The risk of contamination of food with toxic substances present in animal feed

Kan, C.A.; Meijer, G.A.L.

doi:10.1016/j.anifeedsci.2006.08.005

Cited by 185 publications

(135 citation statements)

References 61 publications

Supporting

Mentioning

123

Contrasting

Unclassified

Order By: Relevance

“…com. are metabolized into naturally occurring and generally harmless constituents. Most veterinary drugs and feed additives fall into this group (Kan and Meijer, 2007). Some mycotoxins were heat stable up to as much as 400°C.…”

Section: Introductionmentioning

confidence: 99%

“…Several of the major mycotoxins exert their effects through different organ systems and different biological pathways. Aflatoxin, ochratoxin, and T-2 toxin all interfere with protein formation, but each does so in a different manner; aflatoxin binds to both RNA and DNA and blocks transcription (Kan and Meijer, 2007). T-2 toxin blocks initiation of translation, and ochratoxin blocks phenylalanine-t RNA synthetase, and thus blocks translation.…”

Section: Introductionmentioning

confidence: 99%

“…Adequate risk management depends on knowledge of absorption, metabolism, carry-over and toxicological profile of these substances and on practical measures to reduce them. Generally, toxic substances are metabolized before or after absorption through the intestinal tract (Kan and Meijer, 2007). Depending on their physico-chemical characteristics, some substances *Corresponding author.…”

Section: Introductionmentioning

confidence: 99%

“…T-2 toxin blocks initiation of translation, and ochratoxin blocks phenylalanine-t RNA synthetase, and thus blocks translation. Some scientists assume complete absorption of these noxious substances, as a worst-case scenario to predict residues in animal products from those in feed (Kan and Meijer, 2007). By doing so, they ignore the physiological processes occurring during transit through the intestine and after absorption into the general circulation as well as intermediary metabolism.…”

Section: Introductionmentioning

confidence: 99%

“…By doing so, they ignore the physiological processes occurring during transit through the intestine and after absorption into the general circulation as well as intermediary metabolism. Furthermore this approach does not take advantage of existing knowledge to identify or implement possible control points for reduction of levels of residues in animal products (Kan and Meijer, 2007).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Mycotoxins in animals: Occurrence, effects, prevention and management

Zaki¹

2012

J. Toxicol. Environ. Health Sci.

View full text Add to dashboard Cite

Globalization of the trade in agricultural commodities has contributed significantly to the discussion about potential hazards involved and has increased in particular the awareness of mycotoxins. Safety awareness in food and feed production has also risen due to the simple fact that methods for testing residues and undesirable substances have become noticeably more sophisticated and more available at all points of the supply chain. Mycotoxins comprise of a family of fungal toxins, many of which have been implicated as chemical progenitors of toxicity in man and animals. There are four classes of mycotoxins of major concern namely aflatoxins, zearalenone, ochratoxins, and fumonisins. Formation of mycotoxins varied between species as well as within a given species. A variety of physical, chemical, and biological methods to counteract the mycotoxin problem have been reported, but large-scale, practical, and cost-effective methods for detoxifying mycotoxin-containing feedstuffs are currently not available. Detoxification strategies for the contaminated foods and feeds should be done to reduce or eliminate the adverse actions of mycotoxin to improve food safety and prevent economic losses. The most recent approach to the problem has been the addition to the animal's diet of nonnutritive sorbents that sequester mycotoxins, reduce their gastrointestinal absorption and avoiding their toxic effects on livestock and toxin carryover into animal products. This review comments on the potential hazards of several mycotoxins together with prevention strategy for fungal and mycotoxin contamination.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations