The Relationships Between Skeletal Muscle Index and Bone Variables in a Group of Young Adults

Khawaja, Anthony P; Sabbagh, Patchina; Prioux, Jacques; Zunquin, Gautier; Baquet, Georges; Maalouf, Ghassan; Hage, Zaher El; Antoun, Amal; Hage, Rawad El

doi:10.1016/j.jocd.2019.02.007

Cited by 14 publications

(8 citation statements)

References 45 publications

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“…The main variables of our study were that PMI was correlated with BMD throughout the lumbar area and the femoral neck. This is consistent with previous studies finding PMI to be correlated with the volume of skeletal muscle of the whole body and SMI (measured by DXA and BIA) to be correlated with BMD [13À15, 19,20]. The strength of the correlation coefficient between PMI and BMD in this study was similar to the correlation between skeletal muscle mass assessed by BIA and BMD in a previous study [21].…”

Section: Discussionsupporting

confidence: 92%

Psoas muscle index predicts osteoporosis and fracture risk in individuals with degenerative spinal disease

et al. 2022

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Section: Discussionsupporting

confidence: 92%

Psoas muscle index predicts osteoporosis and fracture risk in individuals with degenerative spinal disease

et al. 2022

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“…When adjusted for other confounding factors, TBS positively correlated with relative appendicular skeletal muscle mass 39 . In younger population, another parameter of sarcopenia, skeletal muscle index has been proved to have an effect on TBS, even after adjusting for fat mass 43 …”

Section: Discussionmentioning

confidence: 96%

Factors associated with degraded trabecular bone score in heart transplant recipients

Rakuša

Poglajen

Vrtovec

et al. 2021

Clinical Transplantation

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Trabecular bone score (TBS) is a textural index that provides indirect evaluation of trabecular microarchitecture. It improves fracture risk assessment in several high‐risk populations. We aimed to evaluate the role of TBS assessment in heart transplant recipients (HTR). In a cross‐sectional study with 87 HTR (69 males and 18 females), we assessed TBS and evaluated potential associations between TBS and factors related to increased fracture risk. We also evaluated the correlations between the presence of vertebral fractures (VF) and degraded TBS. We confirmed degraded TBS in the majority of HTR. 27.6% of HTR had partially degraded, 27.6% had degraded TBS. HTR with degraded TBS were older, had higher body mass index, lower bone mineral density (BMD), and T‐score. As opposed to stable BMD over different time points, TBS significantly differed among different post‐transplant time periods. TBS did not correlate with current methylprednisolone or past zoledronic acid treatment, presence of hypogonadism or diabetes. TBS did not have additional value over BMD in predicting the presence of VF. Most fractures occurred in patients with osteopenia and in patients with partly degraded TBS. Studies with longitudinal designs and larger sample sizes are warranted to further assess the potential role of TBS in HRT.

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“…Sarcopenia is highly prevalent in IBD patients and can develop through a variety of mechanisms, including malnutrition, chronic inflammation, increased inflammatory status in adipose tissue, vitamin deficiency and imbalance of the muscle-gut axis [63]. Strategies to increase LM include, among other, physical exercise and this was recently shown to modulate the relationship between muscle and bone density in young people with IBD [64] As for the correlation between ASMI and TBS, the former was an independent positive predictor in young, healthy persons, regardless of gender [65]. Moreover, a similar correlation was found in the elderly, even after adjusting for age, smoking, alcohol and BMI [66].…”

Section: Discussionmentioning

confidence: 99%

Body Composition as a Modulator of Bone Health Changes in Patients with Inflammatory Bowel Disease

Soare

Sîrbu

Popa

et al. 2022

Life

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Background: Bone impairment of multifactorial etiology is a common feature in inflammatory bowel disease (IBD). Body composition parameters, which might be selectively modified in these patients, are important determinants of bone strength. Our aim was to investigate the relationship between components of body composition and bone parameters in IBD patients. Methods: This is a cross-sectional, retrospective study including 80 IBD patients (43 women, 37 men). Lumbar spine (LS), femoral neck (FN) and whole body DXA scans were performed to analyze regional bone mineral density (BMD), as well as body composition, including appendicular skeletal muscle mass index (ASMI), total and visceral fat mass (VAT). Trabecular bone score (TBS) was assessed using iNsight Software. Results: Twenty (25%) IBD patients had inadequate LS-BMD z scores (<=−2DS). Lean mass (LM) was a significant determinant of LS-BMD, after adjusting for age, gender, BMI and fat mass (p < 0.01), while fat mass% remained associated with FN-BMD (p < 0.01). TBS correlated positively with BMI (r = 0.24, p < 0.05), LS-BMD (r = 0.56, p < 0.001), ASMI (r = 0.34, p < 0.001) and negatively with VAT/total fat% (r = −0.27, p < 0.05). Multivariate analysis showed that ASMI, LS-BMD (positively) and VAT/total fat% (negatively) were independently associated with TBS. Conclusions: In IBD patients, skeletal muscle mass and fat percentage and distribution are important factors associated with bone health.

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The Relationships Between Skeletal Muscle Index and Bone Variables in a Group of Young Adults

Cited by 14 publications

References 45 publications

Psoas muscle index predicts osteoporosis and fracture risk in individuals with degenerative spinal disease

Psoas muscle index predicts osteoporosis and fracture risk in individuals with degenerative spinal disease

Factors associated with degraded trabecular bone score in heart transplant recipients

Body Composition as a Modulator of Bone Health Changes in Patients with Inflammatory Bowel Disease

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