The Renal Effects of Blood Glucose-Lowering Plant-Derived Extracts in Diabetes Mellitus—an Overview

Mapanga, RF; Musabayane, C T

doi:10.3109/08860220903367585

Cited by 22 publications

(19 citation statements)

References 86 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The liver and kidneys are prime targets because they are involved in the degradation and excretion of a myriad of chemical compounds. Renal damage has been associated with the use of the medicinal plants in the treatment of different disorders, including diabetes mellitus (Mapanga and Musabayane, 2010).…”

Section: Introduction:-mentioning

confidence: 99%

Safety of Ethyl Acetate Fraction of Cocos Nucifera Root Extract.

Sènou¹,

Tchogou²,

Dougnon³

et al. 2017

IJAR

View full text Add to dashboard Cite

1083Cocos nucifera is a tropical coastal plant. The ethyl acetate fraction of its aqueous root extract stimulates erythropoiesis. This work aimed to evaluate the biological tolerance of this fraction. The extract fraction was administered to Wistar rats at a single dose of 2000 mg / kg body weight for Acute Oral Toxicity (OAT) or in daily doses of 200 mg / kg body weight for 28 days for Sub-Chronic Toxicity. (SCT), as recommended by the OECD. On day 0, then on day 14 for OAT and day 28 for SCT, the rats were weighed and their blood was collected for tests. The liver balance was assessed by measuring transaminases AST and ALT, kidney balance by uremia and creatinine level and immune status by blood leukocyte count. These analyzes were supplemented by the histology of the liver, kidneys and spleen, an immune organ. The weight of rats, the balance of liver, kidney and immunity as well as these organs histology were not affected by either acute oral or sub-chronic toxicity tests, suggesting a lack of toxicity in the extract fraction. The ethyl acetate fraction of the root water extract of Cocos nucifera did not reveal any acute or sub-chronic oral toxicity. This effect could be related to its richness in flavonoids that are antioxidants. The study of biological tolerance deserves to be continued by the chronic toxicity test and clinical trials.

show abstract

Section: Introduction:-mentioning

confidence: 99%

Safety of Ethyl Acetate Fraction of Cocos Nucifera Root Extract.

Sènou¹,

Tchogou²,

Dougnon³

et al. 2017

IJAR

View full text Add to dashboard Cite

show abstract

“…Liver and kidney are the first targets in toxicological evaluation because they are involved in the metabolism and excretion of chemical compounds. Renal damage has also been associated with the use of medicinal plants in the treatment of various diseases [12]. …”

Section: Introductionmentioning

confidence: 99%

Toxicological assessment of the hydroethanolic leaf extract of clerodendrum capitatum in wistar rats

Idoh¹,

Agbonon²,

Potchoo³

et al. 2016

Pan Afr Med J

View full text Add to dashboard Cite

IntroductionClerodendrum capitatum (Willd) Schumach. & Thonn (Lamiaceae) is used in African traditional medicine for the treatment of malaria, hypertension, obesity, jaundice and diabetes however there is lack of experimental data on its possible toxicity. This study investigated the acute and 28 days sub-chronic toxicity of C. capitatum in Wistar rats.MethodsIn acute toxicity tests, a single administration of the hydroethanolic C. capitatum leaf extract (5 g/kg) was given orally to 5 female rats. The general behavior, adverse effects and mortality were recorded for up to 14 days post treatment. On the 15th day, the rats were weighed and euthanized for necropsy. In sub-chronic toxicity tests, the extract (4, 8 and 16 g/kg/day) was given orally to both male and female rats for 28 days. The animal body weight was recorded throughout the experiment, while hematological and biochemical parameters of blood and relative organs weights were evaluated on the 29th day.ResultsClerodendrum Capitatum did not cause any death or any hazardous symptoms of acute toxicity, showing an LD50 higher than 5 g/kg. Sub-chronic administration of C. capitatum resulted in no noticeable changes in weight gain and water or food consumption. White blood cells and hemoglobin increased while urea concentration, liver enzymes, total cholesterol and glucose concentrations significantly decreased in treated animals. No changes in macroscopical aspect of organs were observed in the animals.ConclusionThese results showed that acute or sub-chronic oral administration of the hydroethanolic leaf extract of Clerodendrum capitatum may be considered as relatively free of toxicity.

show abstract

“…Research summarised in a recent review15 showed that several southern African plant species used by rural communities as traditional medicines had hypoglycaemic effects in streptozotoc-ininduced (STZ) diabetic rat. Furthermore, some species had antihypertensive properties 16-19.…”

Section: Introductionmentioning

confidence: 99%

The effects of medicinal plants on renal function and blood pressure in diabetes mellitus : review article

Musabayane¹

2012

CVJA

View full text Add to dashboard Cite

Diabetes mellitus is one of the most common chronic global diseases affecting children and adolescents in both the developed and developing nations. The major types of diabetes mellitus are type 1 and type 2, the former arising from inadequate production of insulin due to pancreatic β-cell dysfunction, and the latter from reduced sensitivity to insulin in the target tissues and/or inadequate insulin secretion. Sustained hyperglycaemia is a common result of uncontrolled diabetes and, over time, can damage the heart, eyes, kidneys and nerves, mainly through deteriorating blood vessels supplying the organs. Microvascular (retinopathy and nephropathy) and macrovascular (atherosclerotic) disorders are the leading causes of morbidity and mortality in diabetic patients. Therefore, emphasis on diabetes care and management is on optimal blood glucose control to avert these adverse outcomes.Studies have demonstrated that diabetic nephropathy is associated with increased cardiovascular mortality. In general, about one in three patients with diabetes develops end-stage renal disease (ESRD) which proceeds to diabetic nephropathy (DN), the principal cause of significant morbidity and mortality in diabetes. Hypertension, a well-established major risk factor for cardiovascular disease contributes to ESRD in diabetes. Clinical evidence suggests that there is no effective treatment for diabetic nephropathy and prevention of the progression of diabetic nephropathy. However, biomedical evidence indicates that some plant extracts have beneficial effects on certain processes associated with reduced renal function in diabetes mellitus. On the other hand, other plant extracts may be hazardous in diabetes, as reports indicate impairment of renal function. This article outlines therapeutic and pharmacological evidence supporting the potential of some medicinal plants to control or compensate for diabetes-associated complications, with particular emphasis on kidney function and hypertension.

show abstract

The Renal Effects of Blood Glucose-Lowering Plant-Derived Extracts in Diabetes Mellitus—an Overview

Cited by 22 publications

References 86 publications

Safety of Ethyl Acetate Fraction of Cocos Nucifera Root Extract.

Safety of Ethyl Acetate Fraction of Cocos Nucifera Root Extract.

Toxicological assessment of the hydroethanolic leaf extract of clerodendrum capitatum in wistar rats

The effects of medicinal plants on renal function and blood pressure in diabetes mellitus : review article

Contact Info

Product

Resources

About