Lack of association between LTF gene polymorphisms and different caries status in primary dentition

Abstract

The LTF rs1126477 and rs1126478 polymorphisms showed no association with the different levels of caries risk in our Chinese paediatric cohort.

Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis

“…The articles had been published from 2008 to 2019. Eleven studies had been conducted on Caucasians [12, 14-16, 18-23, 25], four studies had been conducted on Asians [5,13,17,24], and one on mixed [11] ethnicities. Eleven studies evaluated children [5, 11, 13-16, 18-20, 22, 24], three studies evaluated adults [17,21,23], and two studies evaluated both adults and children [12,25].…”

“…Eleven studies evaluated children [5, 11, 13-16, 18-20, 22, 24], three studies evaluated adults [17,21,23], and two studies evaluated both adults and children [12,25]. Four studies had assessed LTF rs1126478 in 1556 cases and 1106 controls [5,16,20,24]. Five studies had assessed ENAM rs1264848 in 934 cases and 600 controls [11,14,19,22,25].…”

Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: A meta-analysis

“…The articles had been published from 2008 to 2019. Eleven studies had been conducted on Caucasians [12,[14][15][16][17][18][19][20][21][22][23], four studies had been conducted on Asians [5,13,24,25], and one on mixed [11] ethnicities.…”

“…Eleven studies evaluated children [5,11,[13][14][15][16][17][18][19]21,25], three studies evaluated adults [20,22,24], and two studies evaluated both adults and children [12,23]. Four studies had assessed LTF rs1126478 in 1556 cases and 1106 controls [5,16,19,25]. Five studies had assessed ENAM rs1264848 in 934 cases and 600 controls [11,14,18,21,23].…”

Annual review of selected scientific literature: A report of the Committee on Scientific Investigation of the American Academy of Restorative Dentistry

“…Furthermore, host genetics plays a determinant role. Some polymorphisms, such as those found in lactoferrin, a natural antibacterial protein 369 (note: recent research found no association between gene polymorphism and caries in primary teeth 370 ), or in the production of salivary mucins that cover and protect the mucosa and tooth surface, 371 may influence caries susceptibility. If enamel differs in sensitivity to acid, then it may be possible that the microbial challenge required to initiate and propagate caries is not equivalent at all sites.…”