The relationship of regional cerebral blood flow with subtypes of major depression

Fountoulakis, Kostas N.; Iacovides, Apostolos; Gerasimou, George; Fotiou, Fotis; Ioannidou, Christina; Bascialla, F.; Grammaticos, P.; Kaprinis, George

doi:10.1016/j.pnpbp.2004.01.006

Cited by 64 publications

(43 citation statements)

References 47 publications

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“…All studies compared depressed patients having atypical features with other depressed patients, five including an undifferentiated group having neither melancholic nor atypical features. In all four studies that included patients with melancholic illness, those with atypical features differed (McGinn et al, 1996;Fountoulakis et al, 2004;Bruder et al, 2002;Joyce et al, 2002). In all five studies including an undifferentiated group, those with atypical features differed (McGinn et al, 1996;Anisman et al, 1999;Fountoulakis et al, 2004;Bruder et al, 2002;Joyce et al, 2002).…”

Section: Summary Of Post-dsm-iv Validitymentioning

confidence: 93%

“…Unless atypical depression is differentiated from depressed patients with neither melancholic nor atypical features, applying atypical criteria could be a cumbersome way of saying melancholia is not present. McGinn et al (1996), Anisman et al (1999), Fountoulakis et al (2004), Bruder et al (2002, Stewart et al (1998), andJoyce et al (2002), partially answered the challenge of Parker et al (2002) (see Table 6). All studies compared depressed patients having atypical features with other depressed patients, five including an undifferentiated group having neither melancholic nor atypical features.…”

Section: Summary Of Post-dsm-iv Validitymentioning

confidence: 95%

“…In all four studies that included patients with melancholic illness, those with atypical features differed (McGinn et al, 1996;Fountoulakis et al, 2004;Bruder et al, 2002;Joyce et al, 2002). In all five studies including an undifferentiated group, those with atypical features differed (McGinn et al, 1996;Anisman et al, 1999;Fountoulakis et al, 2004;Bruder et al, 2002;Joyce et al, 2002). One study did not differentiate which patients without atypical depression had melancholia, but did show good imipramine response in those without atypical depression relative to those with atypical depression (Stewart et al, 1998) (see Table 5 for proportions responding).…”

Section: Summary Of Post-dsm-iv Validitymentioning

confidence: 98%

“…Rather, hypercortisolemia may characterize some depressive disorders, but hypocortisolism may be found in others. Fountoulakis et al (2004) investigated single-photon emission computerized tomography (SPECT) in 50 depressed patients with DSM-IV major depression, including subtype assessment. Fountoulakis et al reported perfusion in 17 brain regions (see Table 3).…”

Section: Biological Studiesmentioning

confidence: 99%

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DSM-IV Depression with Atypical Features: Is It Valid?

Stewart

McGrath

Quitkin³

et al. 2009

Neuropsychopharmacol

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Atypical features were incorporated into the American Psychiatric Association's Diagnostic and Statistical Manual, Fourth Edition (DSM-IV, 1994) as an illness specifier for major depression and dysthymia. The validity of depression with atypical features was supported by differences relative to depression with melancholic features in syndromal symptoms, course of illness, biology, family history, and treatment response. This paper reviews post-DSM-IV literature relevant to the validity of depression with atypical features. Most studies support the pre-DSM-IV findings. Again, course of illness, biological, family, and treatment differences are shown between melancholia and depression with atypical features. Several biologic studies report nondepressed controls have mean values between depressed subjects having atypical features and other depressed patients. This suggests atypical depression is a distinct depressive group rather than a milder form of melancholia. In addition, some studies show distinctions between depressed subjects with atypical features and those having neither atypical nor melancholic features. As depression with atypical features separates not only from melancholia but also from other depressed groups and controls over a range of meaningful distinctions, we conclude it is a valid clinical syndrome, useful both heuristically and in driving treatment decisions.

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Section: Summary Of Post-dsm-iv Validitymentioning

confidence: 93%

Section: Summary Of Post-dsm-iv Validitymentioning

confidence: 95%

Section: Summary Of Post-dsm-iv Validitymentioning

confidence: 98%

Section: Biological Studiesmentioning

confidence: 99%

See 2 more Smart Citations

DSM-IV Depression with Atypical Features: Is It Valid?

Stewart

McGrath

Quitkin³

et al. 2009

Neuropsychopharmacol

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“…Finally, both visual memory and problem solving deficits in MEL may depend on an alteration in higher order executive functions, which have been localized in the frontal lobes (central executive system) (Baddeley and Hitch, 1974;Norman and Shallice, 1986). A frontal lobe dysfunction has been consistently associated to both psychotic and melancholic features of depression (Skaf et al, 2002;Garrett et al, 2011;Kelley et al, 2013;Fountoulakis et al, 2004). Furthermore, neuropsychological impairment in processing speed and memory functions have also been associated with hypothalamic-pituitary adrenal (HPA) axis dysregulation (Kino, 2004;Lupien and Lepage, 2001), a feature which has been consistently associated with both melancholic and psychotic MDD (Belanoff et al, 2001;Carroll et al, 1981;Duval et al, 2006;Gomez et al, 2006;Keller et al, 2007;Schatzberg and Rothschild, 1988).…”

Section: Verbal Learning and Memorymentioning

confidence: 99%

A meta-analysis of cognitive performance in melancholic versus non-melancholic unipolar depression

Zaninotto

Solmi

Veronese

et al. 2016

Journal of Affective Disorders

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Increased brain fractional perfusion in obesity using intravoxel incoherent motion (IVIM) MRI metrics

Motger‐Albertí,

de la Calle,

Giménez

et al. 2024

Obesity

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ObjectiveThis research seeks to shed light on the associations between brain perfusion, cognitive function, and mental health in individuals with and without obesity.MethodsIn this study, we employed the noninvasive intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) technique to examine brain fractional perfusion (FP) in two groups: individuals with obesity (N = 72) and healthy controls (N = 66). Additionally, we investigated potential associations between FP, cognitive function, and depressive symptoms in the participants with and without obesity. Finally, artificial intelligence algorithms (Boruta analysis) were also used.ResultsParticipants with obesity exhibited increased FP within dopaminergic brain circuits, particularly involving prefrontal cortex areas, anterior and posterior sections of the cingulate cortex, the right striatum, and the midbrain. Additionally, these individuals demonstrated lower working memory and higher depressive symptoms compared to the control group. Notably, higher FP in the inferior temporal and occipital cortices correlated with greater depressive symptoms, whereas increased FP in the right ventral caudate and the midbrain was associated with better working memory performance. A link between inflammatory and metabolic variables, with a particular emphasis on monocytes, and FP in obesity was also evidenced by Boruta analysis.ConclusionsIncreased brain perfusion in individuals with obesity is associated with cognitive function and mental health through interaction with metabolic and inflammatory factors.

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The relationship of regional cerebral blood flow with subtypes of major depression

Cited by 64 publications

References 47 publications

DSM-IV Depression with Atypical Features: Is It Valid?

DSM-IV Depression with Atypical Features: Is It Valid?

A meta-analysis of cognitive performance in melancholic versus non-melancholic unipolar depression

Increased brain fractional perfusion in obesity using intravoxel incoherent motion (IVIM) MRI metrics

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