The relationship of platelet count, mean platelet volume with metabolic syndrome according to the criteria of the American Association of Clinical Endocrinologists: A focus on gender differences

Abstract

Metabolic syndrome (MS) is becoming globally prevalent and it is clinically important because of its association with type 2 diabetes and cardiovascular disease, and some cancers. Recently, platelet count has been linked to insulin resistance and MS in addition to being a marker of hemostasis. Also, mean platelet volume (MPV) has been known to represent platelet activity. Platelet counts and MPV are modified by various biosocial and lifestyle factors such as race, age, gender, smoking habit, alcohol consumption, and physical activity. Thus, the direction and magnitude of this association may differ by gender. In this regard, proper interpretion of platelet counts and MPV by gender could be important in the people with MS. We examined the relationship between platelet counts, MPV, and MS through gender-specific analyses for 3827 Korean adults (2169 men and 1658 women) in a health examination program. In women, platelet counts were significantly higher in subjects with MS compared to in those without MS (p < 0.001), whereas MPV was significantly lower (p = 0.001). However, no such trend was observed in men. Multiple regression analyses also showed that MS is positively associated with platelet counts and inversely associated with MPV, independently of confounding variables only in women. The results suggest that platelet counts and MPV might be a surrogate marker associated with clustered MS in women.

The Relationship between the Plasma PCSK9 Levels and Platelet Indices in Patients with Stable Coronary Artery Disease

“…Animal models with a high cholesterol diet show a significant increase in the PLT count compared to those fed the normal diet 19) . The positive correlation between the PLT count and LDL-C level and multiple metabolic factors reported in population studies suggests a potential link between the PLT count and dyslipidemia 1,2) . Secondly, experimental studies have shown that lipopolysaccharide-induced inflammation stimulates the expression of PCSK9, whereas knockdown of PCSK9 mediated by small-interfering RNA (siRNA) attenuates the ox-LDL-induced expression of proinflammatory genes 20,21) .…”

“…Recently, platelet indices have been receiving increasing attention as possible markers of inflammation and of a greater risk for metabolic disorders and atherogenesis 1,2) . A higher platelet (PLT) count, even within the normal range, has been associated with metabolic syndrome and coronary artery disease (CAD) 1) . In particular, the PLT count has been linked to vascular 3) and non-vascular death, including cancer 4) .…”

Gender differences in the relationship between serum uric acid and mean platelet volume in a Japanese general population

“…Increased MPV is emerging as an independent risk factor for thromboembolism, stroke, and myocardial infarction [1]. MPV of subjects with hypertension [2], dyslipidemia [3], diabetes [4], or metabolic syndrome [4,5] was higher compared with that of the normal controls. Furthermore, MPV was higher than the normal subjects not only in overt diabetic or hypertensive subjects but also in prediabetic [6] or prehypertensive subjects [7].…”

Study of Platelet Indices in Type 2 Diabetic Patients and Its Correlation With Vascular Complications

“…Altered platelet morphology and functions have been linked with the pathological processes and high risk of vascular disease. [3] The platelet indices -(Platelet -PLT, Mean platelet volume -MPV, Platelet distribution width -PDW and Platelet large cell ratio -PLCR) are the determinants of platelet functionality, among which increased mean platelet volume (MPV) and platelet distribution width (PDW) were found to be attributed in the causation of thromboembolic complications. [4,5] It is also noted that the platelets with increased number and size possibly affect the platelet distribution width contributing in the pathogenesis of vascular complications.…”