The Relative Burden of Dry Eye in Patients’ Lives: Comparisons to a U.S. Normative Sample

Mertzanis, Polyxane; Abetz, Linda; Rajagopalan, Krithika; Espindle, Derek; Chalmers, Robin L.; Snyder, Christopher W.; Caffery, Barbara; Edrington, Timothy B.; Simpson, Trefford; Nelson, J. Daniel; Begley, Carolyn G.

doi:10.1167/iovs.03-0915

Cited by 239 publications

(171 citation statements)

References 13 publications

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“…31,32 Because of the involvement of numerous body tissues in the whole disease process, it is difficult to quantify the relative contribution of dry eye in the compromised quality of life of cGVHD patients. The ongoing debilitating symptoms of severe dry eye, however, would undoubtedly limit the socio-economic functional abilities 33 of a cGVHD dry eye sufferer.…”

Section: Lipid Layer Unstable Stablementioning

confidence: 99%

Tear physiology in dry eye associated with chronic GVHD

Khanal

Tomlinson

2011

Bone Marrow Transplant

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The purpose of this study was to compare tear physiology characteristics of chronic GVHD (cGVHD)-associated dry eye to dry eye caused by Sjogren's syndrome (SS), a extreme form of aqueous-deficient dry eye, and meibomian gland dysfunction (MGD), the major cause of evaporative dry eye. Tear turnover rate, evaporation and osmolarity along with meibomian gland dropout and lipid layer interferometric patterns were assessed in the right eyes of 12 patients with dry eye associated with cGVHD, 12 age-matched patients with SS and 12 age-sex matched subjects with MGD. In cGVHD, the decrease in tear turnover rate was similar (P ¼ 0.33), but the number of non-functioning meibomian glands was significantly higher (Po0.01) than in SS. Tear evaporation rate in cGVHD dry eye was found to be similar to that in MGD (P ¼ 0.36) and significantly higher than in SS (Po0.01). The lipid layer was most unstable in cGVHD compared with other groups. There was no variation in tear volume across all groups. Although statistical significance was not detected, the mean tear osmolarity (333.51± 14.67mOsm/L) was highest in cGVHD. Major aspects of tear physiology were severely impaired in cGVHDassociated dry eye.

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Section: Lipid Layer Unstable Stablementioning

confidence: 99%

Tear physiology in dry eye associated with chronic GVHD

Khanal

Tomlinson

2011

Bone Marrow Transplant

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“…DED causes constant irritation, ocular discomfort, fatigue, and visual disturbance, which interfere with daily activities (Miljanovic et al 2007), disturbing one's ability to perform various tasks that require sustained visual concentration. According to a survey in clinic-based populations, quality of life (QOL), including mental health, was significantly lower in patients with severe DED than in the control group (Mertzanis et al 2005;Le et al 2012;Li et al 2012;Sakane et al 2013). The decrease in QOL caused by DED is an important societal health issue, because this condition results in a larger burden on society through costs of care and treatment, as well as those associated with the disease itself (Lemp et al 2007).…”

Section: Introductionmentioning

confidence: 99%

“…The impact of DED on QOL has been evaluated by several questionnaires (Nichols et al 2002;Mertzanis et al 2005;Kim et al 2011;Le et al 2012;Li et al 2012;Sakane et al 2013). For example, the visual function questionnaire such as the National Eye Institute's Visual Function Questionnaire 25 (NEI VFQ-25) has been used in many studies (Nichols et al 2002;Le et al 2012;Li et al 2012).…”

Section: Introductionmentioning

confidence: 99%

“…For example, the visual function questionnaire such as the National Eye Institute's Visual Function Questionnaire 25 (NEI VFQ-25) has been used in many studies (Nichols et al 2002;Le et al 2012;Li et al 2012). However, few studies have used the 36-Item Short Form Health Survey (SF-36) questionnaire, which is a multi-purpose questionnaire that evaluates mental, physical, and social aspects of QOL (Mertzanis et al 2005), and is considered useful in surveys of general and specific populations, comparing the relative burden between various diseases, and in assessing the health benefits of a specific method of medical treatment (Fukuhara et al 1998a, b;Fukuhara and Suzukamo 2004). SF-36 is capable of evaluating QOL from three aspects by calculating mental, physical, and role/social component summary (MCS, PCS, and RCS) scores from the eight subscale scores based on factor analysis (Fukuhara and Suzukamo 2004).…”

Section: Introductionmentioning

confidence: 99%

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Dry Eye Disease Is Associated with Deterioration of Mental Health in Male Japanese University Staff

Tounaka

Yuki

Kouyama

et al. 2014

Tohoku J. Exp. Med.

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Dry eye disease (DED) is defined as a multifactorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbance, and tear-film instability, with potential damage to the ocular surface. It is thought to be associated with reduced quality of life (QOL). The aim of the present study was to investigate the effects of DED on health-related QOL in Japanese university sedentary office workers who are daily users of visual display terminal. In this study, 163 university staff (99 male and 64 female), aged 23-69 years, served as study subjects. Subjects were asked to answer the following three questions.(1) How often do your eyes feel dry? (2) How often do your eyes feel irritated? (3) Have you ever been diagnosed by a clinician as having dry eye syndrome? Sixty-eight subjects who answered "constantly," "often", or "sometimes" to both questions 1 and 2 were classified as the DED Group, and the remaining 95 were defined as the Non-DED Group. QOL was assessed by the SF-36 questionnaire, which consisted of 36 items to produce three summary scores, namely, mental, physical, and role/social component summary scores. For males, the DED Group had significantly lower scores than the Non-DED Group for mental component summary (MCS) (P = 0.005). In multiple regression analysis, MCS scores were adversely related to DED in males (P = 0.015). DED was associated with worsened QOL. DED should be regarded as a factor that can lead to deterioration of mental health.

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“…Women get more dry-eye symptoms than men (Lin et al 2003). DED has significant impact on the quality of life and daily activities (Mertzanis et al 2005). Currently, the conventional first-line therapy is topical use of artificial tear substitutes which have been found to only relieve symptoms temporarily rather than to treat the underlying cause (Lemp 2008).…”

Section: Introductionmentioning

confidence: 99%

A computerized system of nail-fold capillaroscopy for dry eye disease diagnosis

Hou

Huang

Wang

et al. 2012

Multidim Syst Sign Process

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Nail-fold Capillaroscopy is a convenient and non-invasive tool to evaluate peripheral circulation. Rheumatic diseases such as Raynaud's disease and systemic sclerosis are investigated mostly by nail-fold capillaroscopy. However, it has not been used popularly due to the lack of golden standard in both measurement procedure and objective quantity analysis. This study proposes a computerized system of nail-fold capillaroscopy (CNC). CNC includes standard measurement procedures and three criterions of microcirculation which are capillary density, capillary width and blood flow velocity. CNC is applied to the images of 36 normal subjects and seven patients of dry eye disease (DED). We found density and width of afferent capillary were the better parameters to identify DED ( p < 0.05). CNC could be a good auxiliary diagnostic tool for DED.

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The Relative Burden of Dry Eye in Patients’ Lives: Comparisons to a U.S. Normative Sample

Abstract: These results indicate dry eye's negative impact on everyday life, particularly in daily activities. Further research using disease-specific measures to examine dry eye's impact is underway.

Cited by 239 publications

References 13 publications

Tear physiology in dry eye associated with chronic GVHD

Tear physiology in dry eye associated with chronic GVHD

Dry Eye Disease Is Associated with Deterioration of Mental Health in Male Japanese University Staff

A computerized system of nail-fold capillaroscopy for dry eye disease diagnosis

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