The relationship of serum 25-dihydroxy vitamin D3 concentrations with metabolic parameters in non-obese women with polycystic ovarian syndrome

The Effects of Vitamin D on Metabolic Profiles in Women with Polycystic Ovary Syndrome: A Systematic Review

“…1, the main outcomes showed that vitamin D supplementation resulted in beneficial effects on metabolic profiles, including fasting plasma glucose and insulin level, total testosterone, HOMA-IR, hirsutism, and CRP. The seven studies that compared the effect of vitamin D supplementation with placebo, showed significant reductions in the total testosterone (p < 0.001), insulin levels (p = 0.007), hirsutism (p < 0.001), HOMA-IR (p = 0.008), and CRP (p < 0.001) [2,5,7,18,19,21,23]. However, vitamin D supplementation was negatively correlated with the quantitative insulin sensitivity check index (QUICKI) and fasting glucose [20].…”

“…Vitamin D deficiency is common in women with and without PCOS, with 10-60 % of adults having serum levels lower than 20 ng/ ml [2,10]. Accumulating evidence indicates that serum vitamin D may play important roles, such as in enhancing insulin synthesis and release, and increasing insulin receptor expression or suppression of proinflammatory cytokines that possibly contribute to the development of insulin resistance [15].…”

“…Many studies have demonstrated that vitamin D deficiency is common among women with PCOS, with 67-85 % having serum 25-hydroxyvitamin D [25(OH) D] concentrations of 20 < ng/ml (or 50 nmol/l) [5]. Ovulation problems, menstrual irregularities, and infertility are subsequent challenges encountered during the periods of low vitamin D status [2]. Also, vitamin D deficiency is associated with increased insulin resistance and elevated levels of total testosterone and dehydroepiandrosterone sulfate (DHEAS) in patients with PCOS [6,7].…”

“…Although several diagnostic criteria have been reported for PCOS, Rotterdam criteria are known to be the most appropriate and important. In May 2003 a consensus workshop was held in Rotterdam indicated the diagnosis of PCOS was made by the presence of at least two of the following features: irregular or failed ovulation, clinical symptoms, and laboratory findings of hyperandrogenism or the presence of polycystic ovarian morphology confirmed by ultrasonography [2]. Another common characteristic in PCOS patients is insulin resistance, which plays a vital role…”

Lean Women with Polycystic Ovary Syndrome

“…There are some evidences which support this relationship and encourage vitamin D administration in all of deficient PCOs women [69], whereas some studies do not support it [70].…”