The Relationship of Nocturnal Melatonin to Estradiol and Progesterone in Depressed and Healthy Pregnant Women

Posadas, Emerson S.; Meliska, Charles J.; Martı́nez, Leandro; Sorenson, Diane L.; López, Ana M.; Nowakowski, Sara; Hauger, Richard L.; Parry, Barbara L.

doi:10.1089/jwh.2011.3191

Cited by 13 publications

(4 citation statements)

References 43 publications

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“…However, levels of estrogen and progesterone in pregnancy do not differ between women with and without depression . Furthermore, investigations using structural equation modeling have suggested that biological risk factors are more likely to be relevant to postpartum depression than to antenatal depression , which is more strongly related to psychosocial factors.…”

Section: Discussionmentioning

confidence: 99%

Depression precedes, but does not follow, gestational diabetes

Clark

Rasgon

Reed

et al. 2018

Acta Psychiatr Scand

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Objectives To determine whether past history of depression is associated with increased rates of gestational diabetes, and whether history of gestational diabetes is associated with increased rates of postpartum depression. Research design Data for this case–control study consisted of de‐identified chart records for 1439 women who received pregnancy care at a large university hospital between 1998 and 2017. Results A history of depression prior to pregnancy was associated with gestational diabetes requiring insulin, although not with subtler degrees of gestational hyperglycemia. Diabetes in pregnancy was not associated with an increased risk of postpartum depression. Trauma history was associated with both impaired glucose tolerance in pregnancy and postpartum depression. Conclusions Past episodes of depression increase risk for the most severe form of gestational diabetes; however, gestational diabetes does not contribute significantly to risk for postpartum depression. This suggests a unidirectional association, unlike the bidirectional association of diabetes with depression among the general population. History of trauma increases risk for both gestational hyperglycemia and postpartum depression, suggesting important health effects of trauma that may differ measurably from those associated with depression.

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Section: Discussionmentioning

confidence: 99%

Depression precedes, but does not follow, gestational diabetes

Clark

Rasgon

Reed

et al. 2018

Acta Psychiatr Scand

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“…Findings in a study in mice furthermore suggest that melatonin may prevent inflammation-associated preterm delivery [10]. Importantly, melatonin stimulates the production of progesterone, which is essential for the maintenance of pregnancy [11,12].…”

Section: Introductionmentioning

confidence: 99%

Night work during pregnancy and preterm birth—A large register-based cohort study

et al. 2019

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Background Melatonin stimulates the production of progesterone, which is essential for the maintenance of pregnancy. Since melatonin in blood is reduced due to work under illuminated conditions during night work, it has been hypothesized that night work may increase the risk of preterm birth. Previous meta-analyses have not revealed increased risk of preterm birth in women working night shifts during pregnancy. Still, these studies might have been limited by inaccurate self-reports of timing, intensity and duration of night work most likely causing bias towards the null. The aim of this is study was to investigate if the frequency and duration of night work during the first (week 1–12) and second (week 13–22) trimester of pregnancy were associated with risk of preterm birth when objective and prospective data on night work are used. Method In a register-based prospective cohort study, we obtained individual day-to-day information on working hours from The Danish Working Hour Database (DWHD, a payroll database including all public service employees in administrative Danish Regions from 2007–2013) and information on preterm birth from the Danish Medical Birth Registry. Night-shift was defined as at least three working hours between 23:00 and 06:00. Preterm birth was defined as giving birth during gestational weeks 23–37. Odds of preterm birth according to working night shifts were analysed by logistic regression. Results We identified 16,501 pregnant women eligible for the study, of which 10,202 women (61.8%) had at least one night-shift during the first 22 gestational weeks. The risk of preterm birth was not elevated among women working night shifts compared to women working only day shifts during either the first or second trimester. Within night-shift workers, the risk was not related to the number of night shifts, the duration of night shifts, consecutive night shifts or quick returns defined as short intervals between shifts. Odds of preterm birth was not related to change of working schedule from the first to second trimester, although women changing from night shifts in the first trimester to day work only in the second trimester displayed a weak increased odds of preterm birth (OR 1.21, 95%CI 0.98–1.49) compared to women working night shifts in both trimesters. Conclusion Our results, which are without bias from self-report of either exposure or outcome, are in line with the results of previous meta-analyses. Due to the detailed information on hours worked during pregnancy, we were able to investigate several dimensions of night work not previously investigated, of which none were associated with elevated risk of preterm birth.

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“…For example, despite inconsistencies regarding the associations with menstrual cycle phases [12,[14][15][16][17][18][19][20], healthy pregnant women were found with higher melatonin levels than postpartum women [21]. Probably as a consequence of higher gonadal hormone levels, melatonin exposure levels increased with the number of weeks during pregnancy [21] and, contrary to the duration of secretion and the offset timing, positively correlated with oestrogen and progesterone levels [22]. As opposite associations were found in depressed pregnant women, the authors suggested that the sensitivity to the modulating effects of oestradiol on melatonin receptors may be impaired in depression [21,22].…”

Section: Introductionmentioning

confidence: 99%