The response of rat adrenal medulla to oxytocin

Plećaš, B.; Ugresic, N.; Hristić, M; Popović, Aleksandar D.; Jovović, Djurdjica

doi:10.3109/13813458909075070

Cited by 8 publications

(4 citation statements)

References 15 publications

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“…The finding that OT stimulates the mitotic activity of adrenomedullary chromaffin cells of intact male rats fits well with our previously reported data on its effect on the number of chromaffin cells (Plecas et al 1989). In the present study the effect of OT is evident on the 3rd day of the treatment.…”

Section: Discussionsupporting

confidence: 93%

“…The influence of this neuropeptide on catecholamine secretion has already been shown (Gibbs 1986;Nussey et al 1987). In a previous study {Plecas, Ugresic, Hristic, Popovic and Jovovic 1989) we revealed, by means of stereology, that in male rats OT enhanced the total number of adrenomedullary chromaffin cells, which indicated a mitotic action. No data on the mitogenic effect of OT on the chromaffin tissue are available, and because of that we examined the mitogenic potency of OT using a metaphase arrest technique.…”

Section: Introductionmentioning

confidence: 58%

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Mitotic Stimulation of Adrenal Medullary Chromaffin Cells by Oxytocin

Plećaš¹,

Hristić²,

Popović³

et al. 1990

Horm Metab Res

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 58%

Mitotic Stimulation of Adrenal Medullary Chromaffin Cells by Oxytocin

Plećaš¹,

Hristić²,

Popović³

et al. 1990

Horm Metab Res

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“…Otr delineates a subset of nNos+ SPNs projecting to the AM Next, we sought SPNs targeting the AM. Based upon literature suggesting an association between the neural hormone oxytocin (OT) and AM functions [28][29][30] , along with the documented expression of Otr mRNA in the IML of the SC 31 , we identified Otr+ SPNs as specific projectors to the AM. First, utilizing the RNAscope single-molecule in situ hybridization method, we found that the majority of Otr+ cells were nNos+ in the IML of the thoracic SC (Extended Data Fig.…”

Section: Cartpt+ Spns Selectively Project To the Cg/smgmentioning

confidence: 99%

Parallel Labeled-Line Organization of Sympathetic Outflow for Selective Organ Regulation in Mice

Harima,

Tsurutani,

Uchida

et al. 2024

Preprint

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The sympathetic nervous system is vital in maintaining homeostasis and responding to environmental changes1–3. This regulation is coordinated by the spinal sympathetic preganglionic neurons (SPNs), which influence various organs both through neuronal pathways via postganglionic neurons and through endocrine processes by innervating the adrenal gland. Despite decades of research supporting the concept of selective control within this system1,4–9, the neural circuit organization responsible for the specificity of sympathetic outflow remains poorly understood. Notably, classical anatomical studies in rats have not revealed a definitive molecular code governing SPNs, nor have they confirmed the existence of SPNs strictly corresponding to specific output targets1,6,10,11. To reconcile this discrepancy, we aim to integrate recent transcriptome data of SPNs12,13in mice with viral-genetic toolkits14to map axonal projections and manipulate the functions of SPNs governing the gastrointestinal tract and adrenal gland. Here, we have identified two subtypes of SPNs in the lower thoracic spinal cord, defined at the molecular level, exhibiting non-overlapping patterns of innervation. Chemogenetic manipulations on these distinct SPN subtypes revealed selective impacts on the digestive functions in the gastrointestinal tracts or glucose metabolism mediated by the adrenal gland, respectively. This molecularly delineated parallel labeled-line organization in sympathetic outflows presents a potential avenue for selectively manipulating organ functions.

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“…OT exerts effects also on the adrenal medulla. It was shown that chronic OT treatment leads to increased epinephrine and norepinephrine the rat adrenal medulla [62]. Moreover, it exerts bidirectional effects on the adrenal cortex where increased corticosterone levels were associated with acute OT administration.…”

Section: Effects Of Endogenous and Exogenous Ot On The Social Behaviourmentioning

confidence: 99%

Oxytocin and Stress Response

Dief¹,

Sivukhina²,

Jirikowski³

2018

OJEMD

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In response to a stressful unexpected experience, the brain activates a complex stress system that involves the organism in an adaptive response to the threatening situation. This stress system acts on several peripheral tissues and feeds back to the brain. One of its key players is oxytocin hormone. The neuropeptide, oxytocin (OT), has well-established roles during parturition and lactation. In addition to its peripheral actions, OT is released within multiple areas of the brain and influences behavioural and neuroendocrine responses to stress. Several studies suggest that oxytocin is implicated in the central control of responses to stress through modulation of corticotrophin releasing hormone (CRH). Intranasal OT application was associated with an inhibitory effect on adrenocorticotrophic hormone (ACTH) secretion and subsequent impairment of corticosterone secretion. This may be of importance for understanding and perhaps suggesting its utility to buffer stress. Synthesis and release of OT depend to a great extent on steroid hormones particularly on estradiol and corticosterone. Estrogens stimulate synthesis and release of OT and increase the number of OT receptors in some areas of the brain. However, the role of OT in mediating stress is variable and may also depend on gender and on external factors.

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The response of rat adrenal medulla to oxytocin

Cited by 8 publications

References 15 publications

Mitotic Stimulation of Adrenal Medullary Chromaffin Cells by Oxytocin

Mitotic Stimulation of Adrenal Medullary Chromaffin Cells by Oxytocin

Parallel Labeled-Line Organization of Sympathetic Outflow for Selective Organ Regulation in Mice

Oxytocin and Stress Response

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