The Relevance of Serum Cystatin C Level of Different Classification of Atrial Fibrillation

Duan, Yuqing; Xu, Jing; Hu, Wei; Li, Rui

doi:10.4236/ijcm.2019.108033

Cited by 3 publications

(3 citation statements)

References 18 publications

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“…[8][9][10] Since cystatin C levels are thought to be affected by inflammation, it is possible that upregulation of cystatin C in ARDS is not just a consequence of early multiorgan impairment. 7,[15][16][17] However, our study did not enable us to investigate this possibility.…”

Section: Discussionmentioning

confidence: 88%

The relationship between plasma cystatin C, mortality and acute respiratory distress syndrome subphenotype in the HARP-2 trial

McKelvey¹,

Bradbury²,

McDowell³

et al. 2022

Critical Care and Resuscitation

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OBJECTIVE: To evaluate the performance of cystatin C as a prognostic and predictive marker in a trial of patients with acute respiratory distress syndrome (ARDS). DESIGN, PATIENTS AND SETTING: A retrospective analysis was performed on plasma samples from patients included in the HARP-2 (hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in acute lung injury to reduce pulmonary dysfunction) trial — a multicentre, phase 2b trial carried out in general intensive care units across 40 hospitals in the United Kingdom and Ireland. Cystatin C concentrations in plasma obtained from 466 patients with ARDS (before they were randomly assigned in the trial) were quantified by ELISA (enzyme-linked immunosorbent assay). RESULTS: In a univariate analysis, plasma cystatin C concentrations were significantly higher in patients with ARDS who did not survive past 28 days (odds ratio [OR], 1.39 [95% CI, 1.12–1.72]; P = 0.002). In a multivariate model adjusted for selected covariates, cystatin C concentrations remained higher among patients with ARDS who did not survive, although this did not reach statistical significance (OR, 1.28 [95% CI, 0.96–1.71]; P = 0.090). Cystatin C concentration was also significantly associated with hyperinflammatory ARDS (OR, 2.64 [95% CI, 1.83–3.89]; P < 0.001). In multivariate models adjusted for both cystatin C concentration and ARDS subphenotype, hyperinflammatory ARDS was prognostic for mortality (OR, 2.06 [95% CI, 1.16–3.64]; P = 0.013) but cystatin C concentration was not (OR, 1.16 [95% CI, 0.85–1.57]; P = 0.346). In a multivariate analysis, hyperinflammatory ARDS was predictive of a beneficial effect of simvastatin on mortality (OR, 2.05 [95% CI, 1.16–3.62]; P = 0.014) but cystatin C concentration was not (OR, 1.10 [95% CI, 0.77–1.56]; P = 0.614). CONCLUSION: The association between cystatin C concentration and mortality in ARDS may be dependent on inflammatory subphenotype. Cystatin C concentration does not appear to add to existing prognostic or predictive approaches.

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Section: Discussionmentioning

confidence: 88%

The relationship between plasma cystatin C, mortality and acute respiratory distress syndrome subphenotype in the HARP-2 trial

McKelvey¹,

Bradbury²,

McDowell³

et al. 2022

Critical Care and Resuscitation

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show abstract

“…The authors discovered that blood Cys-C and inflammation were linked to AF as a result of our analysis of the relationships between Cys-C and different clinical markers. AF incidence and growth were strongly associated with inflammation, as evidenced by the positive correlations between markers like hypersensitivity protein, white blood cell count, and neutrophil percentage 24 .…”

Section: Cystatin Cmentioning

confidence: 91%

Association Between Biomarkers of Kidney Disorders and Atrial Fibrillation: A Literature Review

Rafaqat,

Sharif

2023

J Cardiac Arrhtythmias

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Kidney diseases and atrial fibrillation often occur together. Renal impairment increases the risk of developing incident atrial fibrillation (AF) and is linked to it in a bidirectional manner, making it a prothrombotic and pro-hemorrhagic condition. In Japanese patients with nonvalvular AF, lower creatinine clearance values were associated with thromboembolism, all-cause death, and cardiovascular death, but not with major haemorrhage. Older individuals with elevated serum levels of cystatin C had a significantly higher prevalence of AF. Moderate to severe chronic kidney disease individuals with increased levels of fibroblast growth factor-23 were independently associated with prevalent and incident AF. A higher baseline glomerular filtration rate was associated with an increased risk of AF. Elevated levels of insulin-like growth factor binding protein-7 were also observed in AF patients, while reduced circulating tissue inhibitor of metalloproteinase 2 levels were also associated with an increased risk of AF. Patients with AF had higher levels of non-esterified fatty acids and liver type fatty acid binding protein. Interleukin-18 levels in blood plasma were also found to be higher in AF patients. Furthermore, higher baseline urea/blood urea nitrogen levels were significantly associated with the incidence of AF in women and kidney disease in both men and women.

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“…All nucleated cells constitutively produce cystatin C, which is found in all body fluids [ 20 ]. In addition to acting as an antiprotease, cystatin C is consistent with several inflammatory markers, such as interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and C-reactive protein [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Activities and concentration of alpha-1 antitrypsin and cystatin C in serum from patients with house dust mite asthma

Hidayati,

Iswanti,

Djauzi

et al. 2023

Asia Pacific Allergy

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Background: The proteolytic activities of house dust mite (HDM) allergens are involved in the pathogenesis of asthma by cleaving T-junction protein complexes, increasing the permeability of airway epithelial cells, and enabling the allergens to reach the interstitial tissue. The human body contains natural protease inhibitors such as alpha-1 antitrypsin (AAT) with antiserine protease activity and cystatin C with anticysteine protease activity. Objective: This study aimed to investigate the behavior of serum AAT and cystatin C levels in patients with HDM-allergic asthma. Methods: Ten individuals with HDM-allergic asthma and 10 healthy volunteers participated in a cross-sectional study. The serum AAT and cystatin C inhibitory activities were measured using enzymatic assays. ELISA was used to determine the serum AAT and cystatin C concentrations. Results: Serum AAT inhibitory activity (P = 0.445; P > 0.05), AAT concentration (P = 0.290; P > 0.05), and cystatin C concentration (P = 0.419; P > 0.05) did not significantly differ between the patient and control groups. However, serum cystatin C inhibitory activity in the asthmatic patient group was significantly higher than in the healthy subjects (P = 0.001; P < 0.05). There was no correlation between AAT inhibitory activity and AAT concentration or between cystatin C inhibitory activity and cystatin C concentration. Conclusion: These findings suggest that serum cystatin C activity is involved in asthma pathogenesis. Additional research is required to address this issue.

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The Relevance of Serum Cystatin C Level of Different Classification of Atrial Fibrillation

Cited by 3 publications

References 18 publications

The relationship between plasma cystatin C, mortality and acute respiratory distress syndrome subphenotype in the HARP-2 trial

The relationship between plasma cystatin C, mortality and acute respiratory distress syndrome subphenotype in the HARP-2 trial

Association Between Biomarkers of Kidney Disorders and Atrial Fibrillation: A Literature Review

Activities and concentration of alpha-1 antitrypsin and cystatin C in serum from patients with house dust mite asthma

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