The Response of the Macrophage to Antigenic Azoprotein, Studied in the Rabbit Ear Chamber Preparation

Abstract

Hince the well-known work of Sabin (1989) there has been increasing interest in the cytology of immunity. Using R-salt-azoprotein as the antigen, Sabin observed in fixed sections of rabbit lymph nodes and in cell suspensions appearances which she interpreted as representing the shedding of peripheral portions of the cytoplasm of the macrophages which had ingested the coloured antigen. She suggested that the shed fragments contained the antibody. Pollowing these earlier studies interest then shifted to the possible role of the lymphocyte

Aspects of the Pathogenesis of Virus Diseases

“…It has been suggested that macrophageg turn into antibody-producing cells (54), and that macrophages themselves produce antibody (92). It has also been suggested that macrophages prepare antigen for antibodyproducing cells (58,129,134), and the evidence for this has sometimes been good. In lymphoid tissue, where macrophages which have taken up virus particles are often next to the lymphoid cells which are involved in the immune response, there would be numerous opportunities for a handing over of antigen or messages about antigen.…”