The Renal Protective Effect of Jiangya Tongluo Formula, through Regulation of Adrenomedullin and Angiotensin II, in Rats with Hypertensive Nephrosclerosis

Lin, Han Chieh; Ma, Yan; Qin, Jian; Li, Lina; Gao, Yue; Zhang, Xiaoyu; Guo, Yi; Song, Lin-mei; Luo, Yanni; Chi, Xiaoyi

doi:10.1155/2015/428106

Cited by 4 publications

(3 citation statements)

References 27 publications

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“…It was shown that YGY reduced excessive PSV in the interlobular arteries of rats with chronic renal failure, while increasing EDV through vasodilation and attenuating the effect of excessive ow resistance on the vascular endothelium. Notably, the PSV of EPO −/− mice was different from that of adenine-induced chronic renal failure rats, which may be due to a certain degree of hypertensive manifestation induced by adenine [45], but the blood pressure of adenine-induced chronic renal failure rats was not measured in this experiment, which is one of the shortcomings of this study.…”

Section: Ygy Improved Microcirculatory Disturbances In Adenine-induce...mentioning

confidence: 76%

The aqueous extract of You-Gui-Yin improves renal microcirculatory disturbances in chronic renal failure rats by activating the EPO/PI3K/AKT/VEGF pathway

Chen

Yuan

et al. 2022

Preprint

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Background You-Gui-Yin (YGY) is a traditional Chinese recipe used for treating renal function diseases which is recorded in Jingyue Quanshu written by Zhang Jingyue in Ming dynasty. According to traditional Chinese medicine theory,Insufficient kidney yang leads to blood blockage and tends to create localised blood microcirculation disorders. However, the mechanism by which Right Return Drink improves microcirculatory disorders has not been discovered. Methods The potential therapeutic effects of YGY extract on chronic renal failure were investigated in vivo using adenine-induced chronic renal failure rats. Firstly, we observed the therapeutic effects of YGY extract on renal impairment, histopathological patterns and serum biochemical parameters in adenine-induced chronic renal failure rats. Secondly, in pre-laboratory data, YGY was found to promote EPO production in rats and mice. Modern pharmacological studies have found that EPO has a role in angiogenesis, and that normal microvascular function and morphology are directly related to the performance of the renal microcirculation. Subsequently, to assess the effect of EPO on renal microcirculation, we monitored changes in renal microcirculation using EPO cKO mice, using photoacoustic imaging (PAI). Finally, the expression of renal EPO, EPOR, PI3K, p-PI3K (p110), AKT, p-AKT (Ser473), and VEGF proteins was examined by Western blot and other techniques to investigate the possible mechanisms of EPO-induced renal microcirculatory disorders and the possible intrinsic mechanisms of YGY extracts to improve microcirculation, and whether they are related to the promotion of angiogenesis and improving vascular function. Results EPO−/− mice produce significant pathological damage to the mouse kidney due to low levels of EPO protein, and the damage to their renal microcirculation is manifested by abnormal renal hemodynamics, and significant abnormalities in renal blood supply and oxygen saturation. YGY extract ameliorated the microcirculatory impairment in rats with chronic renal failure. In detail, YGY extract improved renal function by restoring the damaged renal capillary network, increasing renal blood flow, and expanding renal blood distribution to maintain vascular function. In addition, the expression of PI3K/AKT/VEGF pathway was significantly reduced in the kidney of EPO−/− mice, indicating that this pathway may be a relevant pathway for renal microcirculatory disorders caused by the lack of EPO. And the potential mechanism of YGY to improve microcirculatory disorders may be related to the activation of EPO/PI3K/AKT/VEGF pathway. Conclusions YGY extract was shown to prevent the deterioration of renal function and renal microcirculation in rats with adenine-induced chronic renal failure, possibly by a mechanism related to the activation of the EPO/VEGF signalling pathway.

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Section: Ygy Improved Microcirculatory Disturbances In Adenine-induce...mentioning

confidence: 76%

The aqueous extract of You-Gui-Yin improves renal microcirculatory disturbances in chronic renal failure rats by activating the EPO/PI3K/AKT/VEGF pathway

Chen

Yuan

et al. 2022

Preprint

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“…The mechanism includes alleviation of SHR and inhibition of 293T cells' effort induced by AngII through the epigenetic pathway associated with nicotinamide N-methyltransferase expression ( 47 ). The Jiangya Tongluo formula can regulate the protective effect of adrenomedullin and angiotensin in rats with hypertensive nephrosis ( 48 ). The heart-protecting musk pill can decrease the partial levels of AngII in SHR kidney, thus treating hypertensive nephropathy ( 49 ).…”

Section: Mechanism Of Herbal Medicine In the Treatment Of Hypertensivmentioning

confidence: 99%

Mechanism of herbal medicine on hypertensive nephropathy (Review)

Dong

Dai

Feng³

et al. 2021

Mol Med Rep

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Hypertensive nephropathy is the most common complication of hypertension, and is one of the main causes of end-stage renal disease (ESRD) in numerous countries. The basic pathological feature of hypertensive nephropathy is arteriolosclerosis followed by renal parenchymal damage. The etiology of this disease is complex, and its pathogenesis is mainly associated with renal hemodynamic changes and vascular remodeling. Despite the increased knowledge on the pathogenesis of hypertensive nephropathy, the current clinical treatment methods are still not effective in preventing the development of the disease to ESRD. Herbal medicine, which is used to relieve symptoms, can improve hypertensive nephropathy through multiple targets. Since there are few clinical studies on the treatment of hypertensive nephropathy with herbal medicine, this article aims to review the progress on the basic research on the treatment of hypertensive nephropathy with herbal medicine, including regulation of the renin angiotensin system, inhibition of sympathetic excitation, antioxidant stress and anti-inflammatory protection of endothelial cells, and improvement of obesity-associated factors. Herbal medicine with different components plays a synergistic and multi-target role in the treatment of hypertensive nephropathy. The description of the mechanism of herbal medicine in the treatment of hypertensive nephropathy will contribute towards the progress of modern medicine.

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“…Traditional Chinese medicine (TCM) and traditional herbs are beneficial for hypertensive renal damage in both symptoms and causes. TCM can lower the blood pressure and protect the kidney as an efficient and practical means of prevention [ 3 – 5 ]. The Yishen Pinggan Recipe (YPR) is a compound prepared from tradition Chinese herbs used for treating hypertension.…”

Section: Introductionmentioning

confidence: 99%

Effects of Yishen Pinggan Recipe on Renal Protection and NF‐κB Signaling Pathway in Spontaneously Hypertensive Rats

Luo

Zhu

Gao

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Inflammation is an important etiological factor of hypertensive renal damage. The effects of Yishen Pinggan Recipe (YPR) on urine microalbumin, histology, and NF-κB/P65, IκB-α, IL-1β, IL-6, and TNF-α in renal tissues were evaluated in SHR to explore the mechanism of its renal protection in hypertensive renal damage. The SBP of 12-week-old SHR was 192.41 ± 3.93 mmHg and DBP was 142.38 ± 5.79 mmHg. Without treatment, the 24-week-old SHRs' SBP was 196.96 ± 3.77 mmHg and DBP was 146.08 ± 4.82 mmHg. After the 12-week-old SHR were administered YPR for 12 weeks, the rats' SBP was 161.45 ± 7.57 mmHg and DBP was 117.21 ± 5.17 mmHg; YPR could lower blood pressure in SHR. And renal function damage was observed in 24-week-old SHR without treatment, manifested as urine protein and morphological changes which could be inhibited by YPR. In addition, YPR could reduce the expression of inflammatory cytokines (IL-1β, IL-6, and TNF-α) in kidneys. It could also inhibit the nuclear translocation of NF-κB p65 and degradation of IκB-α in renal cells, indicating that the NF-κB signaling pathway was inhibited by YPR. Finally, the study suggests that YPR could significantly improve the renal function in SHR. The mechanism could be attributed to its inhibition of renal NF-κB signaling pathway and inflammation.

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The Renal Protective Effect of Jiangya Tongluo Formula, through Regulation of Adrenomedullin and Angiotensin II, in Rats with Hypertensive Nephrosclerosis

Cited by 4 publications

References 27 publications

The aqueous extract of You-Gui-Yin improves renal microcirculatory disturbances in chronic renal failure rats by activating the EPO/PI3K/AKT/VEGF pathway

The aqueous extract of You-Gui-Yin improves renal microcirculatory disturbances in chronic renal failure rats by activating the EPO/PI3K/AKT/VEGF pathway

Mechanism of herbal medicine on hypertensive nephropathy (Review)

Effects of Yishen Pinggan Recipe on Renal Protection and NF‐κB Signaling Pathway in Spontaneously Hypertensive Rats

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