“…Cancer diagnostics (imaging, biomarkers) and therapies (surgery, radiation, new medicines and devices) have led to statistically significant increases in 1-year and 5-year survival rates and improvements in cancer outcomes, with significant qualityadjusted benefit achieved at a fraction of the economic cost of increased morbidity, mortality, and loss of productive life-years [41][42][43][44][45][46]. A clear example of this progress is breast cancer, for which more effective management by innovative diagnostic and therapeutic approaches has been accompanied by approximately a fivefold increase in return on investment [42,45]. In France, it is estimated that diagnostic and therapeutic innovation has contributed to a significant decline in cancer mortality rates in the period 2002-2006 [42, 44, 46].…”