The Hamiltonian structure of General Relativity (GR), for both metric and tetrad gravity in a definite continuous family of space-times, is fully exploited in order to show that: i) the Hole Argument can be bypassed by means of a specific physical individuation of point-events of the space-time manifold M 4 in terms of the autonomous degrees of freedom of the vacuum gravitational field (Dirac observables), while the Leibniz equivalence is reduced to differences in the non-inertial appearances (connected to gauge variables) of the same phenomena. ii) the chrono-geometric structure of a solution of Einstein equations for given, gauge-fixed, initial data (a 3-geometry satisfying the relevant constraints on the Cauchy surface), can be interpreted as an unfolding in mathematical global time of a sequence of achronal 3-spaces characterized by dynamically determined conventions about distant simultaneity. This result stands out as an important conceptual difference with respect to the standard chrono-geometrical view of Special Relativity (SR) and allows, in a specific sense, for an endurantist interpretations of ordinary physical objects in GR.To appear in the book Relativity and the Dimensionality of the World, A. van der Merwe ed., Springer Series Fundamental Theories of Physics.