The reproducibility of coronary artery calcium scoring on different software platforms

Ajlan, Muhammad; Ahmed, Amjad; Alskaini, Abdullah M.; Abukhaled, Norah F.; Alsaileek, Ahmed; Ajlan, Amr M.; Sulaiman, Ihab; Al-Mallah, Mouaz

doi:10.1016/j.ijcard.2015.03.133

Cited by 6 publications

(2 citation statements)

References 9 publications

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“…Additionally, the observed transferability was also proven for Syngo.Via, which was not included in the study by Eberhard et al Taken together, both studies demonstrate the feasibility of MDCT for the calcium quantification of the aortic valve, with likely significant clinical implications. These results coincide with data from non-contrast-enhanced coronary artery MDCTs, according to which the likelihood of coronary artery disease was estimated by determining the calcium load, which underscores the importance of calcium quantification as a pathological substrate [30,31].…”

Section: Discussionsupporting

confidence: 81%

Head-to-Head Comparison of Different Software Solutions for AVC Quantification Using Contrast-Enhanced MDCT

Evertz

Hub

Backhaus

et al. 2021

JCM

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Aortic valve calcification (AVC) in aortic stenosis patients has diagnostic and prognostic implications. Little is known about the interchangeability of AVC obtained from different multidetector computed tomography (MDCT) software solutions. Contrast-enhanced MDCT data sets of 50 randomly selected aortic stenosis patients were analysed using three different software vendors (3Mensio, CVI42, Syngo.Via). A subset of 10 patients were analysed twice for the estimation of intra-observer variability. Intra- and inter-observer variability were determined using the ICC reliability method, Bland-Altman analysis and coefficients of variation. No differences were revealed between the software solutions in the AVC calculations (3Mensio 941 ± 623, Syngo.Via 948 mm3 ± 655, CVI42 941 ± 637; p = 0.455). The best inter-vendor agreement was found between the CVI42 and the Syngo.Via (ICC 0.997 (CI 0.995–0.998)), followed by the 3Mensio and the CVI42 (ICC 0.996 (CI 0.922–0.998)), and the 3Mensio and the Syngo.Via (ICC 0.992 (CI 0.986–0.995)). There was excellent intra- (3Mensio: ICC 0.999 (0.995–1.000); CVI42: ICC 1.000 (0.999–1.000); Syngo.Via: ICC 0.998 (0.993–1.000)) and inter-observer variability (3Mensio: ICC 1.000 (0.999–1.000); CVI42: ICC 1.000 (1.000–1.000); Syngo.Via: ICC 0.996 (0.985–0.999)) for all software types. Contrast-enhanced MDCT-derived AVC scores are interchangeable between and reproducible within different commercially available software solutions. This is important since sufficient reproducibility, interchangeability and valid results represent prerequisites for accurate TAVR planning and its widespread clinical use.

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Section: Discussionsupporting

confidence: 81%

Head-to-Head Comparison of Different Software Solutions for AVC Quantification Using Contrast-Enhanced MDCT

Evertz

Hub

Backhaus

et al. 2021

JCM

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“…Siemens Syngo.via software overestimated phantom calcifications compared with GE SmartScore software and the ground truth in a previous study [22]. Moreover, different software programs were compared by Ajlan et al (4DM Calcium score (INVIA, Ann Arbor, MI, USA), and Smart score (General Electric, Milwaukee, WI)) and Weininger et al (Syngo Calcium Scoring (Siemens Healthcare, Erlangen, Germany), Aquarius (TeraRecon, San Mateo, CA, USA), and Vitrea (Vital Images, Minnetonka, MN, USA)), who found a high correlation between software outcomes [26,27].…”

Section: Discussionmentioning

confidence: 99%

Validation of a Length-Adjusted Abdominal Arterial Calcium Score Method for Contrast-Enhanced CT Scans

Devia-Rodriguez,

Derksen,

de Groot

et al. 2023

Diagnostics

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Background: The Agatston score on noncontrast computed tomography (CT) scans is the gold standard for calcium load determination. However, contrast-enhanced CT is commonly used for patients with atherosclerotic cardiovascular diseases (ASCVDs), such as peripheral arterial occlusive disease (PAOD) and abdominal aortic aneurysm (AAA). Currently, there is no validated method to determine calcium load in the aorta and peripheral arteries with a contrast-enhanced CT. This study validated a length-adjusted calcium score (LACS) method for contrast-enhanced CT scans. Method: The LACS (calcium volume in mm3/arterial length in cm) in the abdominal aorta was calculated using four-phase liver CT scans of 30 patients treated between 2017 and 2021 at the University Medical Center Groningen (UMCG) with no aortic disease. Noncontrast CT scans were segmented with a 130 Hounsfield units (HU) threshold, and a patient-specific threshold was used for contrast-enhanced CTs. The LACS was calculated and compared from both segmentations. Secondly, the interobserver variability and the influence of slice thickness (0.75 mm vs. 2.0 mm) was determined. Results: There was a high correlation between the LACS from contrast-enhanced CT scans and the LACS of noncontrast CTs (R2 = 0.98). A correction factor of 1.9 was established to convert the LACS derived from contrast-enhanced CT to noncontrast CT scans. LACS interobserver agreement on contrast-enhanced CT was excellent (1.0, 95% confidence interval = 1.0–1.0). The 0.75 mm CT threshold was 541 (459–625) HU compared with 500 (419–568) HU on 2 mm CTs (p = 0.15). LACS calculated with both thresholds was not significantly different (p = 0.63). Conclusion: The LACS seems to be a robust method for scoring calcium load on contrast-enhanced CT scans in arterial segments with various lengths.

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Reproducibility of aortic valve calcification scoring with computed tomography – An interplatform analysis

Eberhard

Hinzpeter

Polacin

et al. 2019

Journal of Cardiovascular Computed Tomography

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The reproducibility of coronary artery calcium scoring on different software platforms

Cited by 6 publications

References 9 publications

Head-to-Head Comparison of Different Software Solutions for AVC Quantification Using Contrast-Enhanced MDCT

Head-to-Head Comparison of Different Software Solutions for AVC Quantification Using Contrast-Enhanced MDCT

Validation of a Length-Adjusted Abdominal Arterial Calcium Score Method for Contrast-Enhanced CT Scans

Reproducibility of aortic valve calcification scoring with computed tomography – An interplatform analysis

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