The Renal Mechanism of the Formation and Inactivation of Erythropoietin

Kuratowska, Z

doi:10.1111/j.1749-6632.1968.tb15145.x

Cited by 29 publications

(13 citation statements)

References 10 publications

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“…Per-fusates of kidneys of anoxic rats also enhance erythropoietic activity when incubated with normal serum (4). Association of the erythropoietic factor with the nuclei of kidney cells has been recently reported (5).…”

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confidence: 98%

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Erythropoietin: Production by a Particulate Fraction of Rat Kidney

Contrera¹,

Gordon²

1966

Science

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An erythropoietic factor was extracted with hypotonic phosphate buffer from the kidneys of hypoxic rats. Normal rat serum enhanced the activity of this factor, which is associated with the light mitochondrial fraction. The data suggest that the renal factor is not physiologically active unless it interacts with a serum carrier or activator, or that the factor may be an enzyme which produces erythropoietin from some serum substrate.

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confidence: 98%

“…Association of the erythropoietic factor with the nuclei of kidney cells has been recently reported (5).…”

mentioning

confidence: 98%

Erythropoietin: Production by a Particulate Fraction of Rat Kidney

Contrera¹,

Gordon²

1966

Science

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“…A renal erythropoietic factor (erythrogenin) has been found in the nuclear (13) and light mitochondria1 (14) fractions of the kidney and is capable of generating erythropoietic activity when reacted with a plasma substrate. Therefore, it is possible that the epithelial cell may be a site in the kidney where erythrogenin acts on a substrate to generate ery thropoietin.…”

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confidence: 99%

The Cytological Localization of Erythropoietin in the Human Kidney Using the Fluorescent Antibody Technique

Busuttil

Roh

Fisher

1971

Experimental Biology and Medicine

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“…Inhibition has been clearly demonstrated with tissue homogenates (4)(5)(6). In these investigations much emphasis has been placed on the kidney in view of its important role in the production or release of erythropoietin; however, liver and spleen homogenates also inhibit erythropoietin but bone marrow apparently does not (6).…”

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confidence: 97%