The Relevance of IgA Deposits in Vessel Walls of Clinically Normal Skin

Hené, Ronald J.; Velthuis, Peter; Wiel, A. van de; Klepper, D.; Mees, E. J. Dorhout; Kater, L.

doi:10.1001/archinte.1986.00360160177024

Cited by 30 publications

(6 citation statements)

References 22 publications

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“…Moreover, IgA-dominant immune deposits can be observed in most patients with HSP (25), and its presence has been included in the definition adopted by the Consensus Conference on the Nomenclature of Systemic Vasculitides (26). Recently, Helander et a1 (27) have critically assessed the diagnostic utility of vascular deposits of IgA.…”

Section: Discussionmentioning

confidence: 99%

Henoch‐Schönlein purpura in adulthood and childhood. Two different expressions of the same syndrome

Blanco

Martínez‐Taboada

Rodríguez‐Valverde

et al. 1997

Arthritis & Rheumatism

360

176

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Objective.To assess the possible differences between children (120 years) and adults (>20 years) with Henoch-Schonlein purpura (HSP).Methods. A retrospective study of an unselected population of patients with HSP who presented to our teaching hospital between 1975 and 1994. Patients were classified as having HSP according to the criteria proposed by Michel et al.Results. Following the above-mentioned criteria, 162 white patients (113 male and 49 female) were classified as having HSP; 46 of the patients were adults (mean f SD age 53.2 f 16.9 years) and 116 were children (6.9 f 3.1 years). We were unable to identify any precipitating event in 72% of the adults and 66% of the children. The frequency of previous drug treatment, primarily antibiotics or analgesics, was similar in both groups, whereas previous upper respiratory tract infection was more frequent among the children (P < 0.02).At symptom onset, cutaneous lesions were the main clinical manifestation in both groups. However, adults had a lower frequency of abdominal pain (P < 0.008) and fever (P < 0.01), and a higher frequency of joint symptoms (P < 0.001). During the clinical course, adults had more frequent (P < 0.001) and severe renal involvement. An increased erythrocyte sedimentation rate was also more frequent in the adults (P < 0.001).Adults required more aggressive therapy, consisting of steroids (P < 0.002) and/or cytotoxic agents (P < 0.001). The outcome was relatively good in both age groups, with complete recovery in 107 children (93.9%) and in 33 adults (89.2%) after a mean f SD followup of 19.4 2 27.7 (median 12) and 21.8 * 33.5 (median 15) months, respectively.

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Section: Discussionmentioning

confidence: 99%

Henoch‐Schönlein purpura in adulthood and childhood. Two different expressions of the same syndrome

Blanco

Martínez‐Taboada

Rodríguez‐Valverde

et al. 1997

Arthritis & Rheumatism

360

176

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“…(2) Mesangial IgA deposits show a granular pattern and are electrondense when examined by electron microscopy. (3) Deposits of IgA have been detected in blood vessels of extrarenal compartments such as muscles and skin [13][14][15].…”

Section: The First Experimental Model and The Role Of Iga-icmentioning

confidence: 99%

Primary IgA Nephropathy: The Relevance of Experimental Models in the Understanding of Human Disease

Montinaro

Gesualdo²,

Schena³

1992

Nephron

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IgA nephropathy is the most common form of primary glomerulonephritis worldwide. About one quarter of patients progress to terminal renal failure 10 years after the apparent clinical onset. Therefore, the disease represents a social problem in terms of number of patients requiring maintenance hemodialysis. Despite the intense research effort devolved to clarify the pathogenesis of IgA nephropathy, the exact relationship linking the several factors involved is still unknown. In this review we analyze the experimental works reported since 1979, when the first animal model of IgA nephropathy was published by Rifai et al. We also discuss the interplay between experimental data and clinical observations to maximize the information gathered from the different animal models. Finally, we report the new insights into the role played by cytokines, growth factors and autacoids.

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“…[7] 100 2 Hirbec et al [8] 86 14 Lamperi and Carozzi [9] 50 ? Thompson et al [10] 29 28 Rambausek et al [11] 29 28 Zawada and Ramirez [13] 0 15 Hene et al [12] 75 60 This study 0 19…”

mentioning

confidence: 95%

“…Various immune deposits, mainly IgA, have been found in the involved skin of HSP patients [3] who may also show immune deposits in the uninvolved skin [3][4][5]. In the study of Baart de la Faille-Kuyper et al [6] and a few others [7][8][9][10][11][12], however, high levels of IgA positivity were observed in the normal skin in BD which led the investigators to conclude that this finding could be of importance in the diagnosis of some BD cases in whom renal biopsy is either contraindicated or could not be performed. Zawada and Ramirez [13], on the other hand, suggested that these cases should rather be accepted as subclinical or occult HSP, not BD.…”

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confidence: 99%