The Relationship of the Renal Excretion of Adrenal Corticoids to Variations in Renal Hemodynamics 1

Marks, Leon J.; Leaf, Alexander; Loon, Kirsten Van

doi:10.1172/jci102797

Cited by 16 publications

(2 citation statements)

References 7 publications

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“…She had been in the hospital on a low sodium diet for a month prior to the study without evidence of change in cardiac function or in the gross edema that was present. During the first part of this study this gross edema (17). That the variation in the urinary aldosterone observed in the present study was due to changes in plasma aldosterone is indicated by two facts.…”

Section: Patients With Cirrhosissupporting

confidence: 59%

The Effect of Changes in Body Sodium on Extracellular Fluid Volume and Aldosterone and Sodium Excretion by Normal and Edematous Men 1

Duncan¹,

Liddle²,

Bartter³

et al. 1956

J. Clin. Invest.

117

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The presence of a sodium-retaining hormone, aldosterone, in the adrenal gland and adrenal venous blood (1-4), the increased urinary excretion of aldosterone during sodium depletion (5, 6) and the inability of men and animals with adrenal insufficiency to conserve sodium support the concept that the process by which the sodium content and thus the extracellular fluid (ECF) volume of the body are regulated includes adrenocortical control of sodium excretion by aldosterone secretion (7).That aldosterone is involved in the formation of edema is indicated by an increased urinary output of this hormone by patients with edema caused by heart failure, portal cirrhosis or nephrosis (8-13).The present work further defines the role of aldosterone in the control of ECF volume of normal men and in the formation of edema by patients with heart failure or portal cirrhosis. METHODSThe patients lived on a metabolic ward during the studies. Constant diets were prepared from uniform lots of food. The patients were weighed each morning after voiding and before breakfast. Blood samples were drawn 3 times a week before breakfast. Total collections of urine and feces were made. Urine was kept at 5°C. during and following collection. Sodium and potassium in diets, urine, feces and sera, and cation exchange resin in feces were determined as previously described (14 (Circulation, 1955, 12, 697).Sodium uptake is thus the percentage of the total exchange capacity of the resin occupied by sodium. The uptake of potassium by resin was calculated in the same fashion on the assumption that there were 10 mEq. of potassium per day uncombined with resin in the stool. The results are essentially the same if it is assumed that all of the sodium and potassium in the stool is combined with resin.

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Section: Patients With Cirrhosissupporting

confidence: 59%

The Effect of Changes in Body Sodium on Extracellular Fluid Volume and Aldosterone and Sodium Excretion by Normal and Edematous Men 1

Duncan¹,

Liddle²,

Bartter³

et al. 1956

J. Clin. Invest.

117

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show abstract

“…(I-c, II-b) in the absence of a large or significant elevation of the urinary "aldosterone" is not explained by the mechanisms considered above. In study I-c the data do not suggest a fall in the glomerular filtration rate which could produce a discordance between urinary and circulating steroids (34). In all of these studies, reductions in the glomerular filtration rate may have occurred which were too small to detect by the method employed and which could have been responsible for significant sodium retention by the kidney (35).…”

Section: Effect Of Acute Hypovolemia On Release Of Aldosteronementioning

confidence: 74%

The Effect of Acute Hypovolemia on the Release of “Aldosterone” and on the Renal Excretion of Sodium1

Fine¹,

Meiselas²,

Auerbach³

1958

J. Clin. Invest.

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Pituitary Adrenal Function and Depression

Fawcett¹

1967

Arch Gen Psychiatry

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The Relationship of the Renal Excretion of Adrenal Corticoids to Variations in Renal Hemodynamics 1

Cited by 16 publications

References 7 publications

The Effect of Changes in Body Sodium on Extracellular Fluid Volume and Aldosterone and Sodium Excretion by Normal and Edematous Men 1

The Effect of Changes in Body Sodium on Extracellular Fluid Volume and Aldosterone and Sodium Excretion by Normal and Edematous Men 1

The Effect of Acute Hypovolemia on the Release of “Aldosterone” and on the Renal Excretion of Sodium1

Pituitary Adrenal Function and Depression

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