The relevance of maternal immune responses to inhalant allergens to maternal symptoms, passive transfer to the infant, and development of antibodies in the first 2 years of life

Platts-Mills, Thomas A.E.; Erwin, Elizabeth A.; Allison, Anne; Blumenthal, Kevin; Barr, Marisa; Sredl, Diane; Burge, Harriet A.; Gold, Diane R.

doi:10.1067/mai.2003.10

Cited by 47 publications

(37 citation statements)

References 40 publications

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“…In contrast, the exposure to animal dander at later time points might not derive any protective effect on the immune system and indeed might lead to the development of sensitizations. [43][44][45][46] In a subgroup of children with AD at risk for asthma who display sensitization against aeroallergens, a preventive effect of orally administered antihistamines has been proved in the ETAC study, 47 and this presents another mode of preventive action on the development of AD.…”

Section: Aeroallergensmentioning

confidence: 96%

Immune mechanisms leading to atopic dermatitis

Novak

Bieber

Leung

2003

Journal of Allergy and Clinical Immunology

362

254

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Section: Aeroallergensmentioning

confidence: 96%

Immune mechanisms leading to atopic dermatitis

Novak

Bieber

Leung

2003

Journal of Allergy and Clinical Immunology

362

254

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“…The potential for repercussions from maternally transmitted IgE or IgE immune complexes from breast milk are likely significant in offspring. Interestingly, maternal IgE to cat allergen (76) or maternal history of asthma in conjunction with exposure to cat allergen is associated with increased risk of wheezing in childhood (77).…”

Section: Discussionmentioning

confidence: 99%

Maternal Transmission of Resistance to Development of Allergic Airway Disease

Matson

Zhu

Lingenheld

et al. 2007

The Journal of Immunology

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Parental phenotype is known to influence the inheritance of atopic diseases, such as allergic asthma, with a maternal history being a more significant risk factor for progeny than paternal history. We hypothesized that recall Th1- or Th2-type immune responses during pregnancy would result in transfer of maternal factors that would differentially impact development of immune responsiveness in offspring. Following weaning, susceptibility and severity of allergic airway disease (a murine model of human asthma) was evaluated in progeny, disease being elicited by immunization with OVA-Al(OH)3 and challenge with aerosolized OVA. We found that progeny of mothers with Th1-biased immunity to OVA subjected to recall aerosol challenge during pregnancy had reduced levels of Ag-specific IgE and airway eosinophilia compared with progeny of mothers with Th2-biased immunity to OVA or naive mothers. Interestingly, progeny of mothers with Th1-type immunity to a heterologous albumin, BSA, were not protected from developing OVA-induced allergic airway disease. These findings demonstrated that maternal transfer of protection from development of allergic airway disease to offspring in this model of maternal Th1-type immunity was Ag specific.

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“…The implications of the in utero transfer of IgG to inhalant allergens for asthma development is a subject of active investigation. 8 Also, additional factors such as exposure to cigarette smoke, maternal weight gain during pregnancy, and race/ethnicity may be influential in immune development. 9-14 Improved understanding of cord blood immune responses and an association with maternal in utero influences, such as maternal history of asthma or smoking, may help elucidate the understanding of immune development.…”

Section: Introductionmentioning

confidence: 99%