The replication of bacteriophage ∅X174 in a mutant of Escherichia coli strain C

Cis -Limited Action of the Gene-A Product of Bacteriophage ϕX174 and the Essential Bacterial Site

“…Thus, the initiation of all events leading to the production of progeny RF-and single-stranded DNA depends on this gene. In addition to the viral function, a number of host-cell functions are required to replicate RF (3,4). Although the nature of the impaired functions in replication-deficient host cells is poorly understood, one of these mutants, rep3-, (5) has proven useful in elucidation of the function of the viral gene A.…”