The residue levels of narasin in eggs of laying hens fed with unmedicated and medicated feed

Rokka, Mervi; Eerola, Susanna; Perttilä, Ulla; Rossow, Laila; Venäläinen, Eija; Valkonen, Eija; Valaja, Jarmo; Peltonen, Kimmo

doi:10.1002/mnfr.200400042

Cited by 36 publications

(36 citation statements)

References 13 publications

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“…This has also been demonstrated by other researchers (Rokka et al 2005;EFSA 2007). Feed containing 0.1-5 mg kg À1 lasalocid resulted in whole egg concentrations of 6-8 and 300 mg kg À1 lasalocid, respectively (EFSA 2007).…”

Section: Discussionsupporting

confidence: 78%

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Transfer of the coccidiostats monensin and lasalocid from feed at cross-contamination levels to whole egg, egg white and egg yolk

Vandenberge¹,

Delezie²,

Huyghebaert³

et al. 2012

Food Additives & Contaminants: Part A

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Recent legislation has addressed the unavoidable carry-over of coccidiostats and histomonostats in feed, which may lead to the presence of residues of these compounds in eggs. In this study, laying hens received cross-contaminated feed at a ratio of 2.5%, 5% and 10% of the therapeutic dose of monensin and lasalocid for broilers. The eggs were collected during the treatment and depletion period and were analysed using liquid chromatography-tandem mass spectrometry. The different egg matrices were separated and analysed during the plateau phase. High lasalocid concentrations, which exceeded the maximum residue level, and low monensin concentrations were found in whole egg. Plateau levels were reached at days 7-9 for lasalocid and at days 3-5 for monensin. For lasalocid, the highest concentrations were measured in egg yolk; residue concentrations in egg white were very low.

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Section: Discussionsupporting

confidence: 78%

“…Rokka et al (2005) found, however, that egg production was not (monensin) or significantly (lasalocid) decreased if laying hens received feed containing monensin at 100 mg kg À1 or lasalocid at 115-150 mg kg À1 , respectively. Orally administered substances need to pass the intestinal wall.…”

Section: Discussionmentioning

confidence: 73%

Transfer of the coccidiostats monensin and lasalocid from feed at cross-contamination levels to whole egg, egg white and egg yolk

Vandenberge¹,

Delezie²,

Huyghebaert³

et al. 2012

Food Additives & Contaminants: Part A

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show abstract

“…Cross-contamination of feed is a well-known problem and may be due to improperly constructed equipment, poor dust control or inadequate clean-out procedures between sequential batches of feed (FDA 2005). Even very low levels of antibiotic contamination may result in significant residues in food, as confirmed by studies on coccidiostats in poultry feed (Kennedy et al 1998;Rokka et al 2005) and sulfadimidine in swine (Biehl et al 1981;McCaughey et al 1990). Sulfonamides are veterinary drugs routinely used in farm animals and sulfonamide residues in animal products, such as eggs and milk, have recently been investigated (Furusawa and Kishida 2002;Cavaliere et al 2003;Juhel-Gaugain et al 2005).…”

Section: Introductionmentioning

confidence: 79%

A sulfadimidine model to evaluate pharmacokinetics and residues at various concentrations in laying hen

Tansakul

Niedorf

Kietzmann

2007

Food Additives and Contaminants

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Low level intake of drugs from the ingestion of contaminated feed may lead to residue problems in food animals. Sulfadimidine (SDD) was used as a model to determine the residue risk at various doses in laying hens. The drug was administered as a single intravenous injection (100 mg kg(-1) body weight, BW), as a single oral dose (100, 30, 10, 3, 1 mg kg(-1) BW) and via medicated feed for 7 consecutive days (30, 10, 3 mg kg(-1) BW). Drug levels were determined with HPLC-UV for plasma, yolk and albumen. Pharmacokinetic values, which were calculated using a first-order one-compartment model, residue levels and transfer rates into the eggs were found to be dose-dependent. Even low doses of 3 and 1 mg kg(-1) BW resulted in measurable residues in yolk and albumen 1 day after a single oral administration. After ingestion of medicated feed at 3 mg kg(-1) BW, mean drug levels at 0.14 +/- 0.01 microg g(-1) were found in albumen and at 0.09 +/- 0.01 microg ml(-1) in plasma. Generally, the residue levels in albumen and plasma were higher than in yolk. These findings demonstrate a residue risk for the consumer even after low level intake of drugs.

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“…Eimeria türleri tarafından meydana getirilen, proventrikülden başlayarak kolona kadar olan emilim yollarının harabiyeti ve şiddetli ishalle karakterize olan bu hastalığın tedavi edilmediği takdirde ölümle sonuçlanması kaçınılmazdır. Tedavisinde değişik antibiyotiklerin yanı sıra genelde antikoksidiyal olarak karboksilik iyonoforlar kullanılmaktadır (Parelman, 1993;Rokka, 2005).…”

Section: Introductionunclassified

Effect of the Lasalosit used in Broilers and Different Heat Treatment Process on its Residual Levels

Bilici¹

2015

J Food Health Sci

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Öz:Kanatlı Koksidiyozisi eimeria türlerinin neden olduğu önemli bir protozon hastalığıdır. Kanatlı endüstrisinde önemli ekonomik kayıplara yol açmaktadır. Koksidiyozisin kontrölünde nikarbazin, halofuginon, robenidin, diklazuril, monensin, salinomisin, narasin, lasalosit ve maduramisin gibi ilaçlar kullanılmaktadır. Kullanı-lan ilaçların kalıntıları izlenmesi ve gerekli önlemlerin alınması insan sağlığı açısından büyük bir önem taşı-maktadır. Bu çalışmada İstanbul'da tüketime sunulan tavuk eti ve yumurtalardan aldığımız 150'şer adet numune de lasalosit kalıntı ve düzey izlemesi yapılmıştır. Genel olarak broilerlerdeki (tavuk) yedirme koşulla-rında lasalosit 75-125 µg/g ile sınırlandırılmıştır. Bu şartlarda yapılan yedirme denemeleri sonrasında 1. 3. ve 5. ve 7. günlerde alınan dokularda analizler yapılmış, 1. 3. 5. gün dokularındaki lasalosit kalıntı düzeyi önemli bulunmuştur. Kalıntı miktarı yüksek olan 1. 3. ve 5. gün dokuları kızartma, haşlama, +4°C muhafaza ve dondurmaya işleme ve depolama proseslerine tabi tutulmuştur. Sonuç olarak lasalosit giderek hızla azalan bir rezidüye sahip olduğu ve dokudaki kalıntılarının ısıl işlemlerden etkilendikleri tespit edilmiştir. Anahtar Kelimeler:Lasalosit, İyonofor antikoksidiyal ilaç, Kalıntı düzeyi, Isıl işlem Abstract: Effect of the Lasalosit used in Broilers and Different Heat Treatment Process on its Residual LevelsAvian coccidiosis is an important disease caused by protozoa of the genus Eimeria. İt leads to significant economic losses in the poultry industry. For control of coccidiosis in avian, using pharmacological active substance such as nikarbazin, halofuginon, robenidin, diclazuril, monensin, salinomycin, naracin, lasalocit and maduramicin. Residues of used drugs are significant for human healthy. In this study, we have taken from the poultry meat and eggs available for consumption in Istanbul with 150 specimens were screened for lasalosit. In general, the optimal feeding conditions has been limited 75-125 µg/g for lasalosit. After the feeding under these circumstances 1st, 3rd, 5th, and 7th day the tissues was analyzed. 1st, 3rd, 5th days detected tissue residues were considered important. High residue including which 1st, 3rd and 5th day tissues treated fried, boiled, held on +4°C and freezed. Consequently it was confirmed that lasolocid residue have decreasing and affected by heat treatment of residues in tissues.

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The residue levels of narasin in eggs of laying hens fed with unmedicated and medicated feed

Cited by 36 publications

References 13 publications

Transfer of the coccidiostats monensin and lasalocid from feed at cross-contamination levels to whole egg, egg white and egg yolk

Transfer of the coccidiostats monensin and lasalocid from feed at cross-contamination levels to whole egg, egg white and egg yolk

A sulfadimidine model to evaluate pharmacokinetics and residues at various concentrations in laying hen

Effect of the Lasalosit used in Broilers and Different Heat Treatment Process on its Residual Levels

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