The repair of osteochondral defects in osteoarthritic rabbit knees by the use of carbon fibre

Minns, R.J.; Muckle, D. S.; Donkin, J. E.

doi:10.1016/0142-9612(82)90038-2

Cited by 49 publications

(17 citation statements)

References 13 publications

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“…13 Synthetic biodegradable materials used include polyesters, such as polyglycolic acid (PGA), poly-L-lactic acid (PLLA), and PGA-PLLA copolymer. 14 The synthetic nonbiodegradable materials include carbon fiber mesh 15 and hydroxyapatite/Dacron composites. 16 Many studies using chondrocytes and/or cells with chondrogenic potential have shown that these different biomaterials can support formation of collagen and proteoglycan (PG) -containing tissue.…”

Section: Introductionmentioning

confidence: 99%

GAG‐augmented polysaccharide hydrogel: A novel biocompatible and biodegradable material to support chondrogenesis

Sechriest

Miao

Niyibizi

et al. 1999

J. Biomed. Mater. Res.

281

189

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The quality of articular cartilage engineered using a cell-polymer construct depends, in part, on the chemical composition of the biomaterial and whether that biomaterial can support the chondrocytic phenotype. Acknowledging the supportive influence of tissue-specific matrix molecules on the chondrocytic phenotype, we have combined chondroitin sulfate-A (CSA) and chitosan, a glycosaminoglycan (GAG) analog, to develop a novel biomaterial to support chondrogenesis. Chitosan is a polycationic repeating monosaccharide of beta-1,4-linked glucosamine monomers with randomly located N-acetyl glucosamine units. Chitosan may be combined with the polyanionic CSA such that ionic crosslinking results in hydrogel formation. Bovine primary articular chondrocytes, when seeded onto a thin layer of CSA-chitosan, form discrete, focal adhesions to the material and maintain many characteristics of the differentiated chondrocytic phenotype, including round morphology, limited mitosis, collagen type II, and proteoglycan production. Our findings suggest CSA-chitosan may be well suited as a carrier material for the transplant of autologous chondrocytes or as a scaffold for the tissue engineering of cartilage-like tissue.

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Section: Introductionmentioning

confidence: 99%

GAG‐augmented polysaccharide hydrogel: A novel biocompatible and biodegradable material to support chondrogenesis

Sechriest

Miao

Niyibizi

et al. 1999

J. Biomed. Mater. Res.

281

189

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“…In vivo this polymer should absorb tissue fluids in situ and hence gain similar biological properties to those of the host tissue and cells; this may create an environment which encourages cartilage overgrowth. The high water content of this polymer is similar to that of hyaline cartilage [1][2][3][4][5][6][7][8][9][10][11][12][13]14], the natural tissue which must be encouraged to repair. The characterization of early tissue components growing over the novel polymer allows an evaluation of the biocompatibility of this polymer system and its potential for use in articular cartilage resurfacing.…”

mentioning

confidence: 93%

“…Investigators have filled the cartilage defect with a variety of natural and synthetic scaffolding materials, ranging from reconstructed collagen sponges [8] to carbon fibre implants [9] and polylactic acid (PLA) and periosteal grafts [10,11], all intended to encourage the resurfacing of the defective region with a cartilagenous matrix.…”

Section: Introductionmentioning

confidence: 99%

The regeneration of articular cartilage using a new polymer system

Downes

Archer

Kayser

et al. 1994

J Mater Sci: Mater Med

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A polymer system based on room temperature polymerising poly(ethylmethacrylate) polymer powder and tetrahydrofurfuryl monomer has been investigated as a biomaterial for encouraging articular cartilage repair. This heterocyclic methacrylate polymer system swells slightly in situ and thus provides a good interface with subchondral bone resulting in mechanical stability with favourable uptake kinetics. Another feature of this polymer system is that it exhibits high water uptake which leads to absorption of the surrounding tissue fluid and matrix proteins, including growth factors; this may encourage the formation of new cartilage. Three weeks after implantation the tissue overgrowth contained cartilage components: chondrocytes, collagen type II, chondroitin 4-sulphate and chondroitin 6-sulphate. In addition numerous chondrocyte clones were observed at the edge of the defect and in the newly repaired tissue. By six weeks a superficial articulating surface was continuous with the normal articular cartilage with underlying tissue which showed some evidence of endochondral ossification. By nine weeks the surface covering of new cartilage had a widened and an irregular zone of calcified cartilage with thickened subchondral bone was present. At eight months the resurfaced cartilage remained intact above a remodelled subchondral bone end plate.

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“…1 Carbon fiber arthroplasty appears to be appropriate in the surgical management of ICRS Grades 3 and 4 articular cartilage lesions in the painful knee. 2,3,4,5 • Carbon fiber rods (Medicarb, Surgicraft, England or Chopin pins, BMI Biomedical Implants GmbH, Hanstedt, N. Germany). The carbon fibers are fabricated from organic fibers such as polyacrylonitrile or rayon.…”

Section: Introductionmentioning

confidence: 99%

Bone Marrow Stimulating Techniques

Brittberg¹

2011

Cartilage Surgery

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The repair of osteochondral defects in osteoarthritic rabbit knees by the use of carbon fibre

Cited by 49 publications

References 13 publications

GAG‐augmented polysaccharide hydrogel: A novel biocompatible and biodegradable material to support chondrogenesis

GAG‐augmented polysaccharide hydrogel: A novel biocompatible and biodegradable material to support chondrogenesis

The regeneration of articular cartilage using a new polymer system

Bone Marrow Stimulating Techniques

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