The risk of developing non‐melanoma skin cancer, lymphoma and melanoma in patients with psoriasis in Taiwan: a 10‐year, population‐based cohort study

Lee, Meng-Sui; Lin, Ruey S.; Chang, Yu‐Sheng; Lai, Mei‐Shu

doi:10.1111/j.1365-4632.2011.05310.x

Cited by 35 publications

(29 citation statements)

References 43 publications

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“…Several studies showed that the NHIRD database is appropriate for use in pharmacoepidemiologic research [12, 16, 17]. The NHIRD database contains participant demographics and detail claim history, which includes medications prescribed, medications quantity, route of administration, individual diagnoses, operations, and outpatient and inpatient electronic claim records.…”

Section: Methodsmentioning

confidence: 99%

Risk of incident active tuberculosis disease in patients treated with non-steroidal anti-inflammatory drugs: a population-based study

Lee

et al. 2017

BMC Pulm Med

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Background Mycobacterium tuberculosis (TB) is one of the world’s most devastating public health threats. Our goal is to evaluate whether the use of non-steroidal anti-inflammatory drugs (NSAIDs) affect the risk of new incident active TB disease.MethodsWe conducted a nested case-control analysis by using a 1 million longitudinally followed cohort, from Taiwan’s national health insurance research database. Effects of NSAIDs on active TB were estimated by conditional logistic regression and adjusted using a TB-specific disease risk score (DRS). NSAIDs exposures were defined as having a prescription record of NSAIDs ≧ 7 days that ended between 31 and 90 days prior to the index date.ResultsA total of 123,419 users of traditional NSAIDs, 16,392 users of cyclooxygenase-2 selective inhibitor (Coxibs), and 4706 incident cases of active TB were identified. Compared with nonusers, use of traditional NSAIDs was associated with an increased risk of TB in the unadjusted analysis ([RR], 1.39; 95% [CI], 1.24 – 1.57 and DRS adjusted analysis ([ARR], 1.30; 95% [CI], 1.15– 1.47). However, use of Coxibs was not associated with a significant increase in the risk of TB after DRS adjustment ([ARR], 1.23; 95% [CI], 0.89 – 1.70).ConclusionsIn this large population-based study, we found that subjects using traditional NSAIDs were associated with increased risk for active TB. We did not find evidence for a causative mechanism between traditional NSAIDs and TB, and more research is required to verify whether the association between traditional NSAIDs and TB is causal, or simply reflects an increased use of anti-inflammatory drugs in the early phases of TB onset.Electronic supplementary materialThe online version of this article (doi:10.1186/s12890-017-0425-3) contains supplementary material, which is available to authorized users.

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Section: Methodsmentioning

confidence: 99%

Risk of incident active tuberculosis disease in patients treated with non-steroidal anti-inflammatory drugs: a population-based study

Lee

et al. 2017

BMC Pulm Med

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“…A cohort study of 7,061 Taiwanese psoriasis patients found that psoriasis patients were more likely to develop non-melanoma skin cancer and lymphoma 156. Patients who had never received systemic therapy were also more likely to develop non-melanoma skin cancer and lymphoma, suggesting that psoriasis could be an independent risk factor for these malignancies 156…”

Section: Cancermentioning

confidence: 99%

Psoriasis and comorbidities: links and risks

Ni¹,

Chiu²

2014

CCID

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Psoriasis is a chronic inflammatory skin disease affecting approximately 2% of the population worldwide. In the past decade, many studies have drawn attention to comorbid conditions in psoriasis. This literature review examines the epidemiological evidence, pathophysiological commonalities, and therapeutic implications for different comorbidities of psoriasis. Cardiovascular disease, obesity, diabetes, hypertension, dyslipidemia, metabolic syndrome, nonalcoholic fatty liver disease, cancer, anxiety and depression, and inflammatory bowel disease have been found at a higher prevalence in psoriasis patients compared to the general population. Because of the wide range of comorbid conditions associated with psoriasis, comprehensive screening and treatment must be implemented to most effectively manage psoriasis patients.

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“…[15][16][17] In addition, either because of their disease or treatments they might have or had received, patients with psoriasis are at increased risk for certain other diseases such as cancers, including lymphoma and skin cancer, [18][19][20] and autoimmune diseases. 2,[21][22][23][24][25] As patient information may inform clinical care, dermatologists need to obtain, document, and act on key pieces of information about patients with psoriasis to provide optimal care.…”

mentioning

confidence: 99%

Impact of a Performance Improvement CME activity on the care and treatment of patients with psoriasis

Gist¹,

Bhushan²,

Hamarstrom³

et al. 2015

Journal of the American Academy of Dermatology

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The risk of developing non‐melanoma skin cancer, lymphoma and melanoma in patients with psoriasis in Taiwan: a 10‐year, population‐based cohort study

Abstract: Psoriasis carries an elevated risk of NMSC and lymphoma. This effect is modified by the severity of psoriasis, age, gender, and geographic location.

Cited by 35 publications

References 43 publications

Risk of incident active tuberculosis disease in patients treated with non-steroidal anti-inflammatory drugs: a population-based study

Risk of incident active tuberculosis disease in patients treated with non-steroidal anti-inflammatory drugs: a population-based study

Psoriasis and comorbidities: links and risks

Impact of a Performance Improvement CME activity on the care and treatment of patients with psoriasis

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