The Renal Handling of Protein 1 (Clara Cell Protein): Effect of Age, Sex and Renal Dysfunction

Bernard, Alfred; Vandeleene, Bernard; Thielemans, N.; Lauwerys, Robert; Lambert, André

doi:10.1159/000422110

Cited by 21 publications

(13 citation statements)

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“…The majority of the female subjects had low U-CC16, which has been observed previously (Bernard et al, 1993;Timonen et al, 2004). The high CC16 levels among some men may be explained by some CC16 originating from the prostate even after discarding the first 100 ml.…”

Section: Discussionmentioning

confidence: 53%

“…The high CC16 levels among some men may be explained by some CC16 originating from the prostate even after discarding the first 100 ml. The excretion of U-CC16 in male subjects increases with age, probably due to an increase in postrenal excretion (Bernard et al, 1993), but after discarding the first 100 ml, no similar association between age and U-CC16 excretion was found. As mentioned above, the excretion rate of CC16 has a diurnal variation.…”

Section: Discussionmentioning

confidence: 85%

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Methodological aspects on measurement of Clara cell protein in urine as a biomarker for airway toxicity, compared with serum levels

Andersson

Lundberg

Barregård

2006

J of Applied Toxicology

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The Clara cell protein CC16, secreted from Clara cells in the lung, is discussed as a potential biomarker for toxic effects on the airways. An increased concentration of CC16 in serum may be caused by increased permeability of the lungs, caused by high levels of air pollution. Since CC16 is eliminated by renal excretion, it may be possible to use urine instead of serum samples. Few studies have been conducted on urinary CC16 (U-CC16), however. The aim was to investigate the optimal way of sampling and quantifying CC16 in urine samples and compare CC16 in human serum and urinary samples. Repeated sampling was performed in two groups of healthy subjects. First morning urine, 24 h urine, and matched blood and urine samples were collected. The excretion of U-CC16 increased over the day, e.g. from 0.08 microg h(-1) in the morning to 0.28 microg h(-1) in daytime and 0.16 microg h(-1) in the evening (medians in males). Morning samples (microg h(-1)) from males properly reflected the 24 h excretion (r = 0.91). The best correlation with 24 h excretion was obtained with creatinine-corrected first morning urine samples (r > 0.9). Generally, females had lower excretion of CC16 than males (medians 2.5 microg 24 h(-1) in females and 16 microg 24 h(-1) in males). There was significant intraindividual variation, but the interindividual variation was larger in both groups. There was an association between serum CC16 (S-CC16) and U-CC16 in morning samples. With optimal methods for sampling U-CC16, urine samples may be used in experimental studies of air pollution.

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Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 85%

Methodological aspects on measurement of Clara cell protein in urine as a biomarker for airway toxicity, compared with serum levels

Andersson

Lundberg

Barregård

2006

J of Applied Toxicology

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“…Serum CC16 rises as the glomerular filtration rate declines. [15][16][17] In the experimental animal model that used IPO, MMT or ANTU to damage Clara cells or endothelial cells, it was shown that the serum CC16 concentration was increased in all treated groups with a pattern of changes quite opposed to that in BALF. 14 As this elevation could not be due to an increase in synthesis or release of the protein in the respiratory tract, it could be explained by the reduction of renal clearance.…”

Section: Discussionmentioning

confidence: 99%

Pneumoproteins as markers of paraquat lung injury: A clinical case

Hantson

Weynand

Doyle

et al. 2008

Journal of Forensic and Legal Medicine

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“…One of mechanisms could represent interindividual differences in the lung-blood passage or in the synthesis/secretion of the protein in the respiratory tract, as suggested by the great dispersion of the levels in BALF [12,46,48]. Furthermore, standardization of assays will be required at least by defining reference material with defined assigned value [12,[46][47][48][49]. Different extrapulmonary factors have been shown to influence the concentration.…”

Section: Distribution Of Cc10/ug/p1 In Body Fluidsmentioning

confidence: 99%

Clinical Aspects of Clara Cell 10-kDa Protein / Uteroglobin (Secretoglobin 1A1)

Shijubo

Kawabata²,

Sato³

et al. 2003

CPD

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Clara cell 10-kDa protein (CC10)/ uteroglobin (UG) is a nonglycoprotein with a molecular mass of 16 kilodaltons, which is produced by mucosal epithelial cells in the lung (Clara cells), uterus and prostate. Like other low molecular weigh proteins it is catabolized in renal proximal tubules. Structurally it is a homodimer of subunits of 70 amino acids covalently bound in an antiparallel manner. It belongs to secretogobin (SCGB) family and is assigned as subgroup 1A1. The function of the protein so far elucidated is immunoregulatory and anti-inflammatory in innate immunity. The knockout mouse of UG gene resulted in aggravation of inflammation by allergic and hyperoxic stimuli. It also showed very similar pathological features with human IgA nephropathy. The value is changed in the lung fluid and serum of various inflammatory and allergic lung diseases. Several kinds of single nucleotide polymorphisms (SNPs) in human CC10/UG gene were recently discovered; Adenine allele accumulation in G38A SNP has possible association with asthma and IgA nephropathy, being paralleled with disease severity of IgA nephropathy. Its expression is enhanced by some transcriptional factors induced by cytokines such as interferon-gamma. For cancer cells, the protein functions as an antagonist of neoplastic phenotype. CC10/UG forms one of intra- and intercellular regulators involved in inflammation and malignant transformation in the respiratory and urogenital fields.

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The Renal Handling of Protein 1 (Clara Cell Protein): Effect of Age, Sex and Renal Dysfunction

Cited by 21 publications

References 0 publications

Methodological aspects on measurement of Clara cell protein in urine as a biomarker for airway toxicity, compared with serum levels

Methodological aspects on measurement of Clara cell protein in urine as a biomarker for airway toxicity, compared with serum levels

Pneumoproteins as markers of paraquat lung injury: A clinical case

Clinical Aspects of Clara Cell 10-kDa Protein / Uteroglobin (Secretoglobin 1A1)

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