The risk of aseptic meningitis associated with the Leningrad-Zagreb mumps vaccine strain following mass vaccination with measles-mumps-rubella vaccine, Rio Grande do Sul, Brazil, 1997

Silveira, C. M.; Kmetzsch, Claudete Iris; Mohrdieck, Renate; Sperb, Alethea Fagundes; Prevots, D. Rebecca

doi:10.1093/ije/31.5.978

Cited by 54 publications

(20 citation statements)

References 10 publications

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“…84 SAEFI systems constitute an excellent instrument for maintaining the credibility of such campaigns, 112 as well as an opportunity to study rare AEFIs, given that the large number of vaccines administered in a short period of time increases the sensitivity of surveillance. 4,29,30,35,93 However, vaccination campaigns can potentially favor an increase in the perception of the risk associated with vaccination, 30 and may lead to an increase in programmatic errors, given that teams that participate in such campaigns may be less experienced. 36,84,112 Novel technologies, such as the use of bar-coded vaccine vials, allow for greater accuracy, easier registration of administered doses, and better identifi cation of the vaccine batch used.…”

Section: Strategies To Improve the Accuracy Of Saefi Systemsmentioning

confidence: 99%

Vigilância de eventos adversos pós-vacinação e segurança de programas de imunização

et al. 2011

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The aim of the review was to analyze conceptual and operational aspects of systems for surveillance of adverse events following immunization. Articles available in electronic format were included, published between 1985 and 2009, selected from the PubMed/Medline databases using the key words "adverse events following vaccine surveillance", "post-marketing surveillance", "safety vaccine" and "Phase IV clinical trials".Articles focusing on specifi c adverse events were excluded.The major aspects underlying the Public Health importance of adverse events following vaccination, the instruments aimed at ensuring vaccine safety, and the purpose, attributes, types, data interpretation issues, limitations, and further challenges in adverse events following immunization were describe, as well as strategies to improve sensitivity.The review was concluded by discussing the challenges to be faced in coming years with respect to ensuring the safety and reliability of vaccination programs.

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Section: Strategies To Improve the Accuracy Of Saefi Systemsmentioning

confidence: 99%

Vigilância de eventos adversos pós-vacinação e segurança de programas de imunização

et al. 2011

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“…Some states had to conduct mass vaccination campaigns, and the states used two of the MMR vaccines that we had studied, vaccine A and vaccine C. Thousands of doses were applied in a short period of time. After the campaigns, there was a significant increase in post-vaccination adverse events, among them many cases of aseptic meningitis (22,23). The estimated risk of aseptic meningitis found associated with vaccine A in Rio Grande do Sul was 1 case per 3 390 applied doses (22).…”

Section: Discussionmentioning

confidence: 99%

“…After the campaigns, there was a significant increase in post-vaccination adverse events, among them many cases of aseptic meningitis (22,23). The estimated risk of aseptic meningitis found associated with vaccine A in Rio Grande do Sul was 1 case per 3 390 applied doses (22). In the city of Salvador, Bahia, the risk associated with vaccine C was 1 case per 14 000 applied doses (23).…”

Section: Discussionmentioning

confidence: 99%

An evaluation of the adverse reaction potential of three measles-mumps-rubella combination vaccines

Santos¹,

Ranieri²,

Bercini³

et al. 2002

Rev Panam Salud Publica

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“…Despite some safety concerns reported from Brazil, the preparation is believed to be safe, as subsequent studies have reported that the rate of serious adverse events following this extensively used preparation is low [22][23][24][25][26][27]. This observation was supported by the World Health Organization and individual authors [11,28,29].…”

Section: Introductionmentioning

confidence: 96%

Active safety monitoring of measles-mumps-rubella vaccine in the National Immunisation Programme of Sri Lanka

et al. 2017

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Objectives This study was designed to report incidence and characteristics of selected adverse events following immunisation which have consistent causal association (AEFIc) with Measles-Mumps-Rubella (MMR) vaccination given at the age of one year in the National Immunisation Programme of Sri Lanka.Methods The data presented here were obtained from a cohort event monitoring study. It was carried out in the Jaffna Regional Directorate of Health Services area from November 2012 to December 2014. A representative sample of 3002 infants who received MMR immunisation were actively followed up for adverse events (AE) using over the phone interviews, self-reporting, and home or hospital visits up to 45 days. All AEs were reviewed by two investigators independently in two step-wise processes to detect the AEFIc. Seven AEFIc were detected using standard case definitions and onset time limit criteria. They were subjected to further analysis to describe the incidence rates and characteristics.Results Of the 2398 (80%) infants who completed follow up of 45 days, 1321 infants experienced 2621 AEFI. Of them 209 were classified as AEFIc. Incidence of AEFIc was 87/ 1000 immunisation. They were mainly nonserious and resolved completely. There were no fatal or life threatening AEFIs. Incidence per 1000 immunisations; allergic reactions 0.83, injection site reactions 4.58, fever100.4° F or lasting more than  3 days 9.59, macular papular rash 2.92, parotitis 2.92 and generalised convulsions 1.25. ConclusionThe MMR vaccine used in NIP of Sri Lanka had low incidence of AEFIc and were mainly non-serious in nature.

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The risk of aseptic meningitis associated with the Leningrad-Zagreb mumps vaccine strain following mass vaccination with measles-mumps-rubella vaccine, Rio Grande do Sul, Brazil, 1997

Abstract: Vaccination with the L-Z strain of mumps vaccine as part of a mass campaign was associated with a significantly increased risk of aseptic meningitis. Decisions about type of mumps vaccine and mumps vaccination strategies must consider vaccine safety issues in addition to other criteria.

Cited by 54 publications

References 10 publications

Vigilância de eventos adversos pós-vacinação e segurança de programas de imunização

Vigilância de eventos adversos pós-vacinação e segurança de programas de imunização

An evaluation of the adverse reaction potential of three measles-mumps-rubella combination vaccines

Active safety monitoring of measles-mumps-rubella vaccine in the National Immunisation Programme of Sri Lanka

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