The rheological properties of beta amyloid Langmuir monolayers: Comparative studies with melittin peptide

Caruso, Benjamín; Ambroggio, Ernesto E.; Wilke, Natalia; Fidelio, Gerardo D.

doi:10.1016/j.colsurfb.2016.06.003

Cited by 17 publications

(28 citation statements)

References 43 publications

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“…Beyond these obvious properties of the sequence, the amphiphilicity of Aβ peptides has been demonstrated experimentally. Aβ(1–40), and presumably other Aβ peptides, readily form stable monolayers at the air–water interface, the most common experimental model for the oil–water interface . The amphiphilicity of Aβ is itself a cause of its self‐association.…”

Section: Effects Of Lipid Surfaces and Other Amphiphilic Or Hydrophobmentioning

confidence: 99%

“…Aβ , and presumably other Aβ peptides, readily form stable monolayers at the air-water interface, the most common experimental model for the oil-water interface. [44][45][46][47][48][49] The amphiphilicity of Aβ is itself a cause of its self-association. Several authors have noted the micelle-like nature of some Aβ soluble oligomers, [50][51][52][53][54] and in fibrils, the parallel, in-register nature of the β-sheets tends to minimize the exposure of the hydrophobic domains to the aqueous medium.…”

Section: Effects Of Lipid Surfaces and Other Amphiphilic Or Hydrophmentioning

confidence: 99%

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β‐Amyloid aggregation and heterogeneous nucleation

et al. 2019

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In this article, we consider the role of heterogeneous nucleation in β‐amyloid aggregation. Heterogeneous nucleation is more common and occurs at lower levels of supersaturation than homogeneous nucleation. The nucleation period is also the stage at which most of the polymorphism of amyloids arises, this being one of the defining features of amyloids. We focus on several well‐known heterogeneous nucleators of β‐amyloid, including lipid surfaces, especially those enriched in gangliosides and cholesterol, and divalent metal ions. These two broad classes of nucleators affect β‐amyloid particularly in light of the amphiphilicity of these peptides: the N‐terminal region, which is largely polar and charged, contains the metal binding site, whereas the C‐terminal region is aliphatic and is important in lipid binding. Notably, these two classes of nucleators can interact cooperatively, aggregation begetting greater aggregation.

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Section: Effects Of Lipid Surfaces and Other Amphiphilic Or Hydrophobmentioning

confidence: 99%

Section: Effects Of Lipid Surfaces and Other Amphiphilic Or Hydrophmentioning

confidence: 99%

β‐Amyloid aggregation and heterogeneous nucleation

et al. 2019

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“…The obtained −1 values were below 50 mN/m, indicating a liquidexpanded phase, and a change in the phase-state of the lipid on the air-water interface was not due to any change of the π-A isotherms [41]. Even at low surface pressures, the compressibility module is not directly linked with its true rheological and shear properties [42].…”

Section: Determination Of Elasticity Modulus and Surface Compressibilmentioning

confidence: 88%

Characterization of Monoolein Langmuir Monolayers Spread at The Salt Solution/Air Interface

Dhopte

Lad

2021

Preprint

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The Langmuir monolayer is commonly described at interfaces for an insoluble homogenous single molecular layer. Langmuir monolayers have demonstrated various issues regarding soft matters and complex fluids by forming ideal uniform two-dimensional structures over the air-water interface. This monolayer has advantages for evaluating physicochemical properties at interfaces and, for the insoluble molecules, can be applied simultaneously to the different interaction occurrences at interfaces. For this experiment, monoolein lipid was used as a spreading solvent to create a Langmuir monolayer, and five different types of salt sub-phases were applied for the physicochemical properties’ interaction studies. On the air-water interface, the surface properties of monoolein lipids were investigated for interfacial phase behaviors, using the Wilhelmy plate pressure sensor technique compression isotherm (π-A). Data and analysis were also contributed to the correspondent, precise verification of physical state behavior with the surface pressure measurements on the interfaces through the compressibility modulus and the elasticity modulus parameters on the surface. In the experiments, the interfacial activity of the monoolein lipids was found to be stable on the aqueous sub-phase, while the area per molecule over the interface did not have much impact as a sub-phase with a change in salts. The repeatability and reproducibility of tests were affirmed by the difference in the Langmuir monolayer’s particular phase transition orientation behavior and the stability of colloidal lipid dispersion. However, Langmuir monolayer formation contributes to several special groups being restructured and is found to be a more remarkable natural process for their attractive organic dynamic structural properties over the interface, but the interfacial molecular dynamics have proven to be difficult to calculate.

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“…The investigation of interfacial rheology is applied to understand the viscoelastic properties, which provide the modulus and relaxation behaviour [190] and to gain information about the structure-rheology interplay. The two-dimensional properties for a variety of systems like synthetic (co)polymers [115,191,192], mixed protein layers [193], biomolecules [45,194,195] and low molecular weight molecules [196] have been performed. However, investigations on pure protein layers and their interaction with water-soluble molecules are still challenging.…”

Section: Discussionmentioning

confidence: 99%

“…Low molecular weight amphiphiles, including (phospho)lipids and organic surfactants, are used initially for the formation of Langmuir layers due to their appropriate hydrophilichydrophobic balance, enabling the molecular orientation at the air-water interface. In the middle of the twentieth century, the idea of Langmuir monolayers was extended towards the description of the film formation of non-classical amphiphilic materials, such as (poly)peptides [44,45], proteins, [46] polysaccharides [47], nanoparticles [48], dyes [49,50], fullerenes [51][52][53] and (biodegradable) polymers [54,55].…”

Section: General Principlesmentioning

confidence: 99%

Evaluating polymeric biomaterial–environment interfaces by Langmuir monolayer techniques

Schöne

Roch

Schulz

et al. 2017

J. R. Soc. Interface.

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Polymeric biomaterials are of specific relevance in medical and pharmaceutical applications due to their wide range of tailorable properties and functionalities. The knowledge about interactions of biomaterials with their biological environment is of crucial importance for developing highly sophisticated medical devices. To achieve optimal performance, a description at the molecular level is required to gain better understanding about the surface of synthetic materials for tailoring their properties. This is still challenging and requires the comprehensive characterization of morphological structures, polymer chain arrangements and degradation behaviour. The review discusses selected aspects for evaluating polymeric biomaterial-environment interfaces by Langmuir monolayer methods as powerful techniques for studying interfacial properties, such as morphological and degradation processes. The combination of spectroscopic, microscopic and scattering methods with the Langmuir techniques adapted to polymers can substantially improve the understanding of their behaviour.

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The rheological properties of beta amyloid Langmuir monolayers: Comparative studies with melittin peptide

Cited by 17 publications

References 43 publications

β‐Amyloid aggregation and heterogeneous nucleation

β‐Amyloid aggregation and heterogeneous nucleation

Characterization of Monoolein Langmuir Monolayers Spread at The Salt Solution/Air Interface

Evaluating polymeric biomaterial–environment interfaces by Langmuir monolayer techniques

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