationic antimicrobial protein-18 (hCAP-18), lactoferrin and CD163 as potential biomarkers for ovarian cancer

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Zhou et al () suggested that the LTF “A‐G‐G‐T” haplotype (rs1126477, rs1126478, rs2073495 and rs9110) was a protective factor for nasopharyngeal carcinoma and further influenced the expression levels of JNK2 (Zhou, Liu, Yang, Li, & Xu, ). Cao, Zhou, Li, and Yi () showed that the frequency of rs1126477 A allele was higher in 700 ovarian cancer patients than that in the healthy group of 700 cases ( p < 0.01), suggested that rs1126477 is associated with ovarian carcinoma physiological processes in the Chinese population. An in vitro functional study of the association between LTF variants and antimicrobial activity revealed that the lysine residue (AA genotype) at rs1126478 had stronger anti‐ Streptococcus mutans ability than the arginine residue (GG genotype) in saliva ( p = 0.001, RR = 3.6); it also influenced other acid‐producing microbes.…”

Section: Discussionmentioning

confidence: 99%

Lack of association between LTF gene polymorphisms and different caries status in primary dentition

Wang

Qin

2018

Oral Diseases

View full text Add to dashboard Cite

show abstract

“…Two functional polymorphisms within LTF gene, named Thr29Ala and Arg47Lys, were previously associated with an increased susceptibility to periodontitis development ( Velliyagounder et al 2003 , Jordan et al 2005 , Wu et al 2009), dental caries ( Azevedo et al 2010 , Fine et al 2013 ), ovarian cancer ( Cao et al 2011 ), nasopharyngeal carcinoma ( Zhou et al 2012 ), dyslipidaemia ( Moreno-Navarrete et al 2008 ) and coronary artery stenosis ( Videm et al 2012 ). In our study, the Thr29Ala and Arg47Lys polymorphisms were analysed in order to investigate the possible role of these LTF genetic variants on HIV-1 MTCT.…”

Section: Discussionmentioning

confidence: 99%

“…Two nonsynonymous polymorphisms, Thr29Ala and Arg47Lys (rs1126477 and rs1126478, respectively) in the first exon of the LTF gene, resulting in amino acid changes in the mature peptide and located within the strongly basic N-terminal region of the protein, that mediates its antibacterial properties (Shanbacher et al. 1992) have been described as associated with different pathologies, such as periodontitis ( Velliyagounder et al 2003 , Jordan et al 2005 , Wu et al 2009 ), dental caries ( Azevedo et al 2010 , Fine et al 2013 ), ovarian cancer ( Cao et al 2011 ), nasopharyngeal carcinoma ( Zhou et al 2012 ), dyslipidaemia ( Moreno-Navarrete et al 2008 ) and coronary artery stenosis ( Videm et al 2012 ).…”

mentioning

confidence: 99%

Lactotransferrin gene functional polymorphisms do not influence susceptibility to human immunodeficiency virus-1 mother-to-child transmission in different ethnic groups

Zupin

Polesello

Coelho

et al. 2015

Mem. Inst. Oswaldo Cruz

View full text Add to dashboard Cite

Lactotransferrin, also known as lactoferrin, is an iron binding glycoprotein that displays antiviral activity against many different infectious agents, including human immunodeficiency virus (HIV)-1. Lactotransferrin is present in the breast milk and in the female genitourinary mucosa and it has been hypothesised as a possible candidate to prevent mother-to-child HIV-1 transmission. To verify if two functional polymorphisms, Thr29Ala and Arg47Lys, in the lactotransferrin encoding gene (LTF) could affect HIV-1 infection and vertical transmission, a preliminary association study was performed in 238 HIV-1 positive and 99 HIV-1 negative children from Brazil, Italy, Africa and India. No statistically significant association for the Thr29Ala and Arg47Lys LTF polymorphisms and HIV-1 susceptibility in the studied populations was found. Additionally LTF polymorphisms frequencies were compared between the four different ethnic groups.

show abstract

The relationship of haplotype in lactotransferrin and its expression levels in Chinese Han ovarian cancer

Cited by 9 publications

References 33 publications

Investigation of human cationic antimicrobial protein-18 (hCAP-18), lactoferrin and CD163 as potential biomarkers for ovarian cancer

Investigation of human cationic antimicrobial protein-18 (hCAP-18), lactoferrin and CD163 as potential biomarkers for ovarian cancer

Lack of association between LTF gene polymorphisms and different caries status in primary dentition

Lactotransferrin gene functional polymorphisms do not influence susceptibility to human immunodeficiency virus-1 mother-to-child transmission in different ethnic groups

Contact Info

Product

Resources

About