In the construction process of Sunan 23-113H2 well, there wasYanchang well, Liujiagou well and Shihezi well, when passing through the well, the mudstone collapse of the large slope section caused the difficulty of reaming off, after repeated reaming off, the wellbore still cannot be unblocked. Finally, the well structure was changed from the conventional Third Interval to the optimized Third Interval, and the technical casing is lowered to the depth of the inclined 45° well in the inclined shaft section. After the Third Interval, the mudstone of the large inclined section and the horizontal section collapsed, and the well leakage of the inclined well section and the horizontal section was still prominent. According to the construction situation of the Third Interval of the well, this paper optimizes the drilling fluid and refines the leak prevention and plugging measures through indoor experiments to provide technical support for safe drilling.