The relationships between lipid ratios and arterial stiffness

Mulè, Giuseppe; Nardi, Emilio; Geraci, Giulio; Schillaci, Margherita; Cottone, Santina

doi:10.1111/jch.13030

Cited by 11 publications

(15 citation statements)

References 25 publications

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“…25,26 In light of this relationship, chronic hyperinsulinaemia may increase the local activity of the renin-angiotensin-aldosterone system and the expression of angiotensin II receptors in vascular tissue, ultimately leading to vascular fibrosis and reduced arterial elasticity. 27 Finally, TG/HDL is also regarded as the strongest correlate of small-dense LDL particles rather than larger LDL particles, which are shown to have a greater negative impact on endothelial function than regular LDL particles and may lead to increased arterial stiffness. 27 Findings of the present study may be explained by the involvement of certain pathways.…”

Section: Ta B L Ementioning

confidence: 99%

“…27 Finally, TG/HDL is also regarded as the strongest correlate of small-dense LDL particles rather than larger LDL particles, which are shown to have a greater negative impact on endothelial function than regular LDL particles and may lead to increased arterial stiffness. 27 Findings of the present study may be explained by the involvement of certain pathways. For example, we used PWA of the bra- SVR12 and for one year after DAA treatment.…”

Section: Ta B L Ementioning

confidence: 99%

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Persistent augmentation of central arterial stiffness following viral clearance by direct‐acting antivirals in chronic hepatitis C

Chen

Cheng

Chiu

et al. 2020

Journal of Viral Hepatitis

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Chronic hepatitis C virus (HCV) infection is associated with risk of cardiovascular diseases. Although direct‐acting antivirals (DAA) result in rapid eradication of HCV, their long‐term impact on arterial stiffness remains unclear. This study aimed to evaluate changes in parameters of central arterial stiffness from pretreatment, through sustained virological response, to one year after viral clearance. Patients with chronic HCV receiving DAA treatment were enrolled prospectively. Medical history and comorbidities of all patients were collected. Lipid profiles, liver stiffness by transient elastography and central blood pressures using pulse wave analysis of the brachial artery by cuff sphygmomanometry were measured before treatment, at viral clearance and at one year following viral clearance. Augmentation index (AIx), a parameter of aortic stiffness, was calculated as the ratio of augmentation pressure to central pulse pressure. After DAA treatment, all included patients with chronic HCV (n = 102) had achieved viral clearance. Cholesterol, low‐density lipoprotein (LDL) and triglyceride/high‐density lipoprotein (TG/HDL) increased significantly at viral clearance and persisted at one year (all P < .001). AIx was also elevated significantly at viral clearance and persisted one year later (P < .001). Changes in AIx remained significant only in patients with increased values from baseline in either LDL (P < .01) or TG/HDL (P < .001). Central arterial stiffness and lipid profiles in patients with chronic HCV worsen immediately after viral eradication by DAA treatment and persist at one year. Worsening of lipid profiles after DAA treatment contributes to central arterial stiffness in this patient population and persists long term.

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Section: Ta B L Ementioning

confidence: 99%

Section: Ta B L Ementioning

confidence: 99%

Persistent augmentation of central arterial stiffness following viral clearance by direct‐acting antivirals in chronic hepatitis C

Chen

Cheng

Chiu

et al. 2020

Journal of Viral Hepatitis

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“…It is well known that aging and hypertension are factors that are strongly related to increased arterial stiffness, whereas the correlation between increased arterial stiffness and other established cardiovascular risk factors such as diabetes mellitus, dyslipidemia, renal dysfunction, BMI, and smoking have been shown to be less strong or insignificant [ 41 , 42 , 43 ]. The results in this study concurred with previous findings.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Kidney Stone Disease and Arterial Stiffness in a Taiwanese Population

Sun

Hsiao

Cheng

et al. 2020

JCM

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Previous studies examining the association between kidney stone disease (KSD) and arterial stiffness have been limited. Both age and gender have been found to have an impact on KSD, but their influence on the relationship between KSD and increased arterial stiffness is unclear. This study included 6694 subjects from October 2006 to August 2009. The diagnosis of kidney stone was based on the results of ultrasonographic examination. Increased arterial stiffness was defined as right-sided brachial-ankle pulse wave velocity (baPWV) ≥ 14 m/s. Associations between KSD and increased arterial stiffness were analyzed using multiple logistic regression models. KSD was positively related to increased arterial stiffness in both male and female groups (males: odds ratio [OR], 1.306; 95% confidence interval [CI], 1.035–1.649; females: OR, 1.585; 95% CI, 1.038–2.419) after adjusting for confounding factors. Subgroup analysis by age group (<50 and ≥50 years) showed a significant positive relationship only in the groups ≥ 50 years for both genders (males: OR, 1.546; 95% CI, 1.111–2.151; females: OR, 1.783; 95% CI, 1.042–3.054), but not in the groups < 50 years. In conclusion, KSD is associated with a higher risk of increased arterial stiffness in individuals aged ≥ 50 years, but not in those aged < 50 years for both genders.

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“…TG/HDL-C is also regarded as a strong indicator of increased small dense low-density lipoprotein particles which, compared with larger low-density lipoprotein particles, exhibit a greater negative impact on endothelial stiffness and function and arterial distensibility. [5][6][7][8][9][10] In the current study, the investigators report the use of the METS-IR in a population at risk for CVD correlates with arterial stiffness and is a predictor of incident hypertension. 11 The inclusion of BMI as a surrogate for visceral adiposity in the METS-IR is relevant as recent data support a strong link between adipose tissue remodeling of both visceral fat and perivascular fat in the development of vascular IR and stiffness (Figure 1).…”

Section: Introductionmentioning

confidence: 94%

“…Plasma TG and HDL‐C concentrations are related to insulin‐mediated glucose disposal, and many studies suggest that the TG/HDL‐C ratio provides a simple way to identify individuals who are IR and are at increased cardiometabolic risk. TG/HDL‐C is also regarded as a strong indicator of increased small dense low‐density lipoprotein particles which, compared with larger low‐density lipoprotein particles, exhibit a greater negative impact on endothelial stiffness and function and arterial distensibility …”

mentioning

confidence: 99%

Utility of obesity and metabolic dyslipidemia (a non‐insulin based determinate of the metabolic syndrome and insulin resistance) in predicting arterial stiffness

Aroor

Whaley‐Connell

Sowers

2019

J of Clinical Hypertension

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Increased arterial stiffening is not only a hallmark of the aging process but the consequence of many metabolic abnormalities such as insulin resistance (IR), obesity, and metabolic dyslipidemia. In patients with the cardiometabolic syndrome, arterial stiffening is consistently observed across all age groups. A core feature linking obesity and the metabolic syndrome to arterial stiffness has been IR. However, including other metabolic abnormalities such as metabolic dyslipidemia increases the risk prediction of arterial stiffness in a dose‐dependent fashion. Chronic hyperinsulinemia also increases the activity of both the systemic and the local RAAS which contributes to the development of arterial stiffness. All of these relevant metabolic features that predict arterial stiffness are appropriately incorporated in the METS‐IR used in the current study.

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The relationships between lipid ratios and arterial stiffness

Cited by 11 publications

References 25 publications

Persistent augmentation of central arterial stiffness following viral clearance by direct‐acting antivirals in chronic hepatitis C

Persistent augmentation of central arterial stiffness following viral clearance by direct‐acting antivirals in chronic hepatitis C

Relationship between Kidney Stone Disease and Arterial Stiffness in a Taiwanese Population

Utility of obesity and metabolic dyslipidemia (a non‐insulin based determinate of the metabolic syndrome and insulin resistance) in predicting arterial stiffness

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