The Relevance of Assessing the Cell Proliferation Factor Ki-67 in Squamous Cell Carcinoma of the Larynx

Vukelić, Jelena; Dobrila-Dintinjana, Renata; Dekanić, Andrea; Marijić, Blažen; Čubranić, Aleksandar

doi:10.1155/2019/8142572

Cited by 15 publications

(13 citation statements)

References 22 publications

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“…Increased cell proliferation may be an adaptive response to an injurious substance [ 26 ]. However, an important feature of laryngeal malignant transformation is the large number and high proliferation rate of dividing cells [ 27 ]. While CS has been shown to induce laryngeal epithelial hyperplasia [ 28 , 29 ], very few studies have directly investigated proliferating cells in response to CSE.…”

Section: Introductionmentioning

confidence: 99%

Short-term whole body cigarette smoke exposure induces regional differences in cellular response in the mouse larynx

et al. 2021

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Section: Introductionmentioning

confidence: 99%

Short-term whole body cigarette smoke exposure induces regional differences in cellular response in the mouse larynx

et al. 2021

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“… CircABCB10 enhances invasion and migration of LSCC cells. [ 5 ] The AMC-HN-8 and Hep-2 cells were treated with control shRNA or circABCB10 shRNA. ( A and B ) The cell migration and invasion were determined by transwell assays in the cells.…”

Section: Resultsmentioning

confidence: 99%

“…Surgery and radiotherapy are broadly used, and chemotherapy is applied in several curative approaches [ 3 , 4 ]. The high rate of LSCC recurrence is usually caused by chemotherapy resistance and high invasiveness [ 5 , 6 ]. Consequently, it is required for the profoundly comprehend the mechanisms of LSCC progression and carcinogenesis for the development of more efficient therapeutic strategies.…”

Section: Introductionmentioning

confidence: 99%

Circular RNA ABCB10 contributes to laryngeal squamous cell carcinoma (LSCC) progression by modulating the miR-588/CXCR4 axis

Zhao

Wang

et al. 2021

Aging

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Laryngeal squamous cell carcinoma (LSCC) is a common head and neck cancer with a high metastasis and poor prognosis. Circular RNAs (circRNAs) are a type of non-coding RNAs (ncRNAs) with regulatory function and broadly participate in cancer development. However, the correlation of circular RNA ABCB10 (circABCB10) with LSCC remains unclear. Here, we were interested in the role of circABCB10 in the modulation of LSCC progression. Our data demonstrated that the depletion of circABCB10 significantly inhibited the proliferation and induced the apoptosis of LSCC cells. Meanwhile, circABCB10 knockdown was able to remarkably reduce the invasion and migration of LSCC cells. Mechanically, circABCB10 served as a sponge for microRNAs-588 (miR-588) and miR-588 could target and down-regulated chemokine receptor 4 (CXCR4) expression in LSCC cells. The overexpression of CXCR4 or miR-588 inhibitor could reverse circABCB10 depletion-attenuated malignant phenotypes of LSCC cells. Functionally, the depletion of circABCB10 alleviated the tumor growth of LSCC cells in the tumorigenicity analysis of nude mice. The CXCR4 expression was decreased while the miR-588 expression was enhanced by circABCB10 depletion in vivo . Thus, we concluded that circABCB10 was involved in the malignant progression of LSCC by regulating miR-588/CXCR4 axis. Our finding provides new insights into the mechanism of circRHOT1 contributing to the development of LSCC. CircABCB10 and miR-588 may be used as potential targets for the treatment of LSCC.

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“…We first began by assessing ESRP1 protein levels, as well as those of the widely used proliferative index Ki-67 [18], in 44 archived paraffin-embedded human cervical carcinoma tissue samples via immunohistochemical staining (Figure 1). We observed high and low ESRP1 protein levels of 38.6% (17/44) and 61.4% (27/44), respectively.…”

Section: Resultsmentioning

confidence: 99%

ESRP1 Induces Cervical Cancer Cell G1-Phase Arrest Via Regulating Cyclin A2 mRNA Stability

Chen

Jing

et al. 2019

IJMS

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Accumulating evidence indicates that epithelial splicing regulatory protein 1 (ESRP1) can inhibit the epithelial-to-mesenchymal transition (EMT), thus playing a central role in regulating the metastatic progression of tumors. However, it is still not clear whether ESRP1 directly influences the cell cycle, or what the possible underlying molecular mechanisms are. In this study, we showed that ESRP1 protein levels were significantly correlated with the Ki-67 proliferative index (r = −0.521; p < 0.01), and that ESRP1 overexpression can significantly inhibit cervical carcinoma cell proliferation and induced G1-phase arrest by downregulating cyclin A2 expression. Importantly, ESRP1 can bind to GGUGGU sequence in the 3′UTR of the cyclin A2 mRNA, and ESRP1 overexpression significantly decreases the stability of the cyclin A2 mRNA. In addition, our experimental results confirm that ESRP1 overexpression results in enhanced CDC20 expression, which is known to be responsible for cyclin A2 degradation. This study provides the first evidence that ESRP1 overexpression induces G1-phase cell cycle arrest via reducing the stability of the cyclin A2 mRNA, and inhibits cervical carcinoma cell proliferation. The findings suggest that the ESRP1/cyclin A2 regulatory axis may be essential as a regulator of cell proliferation, and may thus represent an attractive target for cervical cancer prevention and treatment.

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The Relevance of Assessing the Cell Proliferation Factor Ki-67 in Squamous Cell Carcinoma of the Larynx

Cited by 15 publications

References 22 publications

Short-term whole body cigarette smoke exposure induces regional differences in cellular response in the mouse larynx

Short-term whole body cigarette smoke exposure induces regional differences in cellular response in the mouse larynx

Circular RNA ABCB10 contributes to laryngeal squamous cell carcinoma (LSCC) progression by modulating the miR-588/CXCR4 axis

ESRP1 Induces Cervical Cancer Cell G1-Phase Arrest Via Regulating Cyclin A2 mRNA Stability

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