The Relationship of Inflammation Parameters with Obstruction in Coronary Artery Ectasia

Abstract

Background: Coronary artery ectasia (CAE) is a coronary artery disease that can progress in a wide clinical spectrum, from asymptomatic cases to stable angina pectoris or acute coronary syndrome. CAE can present with an acute coronary syndrome without an obstructive lesion. Although many studies comparing isolated CAE with normal coronary arteries and coronary artery disease, CAE patients with obstructive type lesions (obstructive CAE) have never been evaluated. In this study, we aimed to compare obstructive CAE patients and isolated CAE patients in terms of various inflammatory parameters. Materials and Methods: A total of 190 patients were enrolled, including 95 obstructive CAE patients and 95 age and sex-matched isolated CAE patients. All participants were evaluated in the study consisted of patients admitted to the emergency department and diagnosed with NSTE-ACS. Systemic inflammatory parameters such as Platelet/lymphocyte ratio (PLR), Neutrophil/lymphocyte ratio (NLR), Monocyte/HDL ratio, CRP and sedimentation of the patients, were compared between two groups. Results: CRP value was found significantly higher in obstructive CAE, compared to isolated CAE [5.5 (3.0-9.0) mg/L, 4.0 (3.0-6.0) mg/L (P=0.003) respectively]. PLR value was found significantly higher in obstructive CAE compared to isolated CAE [143±76, 120±45 (p=0.015) respectively]. In multivariable logistic regression analysis, only CRP was an independent predictor of obstruction in CAE [OR:1.075 (1.011-1.142), p=0.021]. Conclusions: To the best of our knowledge, this study is the first to evaluate the effects of obstructive lesions on inflammatory parameters in patients with CAE presenting with acute coronary syndrome. We have shown that systemic inflammation is increased in the presence of obstructive coronary artery disease in CAE patients.

Yüksek SYNTAXII skoru olan koroner arter hastalarında plazma aterojenik indeksinin rolü

“…Moreover, multivariate logistic regression analysis suggested that AIP can serve as an independent risk agent for CAD, as long as adjusted about age, gender, smoking, HT, family history, DM, serum urea, hemoglobin, serum CRP level, and LVEF (OR: 2.683, %95 CI: 1.552-4.369; P < 0.001). Çerik et al In his study, CRP was found to be significantly higher in obstructive coronary ectasia than in isolated coronary ectasia [30]. CRP, an inflammatory marker, was also found to be statistically significant in our study (p=0.017).…”