The Risk of Birth Defects in Dichorionic Twins Conceived by Assisted Reproductive Technology

Kuwata, Tomoyuki; Matsubara, Shigeki; Ohkuchi, Akihide; Watanabe, Takashi; Izumi, Akio; Honma, Yoko; Yada, Yukari; Shibahara, Hiroaki; Suzuki, Michitaka

doi:10.1375/twin.7.3.223

Cited by 5 publications

(9 citation statements)

References 15 publications

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“…The woman underwent ICSI and became pregnant. Many studies suggest that children born after ICSI have an increased risk of a major congenital malformation compared with those born after spontaneous conception 7–10 …”

Section: Discussionmentioning

confidence: 99%

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Dichorionic twin fetuses with VACTERL association

Sunagawa¹,

Kikuchi²,

Shiro³

et al. 2007

J of Obstet and Gynaecol

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Although prenatal diagnosis of VACTERL (vertebral defects, anal atresia, cardiac anomaly, tracheal-esophageal fistula with esophageal atresia, renal defects, and radial limb dysplasia) association is not always possible, ultrasonography and magnetic resonance imaging can visualize some of the characteristic findings of this condition. Because infants with this condition usually require significant surgical treatment and care, prenatal detection with those imaging modalities should assist in proper planning for delivery and anticipated care of the neonate. In this report, we present dichorionic twin fetuses, both of whom were found postnatally to have this condition, and suggest the possible relationship between this disorder and intracytoplasmic sperm injection. As far as we know, this is the first report of twin fetuses affected by VACTERL association.

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Section: Discussionmentioning

confidence: 99%

“…Kuwata et al . reported that the incidence of birth defects in dichorionic twins conceived by assisted reproductive technology (ART; ICSI, in vitro fertilization [IVF] or gamete‐intrafallopian tube transfer [GIFT]) was significantly higher than that of naturally conceived twins 10 …”

Section: Discussionmentioning

confidence: 99%

Dichorionic twin fetuses with VACTERL association

Sunagawa¹,

Kikuchi²,

Shiro³

et al. 2007

J of Obstet and Gynaecol

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“…Congenital malformations (CM) are common and complex adverse pregnancy outcomes associated with perinatal or infant mortality and morbidity throughout the world (Levi Setti et al, 2016). Data available from registry-based cohort studies (Hu, 2012;Kuwata et al, 2004;Liberman et al, 2017;Sagot et al, 2012) and our previous two reviews (Qin et al, 2015a(Qin et al, , 2015b has confirmed that the multiple pregnancies created with IVF/ICSI were significantly associated with the risk of developing CM in their offspring, when compared with their spontaneously conceived (SC) counterparts. However, it remains unknown which type of CM is significantly increased among the multiple pregnancies following IVF/ICSI.…”

Section: Introductionmentioning

confidence: 76%

“…Finally, 21 cohort studies were included for analysis (Boulet et al, 2016;Çakar et al, 2014;Davies et al, 2012;Dhont et al, 1997;Fedder et al, 2013;Hansen et al, 2012;Hu, 2012;Isaksson et al, 2002;Jwa et al, 2015;Klemetti et al, 2005;Koudstaal et al, 2000;Kuwata et al, 2004;Liberman et al, 2017;Manoura et al, 2004;Olson et al, 2005;Pinborg et al, 2004;Sagot et al, 2012;Saygan-Karamürsel et al, 2006;Vasario et al, 2010;Wen et al, 2010;Yang et al, 2011).…”

Section: Literature Searchmentioning

confidence: 99%

“…Three studies (Boulet et al, 2016;Hu, 2012;Pinborg et al, 2004) only included live births, four studies (Davies et al, 2012;Hansen et al, 2012;Jwa et al, 2015;Sagot et al, 2012) included live births, stillbirths and terminations of pregnancy for fetal anomaly, and the remaining included live births and stillbirths but no terminations of pregnancy for fetal anomaly (Çakar et al, 2014;Dhont et al, 1997;Fedder et al, 2013;Isaksson et al, 2002;Klemetti et al, 2005;Koudstaal et al, 2000;Kuwata et al, 2004;Liberman et al, 2017;Manoura et al, 2004;Olson et al, 2005;Saygan-Karamürsel et al, 2006;Vasario et al, 2010;Wen et al, 2010;Yang et al, 2011). Total number of IVF/ICSI and SC multiple births involved for each specific CM is summarized in Supplementary Table S2. IVF/ICSI and risk of cleft lip and/or palate, eye, ear, face and neck, and respiratory system malformations Figure 2 shows the results from the fixed-effects model combining the RR for cleft lip and/or palate, eye, ear, face and neck, and respiratory system malformations.…”

Section: Study Characteristicsmentioning

confidence: 99%

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Multiple pregnancies achieved with IVF/ICSI and risk of specific congenital malformations: a meta-analysis of cohort studies

Zheng

Chen

Yang

et al. 2018

Reproductive BioMedicine Online

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Studies comparing risk of specific congenital malformations (CM) between multiple pregnancies resulting from IVF/intracytoplasmic sperm injection (ICSI) and those conceived naturally report conflicting results; furthermore, there is a lack of a complete overview. This meta-analysis aimed to address which types of CM are increased in IVF/ICSI multiple pregnancies compared with those conceived naturally. All studies testing the association between IVF/ICSI multiple pregnancies and specific CM identified in various databases were considered. The literature search yielded 856 records, of which 21 cohort studies were included for analysis. Overall, multiple pregnancies achieved with IVF/ICSI experienced a significantly higher risk of chromosomal defects (relative risk [RR] = 1.36; 95% confidence interval [CI]: 1.04-1.77), urogenital (RR = 1.18; 95% CI: 1.03-1.36) and circulatory (RR = 1.22; 95% CI: 1.01-1.47) system malformations. However, the remaining specific CM, such as cleft lip and/or palate, eye, ear, face and neck, respiratory, musculoskeletal, nervous and digestive system malformations, were similar in the two groups. No substantial heterogeneity was observed for most outcomes except for digestive (P = 0.094; I = 38.3%) and circulatory (P = 0.070; I = 35.2%) system malformations. These findings provide additional information on risks of IVF/ICSI for use when counselling patients.

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Twin Studies of General Mental Ability

Segal

Johnson

2009

Handbook of Behavior Genetics

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The Risk of Birth Defects in Dichorionic Twins Conceived by Assisted Reproductive Technology

Cited by 5 publications

References 15 publications

Dichorionic twin fetuses with VACTERL association

Dichorionic twin fetuses with VACTERL association

Multiple pregnancies achieved with IVF/ICSI and risk of specific congenital malformations: a meta-analysis of cohort studies

Twin Studies of General Mental Ability

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