The relative contribution of human cytochrome P450 isoforms to the four caffeine oxidation pathways: An in vitro comparative study with cDNA-expressed P450s including CYP2C isoforms

Kot, Marta; Daniel, W.A.

doi:10.1016/j.bcp.2008.05.025

Cited by 247 publications

(137 citation statements)

References 23 publications

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“…CYP2C8/9 also contributes to the metabolism of caffeine [17] and tamoxifen [16]. CYP2C8*3 genotypes, which may influence CYP2C8 enzyme metabolic activity [38], have previously been associated with a higher risk for early breast cancer events in tamoxifentreated patients, in a subset of the present cohort [21].…”

Section: Discussionmentioning

confidence: 72%

“…The CYP1A2 and CYP2C8 enzymes also contribute to tamoxifen metabolism [15,16] as well as the metabolism of caffeine [17], while SULT1A1 has been proposed to be involved in sulfation of 4-hydroxytamoxifen and may also play a role in endoxifen clearance [13]. In a subset of the present study cohort, it has previously been shown that moderate to high coffee intake modulates ER status in women with the CYP1A2*1F A/A genotype, but not in those with the CYP1A2*1F C-allele [18].…”

Section: Introductionmentioning

confidence: 99%

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Coffee prevents early events in tamoxifen-treated breast cancer patients and modulates hormone receptor status

Simonsson

Söderlind

Henningson

et al. 2013

Cancer Causes Control

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Coffee prevents early events in tamoxifen-treated breast cancer patients and modulates hormone receptor status.Simonsson, Maria; Söderlind, Viktoria; Henningson, Maria; Hjertberg, Maria; Rose, Carsten; Ingvar, Christian; Jernström, Helena General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal Moderate to high coffee consumption was associated with significantly decreased risk for early events in tamoxifen-treated patients and modified hormone receptor status. If confirmed, new recommendations regarding coffee consumption during tamoxifen-treatment may be warranted.

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Section: Discussionmentioning

confidence: 72%

Section: Introductionmentioning

confidence: 99%

Coffee prevents early events in tamoxifen-treated breast cancer patients and modulates hormone receptor status

Simonsson

Söderlind

Henningson

et al. 2013

Cancer Causes Control

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“…semblages with many taxa that are each represented by few individuals (Hammer et al, 2001). Both rarefaction and diversity were calculated in PAST (PAleontologial STatistics, Hammer et al, 2001).…”

Section: Sample Preparation and Pollen Analysismentioning

confidence: 99%

Climate variability and long-term expansion of peatlands in Arctic Norway during the late Pliocene (ODP Site 642, Norwegian Sea)

et al. 2016

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Abstract.Little is known about the terrestrial response of high-latitude Scandinavian vegetation to the warmerthan-present climate of the late Pliocene (Piacenzian, 3.60-2.58 Ma). In order to assess Piacenzian terrestrial climate variability, we present the first high-resolution reconstruction of vegetation and climate change in northern Norway between 3.6 and 3.14 Ma. The reconstructions are derived from pollen assemblages in the marine sediments of ODP Hole 642B, Norwegian Sea (67 • N). The palynological assemblages provide a unique record of latitudinal and altitudinal shifting of the forest boundaries, with vegetation alternating between cool temperate forest during warmerthan-present intervals and boreal forest similar to today during cooler intervals. The northern boundary of the nemoral to boreonemoral forest zone was displaced at least 4-8 • further north, and warmest-month temperatures were 6-14.5 • C higher than at present during warm phases. Warm climatic conditions persisted during the earliest Piacenzian (ca. 3.6-3.47 Ma) with diverse cool temperate nemoral to boreonemoral forests growing in the lowlands of the Scandinavian mountains. A distinct cooling event at ca. 3.47 Ma resulted in a southward shift of vegetation zones, leading to the predominance of boreal forest and the development of open, low alpine environments. The cooling culminated around 3.3 Ma, coinciding with Marine Isotope Stage (MIS) M2. Warmer climate conditions returned after ca. 3.29 Ma, with higher climate variability indicated by the repeated expansion of forests and peatlands during warmer and cooler periods, respectively. Climate progressively cooled after 3.18 Ma, resembling climatic conditions during MIS M2. A high variability of Norwegian vegetation and climate changes during the Piacenzian is superimposed on a long-term cooling trend. This cooling was accompanied by an expansion of Sphagnum peatlands that potentially contributed to the decline in atmospheric CO 2 concentrations at the end of the Piacenzian warm period and facilitated ice growth through positive vegetation-snow albedo feedbacks. Correlations with other Northern Hemisphere vegetation records suggest hemisphere-wide effects of climate cooling.

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“…La comparación de la riqueza de familias observada con la esperada (CHAO2) se realizó con una prueba de bondad de ajuste (Ludwig y Reynolds, 1988). La comparación de la composición de familias de macroinvertebrados acuáticos entre los sitios se realizó mediante un dendrograma (aglomeración por ligamiento promedio bajo el algoritmo UPGMA) a partir de la matriz de disimilitud mediante el índice de BrayCurtis (Ludwig y Reynolds, 1988;Hammer et al 2001;Moreno, 2001). Para el análisis de la calidad hídrica se utilizó el Índice BMWP-Col, de acuerdo a la escala adaptada para Colombia por Roldán (2003).…”

Section: Análisis De Datosunclassified

“…Para el análisis de la calidad hídrica se utilizó el Índice BMWP-Col, de acuerdo a la escala adaptada para Colombia por Roldán (2003). Para determinar si existían diferencias estadísticas en la calidad del agua entre los sitios de muestreo (zona residencial y zona agrícola industrial) de la zona urbana del río Quevedo se empleó una prueba t-Student entre las puntuaciones de cada salida del índice de Calidad BMWP-Col. Todos los análisis se realizaron con un nivel de significancia p=0.05 en el programa Past versión 3 (Hammer et al, 2001).…”

Section: Análisis De Datosunclassified

Macroinvertebrados acuáticos como indicadores de calidad hídrica en áreas de descargas residuales al río Quevedo, Ecuador

Rosado

Yánez

Zambrano

et al. 2017

CyT

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ResumenE l trabajo tuvo como objetivos caracterizar las condiciones físico-químicas del agua, identificar la diversidad de macroinvertebrados bentónicos y determinar la calidad hídrica en dos sitios urbanos de monitoreo del río en la ciudad de Quevedo. Los muestreos se realizaron desde septiembre a noviembre del 2015, en sitios influenciados por descargas de efluentes residenciales (ER) y agrícolas-industriales (EAI). Se midieron los parámetros físico-químicos de calidad del agua: oxígeno disuelto, demanda bioquímica de oxígeno, demanda química de oxígeno y sólidos disueltos totales. Se estimaron los índices de riqueza CHAO2, diversidad de ShannonWeiner (H), dominancia de Simpson (1-D) y disimilitud de Bray-Curtis. La calidad del agua fue estimada con el índice Biological Monitoring Working Party (BMWP-Col). Los valores de los parámetros físico-químicos no presentaron diferencias entre ER y EAI. No existieron diferencias estadísticas entre la riqueza de familias esperada (CHAO2) y la riqueza observada. La familia Tubificidae mostró la mayor abundancia total con 4574 individuos (90.48%), para ER 3918 individuos (93%) y EAI 656 (76%). La diversidad H en ER y EAI fue baja 0.49±0.22; 1.009±0.21 respectivamente, y difirieron significativamente. La dominancia más alta la presentó ER (0.78±0.1), y difirió de EAI (0.58±0.096). El índice BMWP-Col indicó que ER registró calidad de agua "crítica" (20±7.52), en comparación a EAI calidad de agua "dudosa" (37±6.27). El cuerpo hídrico que atraviesa la zona urbana de Quevedo se encontró fuertemente contaminado a causa del urbanismo y las actividades agrícolas e industriales lo que influye negativamente en la estructura de las comunidades de macroinvertebrados acuáticos.Palabras clave: Calidad del agua, río urbano, BMWP-Col, Tubificidae, bioindicadores. AbstractT he objective of this paper was to characterize physical and chemical conditions of water, to identify the diversity of benthic macroinvertebrates, and to determine water quality in two urban monitoring sites of the river in the city of Quevedo. Samplings were carried out from September to November 2015, at sites influenced by residential (RE) and agricultural-industrial (EAI) discharges. Physio-chemical parameters of water quality were measured: dissolved oxygen, biochemical oxygen demand, chemical oxygen demand and total dissolved solids. CHAO2 richness indexes, Shannon-Weiner diversity (H), Simpson dominance (1-D) and BrayCurtis dissimilarity were estimated. Water quality was estimated using the Biological Monitoring Working Party (BMWP-Col) index. The values of the physical-chemical parameters did not show differences between RE and IAS. There were no statistical differences between the expected family richness (CHAO2) and the observed richness. The Tubificidae family showed the highest total abundance with 4574 individuals (90.48%), for ER -3918 individuals (93%), and EAI -656 (76%). H-diversity in ER and IAC was low: 0.49±0.22; 1.009±0.21 respectively, and differed significantly. The highest dominance was shown by ...

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The relative contribution of human cytochrome P450 isoforms to the four caffeine oxidation pathways: An in vitro comparative study with cDNA-expressed P450s including CYP2C isoforms

Cited by 247 publications

References 23 publications

Coffee prevents early events in tamoxifen-treated breast cancer patients and modulates hormone receptor status

Coffee prevents early events in tamoxifen-treated breast cancer patients and modulates hormone receptor status

Climate variability and long-term expansion of peatlands in Arctic Norway during the late Pliocene (ODP Site 642, Norwegian Sea)

Macroinvertebrados acuáticos como indicadores de calidad hídrica en áreas de descargas residuales al río Quevedo, Ecuador

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