The relationship of serum cholesterol and vitamin A in hospitalized patients with and without cancer

Flaim, Evelyn; Williford, William O.; Mullen, James L.; Buzby, Gordon P.; Crosby, Lon O.

doi:10.1093/ajcn/44.3.370

Cited by 12 publications

(7 citation statements)

References 17 publications

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“…There have been many case-control studies showing an inverse relationship between cancer incidence and serum concentrations of vitamin A [6,8,9,15,16]. All of these studies have shown subnormal levels of serum vitamin A in cancer patients compared with the levels of healthy subjects or patients with unspecified non-malignant disease.…”

Section: Discussionmentioning

confidence: 99%

“…There is considerable evidence from case-control studies that a low serum level of vitamin A is an important risk factor for the development of a variety of human cancers of epithelial cell origin [1][2][3][4][5][6][7][8]. Several of these studies [1, [4][5][6]8 ] have also indicated that the presence of an established cancer is associated with low serum concentrations of the vitamin A transport proteins, which include retinol-binding protein (RBP) and prealbumin.…”

mentioning

confidence: 99%

“…Several of these studies [1, [4][5][6]8 ] have also indicated that the presence of an established cancer is associated with low serum concentrations of the vitamin A transport proteins, which include retinol-binding protein (RBP) and prealbumin. Furthermore, in our recent study [9] where serum vitamin A and RBP levels were measured in patients with surgically resected cancers of the colon and rectum, those who subsequently had recurrent disease showed lower levels of vitamin A and RBP compared with those who remained free of recurrence.…”

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confidence: 99%

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Biochemical Status of Vitamin A in Colorectal Cancer.

Basu

Hodgson

Temple

et al. 1991

J. Clin. Biochem. Nutr.

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SummarySerum There is considerable evidence from case-control studies that a low serum level of vitamin A is an important risk factor for the development of a variety of human cancers of epithelial cell origin [1][2][3][4][5][6][7][8]. Several of these studies [1,[4][5][6]8 ] have also indicated that the presence of an established cancer is associated with low serum concentrations of the vitamin A transport proteins, which include retinol-binding protein (RBP) and prealbumin. Furthermore, in our recent study [9] where serum vitamin A and RBP levels were measured in patients with surgically resected cancers of the colon and rectum, those who subsequently had recurrent disease showed lower levels of vitamin A and RBP compared with those who remained free of recurrence. Low RBP levels in plasma have also been reported in patients with recurrence of breast tumors, when compared with the

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Biochemical Status of Vitamin A in Colorectal Cancer.

Basu

Hodgson

Temple

et al. 1991

J. Clin. Biochem. Nutr.

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“…Two animals from each group were humanely killed at 8 hours, 24 hours, 48 hours, 3 days, 6 days, and 12 days after dimethylbenzanthracene application. Buc¬ cal pouches were dissected from each ani¬ mal.…”

Section: Methodsmentioning

confidence: 99%

Vitamins A and E Do Protect Against Oral Carcinoma

Calhoun

Stanley²,

Stiernberg³

et al. 1989

Archives of Otolaryngology - Head and Neck Surgery

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\s=b\ Tumorigenesis requires accelerated polyamine biosynthesis, and elevated levels of ornithine decarboxylase, the rate\x=req-\ limiting enzyme in this reaction chain. The primary goal of this study was to determine whether induction of oral cavity carcinoma by dimethylbenzanthracene was accompanied by increased ornithine decarboxylase. It has previously been demonstrated in an oral carcinogenesis model that cotreatment with vitamins A or E delayed tumor development. The second goal of this study was to determine whether this chemoprotective effect was associated with a decrease in ornithine decarboxylase activity. We found that dimethylbenzanthracene did stimulate ornithine decarboxylase. Vitamins A and E alone also stimulate ornithine decarboxylase, and this effect is additive with dimethylbenzanthracene. Use of both vitamins together prevents the additive effect of either, alone, and vitamin A inhibits the late-phase ornithine decarboxylase response to dimethylbenzanthracene in all animals. We conclude that pretreatment with vitamins A, or A and E together protects against the carcinogenic action of dimethylbenzanthracene, and that the mechanism of this protection is early truncation of the ornithine decarboxylase response to dimethylbenzanthracene.

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“…However, numerous factors, such as stress, infections, and protein-en~rgy malnutrition, are known to depress serum nutrient levels, vitamin A in. particular [5,14,15]. It is therefore important that such factors be controlled by using an appropriate control popu]ation.…”

Section: Introductionmentioning

confidence: 99%

Serum vitamins A and E, beta-carotene, and selenium in patients with breast cancer.

Basu¹,

Hill²,

Ng³

et al. 1989

Journal of the American College of Nutrition

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A total of 89 subjects including 30 breast cancer patients with distal metastases, 29 patients with benign breast disease, and 30 healthy subjects were studied. Serum samples from these subjects were obtained from the National Cancer Institute (NCI) Breast Cancer Serum Bank, Bethesda. Serum concentrations of vitamin A and its transport proteins (prealbumin and retinol-binding protein [RBP]), beta-carotene, vitamin E, and selenium were determined. For each of these parameters the mean for the breast cancer patients was lower than that of the healthy subjects. The differences between healthy subjects and patients with either breast cancer or benign breast disease were, however, statistically significant only in the case of RBP (p less than 0.05). In the case of vitamin A and its transport proteins these differences were reduced by comparing the cancer patients with the benign breast disease patients rather than with the healthy controls. This indicates that the low serum levels for those three parameters may be merely a consequence of disease in general rather than a feature of cancer per se.

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The relationship of serum cholesterol and vitamin A in hospitalized patients with and without cancer

Cited by 12 publications

References 17 publications

Biochemical Status of Vitamin A in Colorectal Cancer.

Biochemical Status of Vitamin A in Colorectal Cancer.

Vitamins A and E Do Protect Against Oral Carcinoma

Serum vitamins A and E, beta-carotene, and selenium in patients with breast cancer.

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