PT Tirta Investama Klaten Factory is a company that produces bottled drinking water. Most production activities use machines, but there are still activities carried out manually, namely in the packing area during box lifting activities. Box lifting activities that are carried out repeatedly over a certain period can potentially cause occupational diseases, namely musculoskeletal disorders. After conducting initial interviews with workers, it was discovered that workers in the packing area felt pain and tingling in their bodies. Based on these problems, it is necessary to measure and evaluate potential ergonomic hazards to identify potential health and worker protection problems due to ergonomic hazards. The method used SNI 9011:2021, a tool for measuring and evaluating potential ergonomic hazards in the workplace, and used QEC (Quick Exposure Checklist) to measure posture load from two points of view. The research results showed that the box lifting activity had the worst percentage exposure value of 76.14% and the worst ERF score of 7 (hazardous conditions). Apart from having an awkward posture, the results showed that symptoms of musculoskeletal disorders experienced by workers were also caused by factors such as age and length of service.