The Results of Modern Surgical Therapy for Multiple Primary Lung Cancers

Adebonojo, Samuel A.; Moritz, Dennis; Danby, Christopher A.

doi:10.1378/chest.112.3.693

Cited by 123 publications

(82 citation statements)

References 42 publications

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“…The staging of lung cancer is crucial for the evaluation and prognosis of the disease, exchanging information among clinicians and researchers, and providing a guidance for the most appropriate treatment strategy (19)(20)(21)(22). In the present study, the 2 tumors in SMPLC patients were separately staged.…”

Section: Discussionmentioning

confidence: 99%

Early clinical diagnosis of synchronous multiple primary lung cancer

Xue

Wang

et al. 2011

Oncology Letters

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Abstract. The diagnosis of synchronous multiple primary lung cancer (SMPLC) remains a formidable challenge. The aim of the present study was to identify useful clues for the clinical diagnosis of SMPLC, in particular for the early stages. The medical records of 10 patients diagnosed with SMPLC with different histological types were analyzed retrospectively. Chest computed tomography (CT) findings showed two pulmonary lesions in all patients. The two lesions displayed malignant characteristics of primary lung cancer. The levels of a number of tumor markers, including carcinoembryonic antigen, neuron-specific enolase, cytokeratin fragment 21-1, squamous cell carcinoma and CA125 increased in 2 patients. Auxiliary examinations of other physical sites in these patients did not show signs of neoplasm metastasis. Two tumors were separately staged and appropriate treatment was carried out based on the revised stage, which provided more benefits for SMPLC patients. The diagnosis of SMPLC might be delayed or mistaken owing to its similarity to neoplasm metastasis. A high index of awareness is required for the early diagnosis of this disease. The malignant characteristics of primary lung cancer in various lesions may be valuable clues for the diagnosis of SMPLC. Alterations in the levels of tumor markers may be a poor diagnostic tool for the detection of SMPLC. Separate biopsies for different pulmonary masses should be performed for clinical staging as soon as possible and reasonable treatment based on the stage should also be selected.

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Section: Discussionmentioning

confidence: 99%

Early clinical diagnosis of synchronous multiple primary lung cancer

Xue

Wang

et al. 2011

Oncology Letters

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“…Surgery is the standard option when feasible in multiple primary cancers (1)(2)(3)(4)(5)(6)(7)(8). In our case endobronchial therapy for airway obstruction and palliative radiotherapy for tongue performed because of poor performance and advanced stage of cancers.…”

Section: Discussionmentioning

confidence: 99%

A rare synchronous tumor: primary squamous cell lung cancer and adenoid cystic carcinoma of the tongue

Karadeniz¹,

Yaşar²,

Üçsular³

et al. 2017

Tuberk Toraks

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“…Carcinoma of the lung is the leading cause of cancer death in countries whose statistical analyzes are reliable (3,5). Synchronous tumors, which are described as multiple primary tumors, are very rare (1, 2, 4, and 6).…”

Section: Discussionmentioning

confidence: 99%

“…Five year survival rate of surgical treatment is better than medical treatment (1,2). Synchronous tumors are described as two different tumors presenting at the same time in the same organ.…”

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Synchronous lung cancer cases Senkron akciğer kanseri olguları

Tokat¹

2005

Ankara Üniversitesi Tıp Fakültesi Mecmuası

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Synchronous tumor is described as two different tumors presenting at the same time in the same organ. Pulmonary tumors existing in different lobes or different sides of the lungs at the same time are defined as pulmonary synchronous tumors. We describe three different cases that were diagnosed by different methods and that had different clinical outcomes. Within the first case, the second tumor was determined while the patient was receiving chemotherapy. In the second case, the tumor was diagnosed by flow cytometric examination. And in the third case, the tumor was diagnosed intraoperatively by frozen section. Synchronous tumors are uncommon, they occur in 1-2 % of all bronchial carcinomas. Concerning the better survival rates of surgical treatment, the possibility of synchronous tumor should be remembered in the cases that have separate lesions. Key words: Lung cancer, pulmonary, synchronous tumorSenkron tümör tanımı, bir organda aynı anda iki farklı tümör saptanması olarak özetlenebilir. Akciğerlerde aynı anda farklı lokalizasyonlarda pulmoner tümör saptanması durumunda pulmoner senkron tümörden bahsedilir. Bronş karsinomu serisi içinde karşılaşılan üç pulmoner senkron tü-mör olgusunu, tanı aşamasındaki ve klinik seyirlerindeki farklılıklar nedeniyle sunulması amaçlan-dı. Birinci olgu; akciğer kanseri tanısı ile kemoterapi protokolüde iken ikinci tümör saptandı. İkinci olguda senkron tümör tanısı preoperatif "flow-sitometrik" inceleme ile ortaya konuldu. Üçüncü olguda ise senkron tümör tanısı ameliyat sırasına "frozen" biyopsi ile ispatlandı. Oldukça seyrek olarak görülen senkron tümörler tüm akciğer kanserlerinin yaklaşık % 1-2'sini oluşturmaktadır. Birden fazla kitle ile başvuran olgularda senkron tümör olasılığı akılda tutularak, olgulara cerrahi tedavi şansı verilebilmekte ve cerrahi olmayan tedavi protokollerine göre daha uzun bir sağkalım şansı sağlanabilmektedir.Anahtar kelimeler: Akciğer kanseri, pulmoner, senkron tümör L ung cancer is one of the most common causes of death associated with cancer. Five year survival rate of surgical treatment is better than medical treatment (1,2). Synchronous tumors are described as two different tumors presenting at the same time in the same organ. Pulmonary tumors existing in different lobes or different sides of the lungs at the same time are defined as pulmonary synchronous tumors (3).However surgical management of synchronous tumors is still controversial. Synchronous tumors are uncommon, occurring in 1-2 % of all lung cancers (2). In the literature 5-year survival rate of pulmonary synchronous tumors is reported between 0 % and 6 % (1, 2,4).In this study we report three different non-small cell pulmonary synchronous tumors and try to argue the role of surgical management. Case 1A 58-year-old man was admitted with dispnea. Computed tomography (CT) of the chest demonstrated a peripherally located 6x4x2 cm mass in the left lower lobe.

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The Results of Modern Surgical Therapy for Multiple Primary Lung Cancers

Cited by 123 publications

References 42 publications

Early clinical diagnosis of synchronous multiple primary lung cancer

Early clinical diagnosis of synchronous multiple primary lung cancer

A rare synchronous tumor: primary squamous cell lung cancer and adenoid cystic carcinoma of the tongue

Synchronous lung cancer cases Senkron akciğer kanseri olguları

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