The remarkably enzyme-rich venom of the Big Bend Scorpion (Diplocentrus whitei)

Nyström, Gunnar; Ellsworth, Schyler A.; Rokyta, Darin R.

doi:10.1016/j.toxicon.2023.107080

Toxicon

2023

DOI: 10.1016/j.toxicon.2023.107080

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The remarkably enzyme-rich venom of the Big Bend Scorpion (Diplocentrus whitei)

Gunnar Nyström

Schyler A. Ellsworth

Darin R. Rokyta

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Cited by 4 publications

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Identification and synthesis of a long‐chain antimicrobial peptide from the venom of the Liocheles australasiae scorpion

Miyashita,

Sakai,

Okabe

et al. 2024

Journal of Peptide Science

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Scorpion venom contains linear peptides without disulfide bonds in addition to peptides with disulfide bonds. Many such linear peptides have an amphiphilic α‐helical structure, often with antimicrobial activity and can be classified into three groups based on their molecular size. Among them, long‐chain antimicrobial peptides consisting of more than 40 residues have not been thoroughly studied due to the difficulty of synthesizing them. We have previously reported a transcriptome analysis of the venom gland of Liocheles australasiae that revealed precursor sequences of long‐chain antimicrobial peptides. In the study reported here, we identified the mature structure of one such long‐chain antimicrobial peptide, LaCT1, which we synthesized using chemical ligation to confirm its structure and evaluate its biological activities. The result showed that LaCT1 exhibited significant antimicrobial activity. In addition, we identified its partial peptides consisting of an N‐ or C‐terminal region, which may be generated by enzymatic cleavage in the venom. Among them, only the peptide containing the N‐terminal half region was active. LaCT1 also not only showed insecticidal activity but also synergistically enhanced the effects of another insecticidal peptide identified in L. australasiae venom as well. These results provide insights into the role of antimicrobial peptides in scorpion venom.

show abstract

Identification and synthesis of a long‐chain antimicrobial peptide from the venom of the Liocheles australasiae scorpion

Miyashita,

Sakai,

Okabe

et al. 2024

Journal of Peptide Science

View full text Add to dashboard Cite

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Varying Modes of Selection Among Toxin Families in the Venoms of the Giant Desert Hairy Scorpions (Hadrurus)

Nystrom,

Ellsworth,

Ward

et al. 2023

J Mol Evol

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Evaluation of Saxifraga stolonifera phenolic extracts as a potential antivenom against Deinagkistrodon acutus venom: In vitro and in vivo studies

Liu¹,

Ye²,

Fang³

et al. 2024

Journal of Ethnopharmacology

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The remarkably enzyme-rich venom of the Big Bend Scorpion (Diplocentrus whitei)

Cited by 4 publications

References 100 publications

Identification and synthesis of a long‐chain antimicrobial peptide from the venom of the Liocheles australasiae scorpion

Identification and synthesis of a long‐chain antimicrobial peptide from the venom of the Liocheles australasiae scorpion

Varying Modes of Selection Among Toxin Families in the Venoms of the Giant Desert Hairy Scorpions (Hadrurus)

Evaluation of Saxifraga stolonifera phenolic extracts as a potential antivenom against Deinagkistrodon acutus venom: In vitro and in vivo studies

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