2015
DOI: 10.1093/icvts/ivv178
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The relevance of 18F-fluorodeoxyglucose positron emission tomography/computed tomography imaging in diagnosing prosthetic graft infections post cardiac and proximal thoracic aortic surgery

Abstract: PET provides functional data, confirms a CT diagnosis and may even increase diagnostic sensitivity in comparison with CT alone in selected cases. Specificity can be compromised by postoperative changes or chronic inflammatory reactions induced by the graft. CT and/or echocardiography should remain the first diagnostic step in case of a suspected infection because of their broad and fast availability. If confirmation is needed or diagnosis is not achievable using conventional methods, PET might be chosen as the… Show more

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Cited by 29 publications
(43 citation statements)
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“…The results of our study show high sensitivity (95%) and specificity (100%) of 18 F-FDG PET/CT in detection of vascular graft infection, similar to those in the paper of Keidar et al [18], who reported sensitivity of 93% and specificity of 91%, as well in other papers [19,20]. How-ever, specificity may vary, which can be explained by physiological uptake in postoperative inflammation, healing tissue or chronic inflammatory reactions induced by the graft [15,16,21]. 18 F-FDG PET/CT had better diagnostic performance than CT in this study, similar to the results of other studies [4,22].…”
Section: Discussionsupporting
confidence: 88%
See 1 more Smart Citation
“…The results of our study show high sensitivity (95%) and specificity (100%) of 18 F-FDG PET/CT in detection of vascular graft infection, similar to those in the paper of Keidar et al [18], who reported sensitivity of 93% and specificity of 91%, as well in other papers [19,20]. How-ever, specificity may vary, which can be explained by physiological uptake in postoperative inflammation, healing tissue or chronic inflammatory reactions induced by the graft [15,16,21]. 18 F-FDG PET/CT had better diagnostic performance than CT in this study, similar to the results of other studies [4,22].…”
Section: Discussionsupporting
confidence: 88%
“…False-negative finding in one patient was a result of antibiotic therapy used in a period of PET/CT examination. In the study of Guenther et al [16], one patient was also considered false negative for the same reason. Antibiotics reduce inflammation and accumulation of radiopharmaceutical, which can undermine the diagnostic accuracy.…”
Section: Discussionmentioning
confidence: 99%
“…Table 1 summarizes the results of the most recent meta-analyses evaluating [ 18 F]FDG PET/CT in the work-up of VGI [12,38,39]. The most recent one [38] reports a pooled sensitivity of 96%, ranging between 81% [43] and 100% [42,[44][45][46], and a pooled specificity of 74%, ranging between 29% [47] and 92% [48].…”
Section: [ 18 F]fdg Pet/ct Imaging Of Vgimentioning
confidence: 99%
“…This is demonstrated by increased FDG uptake compared to normal tissue. There is currently no consensus on the routine use of 18 F-FDG PET/CT, however, the role of this imaging modality in diagnosing vascular infection has received recent interest. 8 18 F-FDG PET/CT has been shown to have accurate diagnostic powers in aortic vasculitis and infection, 9 but the evidence is limited to small case series and individual case reports.…”
Section: Introductionmentioning
confidence: 99%
“…8 18 F-FDG PET/CT has been shown to have accurate diagnostic powers in aortic vasculitis and infection, 9 but the evidence is limited to small case series and individual case reports. [10][11][12][13] Studies on the use of 18 F-FDG PET/CT in vascular graft infection (VGI) are less well reported but have also shown promising results. [14][15][16][17][18] There are concerns regarding its sensitivity however, particularly in phases of noninfective inflammation of aneurysms and during the early postoperative period after graft placement when inflammatory processes can lead to false-positive readings.…”
Section: Introductionmentioning
confidence: 99%