The relationship of hemodynamic parameters of periodontal microvascular bed and lipid peroxidation products in adolescents with arterial hypertension

Kolesnikova, Lyubov; Darenskaya, M. A.; Погодина, Анна; Grebenkina, L. A.; Natyaganova, L. V.; Колесникова, Л. И.; Колесников, С. И.

doi:10.17116/stomat2020990419

Cited by 1 publication

(1 citation statement)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since middle molecular weight molecules are markers of endotoxicosis, a sharp increase in their content indicates the development and generalization of endogenous intoxication. MMWM are also able to block cell receptors by binding to the active centers of the albumin molecule, competing with regulatory peptides, and thus disrupting the process of humoral regulation (Kolesnikova et al 2020). Therefore, the formation of endogenous intoxication syndrome is an important part of the pathogenesis of periodontitis.…”

Section: Discussionmentioning

confidence: 99%

Effects of flavonol quercetin on syndrome of endogenous intoxication in experimental periodontitis

Demkovych¹,

Shcherba²,

Yaremchuk³

et al. 2021

PHAR

View full text Add to dashboard Cite

The article presents the results of study effect of quercetin on the indicators of endogenous intoxication syndrome under conditions of experimental periodontitis. One of the key links in the pathogenesis of any inflammatory disease, including maxillofacial area, is endogenous intoxication, an important pathophysiological mechanism of which is the activation of lipid peroxidation. The experimental animals were treated by intramuscular injections with water-soluble quercetin for 7 days. For further research the blood serum was selected in which was determined the content of middle molecular weight molecules and erythrocyte intoxication index. Excessive lipoperoxidation was accompanied by accumulation of peroxidation products and depletion of antioxidant reserves, which led to accumulation of toxic substances. That is why the study of the level of middle molecular weight molecules and erythrocyte intoxication index in simulated bacterial-immune periodontitis is a reliable criterion. Quercetin was able to reduce the expression of endogenous intoxication syndrome in experimental bacterial-immune periodontitis.

show abstract

Section: Discussionmentioning

confidence: 99%