The Risk of Emerging of Dengue Fever in Romania, in the Context of Global Warming

Ivanescu, Larisa Maria; Bodale, Ilie; Grigore-Hristodorescu, Smaranda; Martinescu, Gabriela; Andronic, Bianca; Matiut, Simona; Azoicăi, Doina; Miron, Liviu

doi:10.3390/tropicalmed8010065

Cited by 6 publications

(3 citation statements)

References 29 publications

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“…In Romania, since the mid-1980s, extremely high values for summer thermal stress that indicates an increased risk to human health during summers (Climate Change Post 2023). Another aspect is the risk of infectious diseases spreading beyond tropical regions to temperate zones, for example "dengue fever, Chagas, leishmaniasis, Chikungunya, schistoso-miasis" (Ivanescu 2023). Climate change effects' health risks are mostly affecting vulnerable categories of people like children, pregnant women, elderly people and people with chronic conditions and people from disadvantaged areas with poor access to financial means, medical aid and other social services.…”

Section: Part Of Ecological Threats and Risks Associated To Climate C...mentioning

confidence: 99%

Vulnerabilities Transposed by Climate Change Effects in Ecological Risks and Threats to the National Security

ATANASIU

2024

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Climate changes effects determine major transformations of interactions between socio-economic and natural environment, phenomena that directly affect the overall security (international, national, regional) systems. In the security equation, vulnerabilities in different sectors expose systems to threats and associated risks and their existence represents gaps and malfunctions in assuring systems’ overall resilience. In this paper, we start from the research hypothesis that vulnerabilities are a constitutive element of the climate security equation seen as a logical construction of a causal nature, respectively: the effects of climate changes are the source of ecological threats and associated risks facilitated or multiplied by exploited vulnerabilities whose presence/absence gives the measure of the impact over the respective security system. In this regard, our topic is focused on a narrower subject, namely the identification of vulnerabilities that have the potential to be exploited in generating ecological threats and associated risks against Romanian national security. In order to achieve our goal, concepts like “environmental security”, “climate security”, “ecology”, “climate change”, “vulnerability”, “ecological risks and threats”, and “resilience” will be approached in the capacity of their interdisciplinary entanglement between security and ecology.

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Section: Part Of Ecological Threats and Risks Associated To Climate C...mentioning

confidence: 99%

Vulnerabilities Transposed by Climate Change Effects in Ecological Risks and Threats to the National Security

ATANASIU

2024

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“…During the first months of 2024, several countries and territories of Latin America have reported an unprecedented surge in dengue cases. Furthermore, reports of dengue virus infection and autochthonous transmission are rapidly becoming an increasing concern in countries in mainland Europe, presumably due to the changing climate and thereby altered territory of dengue virus vectors ( 3 , 4 ). As of 2022, the World Health Organization estimates that approximately 100-400 million infections occur per year, although over 80% of those are mild and asymptomatic ( 1 ).…”

Section: Introductionmentioning

confidence: 99%

Dengue virus exploits autophagy vesicles and secretory pathways to promote transmission by human dendritic cells

Cloherty,

Rader,

Patel

et al. 2024

Front. Immunol.

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Dengue virus (DENV), transmitted by infected mosquitoes, is a major public health concern, with approximately half the world’s population at risk for infection. Recent decades have increasing incidence of dengue-associated disease alongside growing frequency of outbreaks. Although promising progress has been made in anti-DENV immunizations, post-infection treatment remains limited to non-specific supportive treatments. Development of antiviral therapeutics is thus required to limit DENV dissemination in humans and to help control the severity of outbreaks. Dendritic cells (DCs) are amongst the first cells to encounter DENV upon injection into the human skin mucosa, and thereafter promote systemic viral dissemination to additional human target cells. Autophagy is a vesicle trafficking pathway involving the formation of cytosolic autophagosomes, and recent reports have highlighted the extensive manipulation of autophagy by flaviviruses, including DENV, for viral replication. However, the temporal profiling and function of autophagy activity in DENV infection and transmission by human primary DCs remains poorly understood. Herein, we demonstrate that mechanisms of autophagosome formation and extracellular vesicle (EV) release have a pro-viral role in DC-mediated DENV transmission. We show that DENV exploits early-stage canonical autophagy to establish infection in primary human DCs. DENV replication enhanced autophagosome formation in primary human DCs, and intrinsically-heightened autophagosome biogenesis correlated with relatively higher rates of DC susceptibility to DENV. Furthermore, our data suggest that viral replication intermediates co-localize with autophagosomes, while productive DENV infection introduces a block at the late degradative stages of autophagy in infected DCs but not in uninfected bystander cells. Notably, we identify for the first time that approximately one-fourth of DC-derived CD9/CD81/CD63+ EVs co-express canonical autophagy marker LC3, and demonstrate that DC-derived EV populations are an alternative, cell-free mechanism by which DCs promote DENV transmission to additional target sites. Taken together, our study highlights intersections between autophagy and secretory pathways during viral infection, and puts forward autophagosome accumulation and viral RNA-laden EVs as host determinants of DC-mediated DENV infection in humans. Host-directed therapeutics targeting autophagy and exocytosis pathways thus have potential to enhance DC-driven resistance to DENV acquisition and thereby limit viral dissemination by initial human target cells following mosquito-to-human transmission of DENV.

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“…Uno de los vectores que ha generado más preocupación en los últimos años, dada su rápida dispersión y fácil adaptabilidad, es el "mosquito tigre asiático" Aedes albopictus 3 , 4 . Originario del sureste asiático, es considerado actualmente como el mosquito más invasivo del mundo y es catalogado como uno de los vectores con mayor dispersión geográfica en las últimas dos décadas 5 .…”

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Distribución de Aedes albopictus en Ibagué: potencial riesgo de brotes de arbovirosis

Canizales,

Carranza,

Vallejo

et al. 2023

biomedica

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Introducción. Aedes albopictus es un vector de arbovirus como dengue, Zika, chikungunya y fiebre amarilla. Los primeros reportes en el continente americano datan de 1985 y dada su capacidad de adaptación ecológica y fisiológica, se ha distribuido rápidamente en el territorio colombiano desde su primer reporte en 1998.Objetivo. Determinar la distribución de A. albopictus en las comunas de Ibagué, Colombia.Materiales y métodos. Los muestreos se realizaron entre mayo y noviembre de 2022 en zonas con abundante vegetación de las 13 comunas de Ibagué. Se emplearon aspiradores y redes entomológicas. Los mosquitos fueron transportados al Laboratorio de Investigaciones en Parasitología Tropical de la Universidad del Tolima para su determinación taxonómica.Resultados. Se identificaron 708 ejemplares de A. lbopictus, distribuidos en las comunas de Ibagué. La mayor abundancia del vector se presentó en las comunas 10, 11, 7, 8, 2 y 9. Las comunas 3, 4, 5, 6, 12 y 13 presentaron abundancias relativas cercanas al 3 %, y la comuna 1 tuvo una abundancia del 2 %.Conclusiones. Aedes albopictus está distribuido en todas las comunas de Ibagué, probablemente su dispersión se ha visto favorecida por las condiciones ambientales y sociales de esta región. Se recomienda hacer seguimiento anual a las poblaciones de este vector y realizar una caracterización molecular de los arbovirus encontrados. Además, el conocer la distribución de este mosquito en la ciudad permitirá focalizar las estrategias de control entomológico y prevenir futuros brotes de arbovirosis.

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The Risk of Emerging of Dengue Fever in Romania, in the Context of Global Warming

Cited by 6 publications

References 29 publications

Vulnerabilities Transposed by Climate Change Effects in Ecological Risks and Threats to the National Security

Vulnerabilities Transposed by Climate Change Effects in Ecological Risks and Threats to the National Security

Dengue virus exploits autophagy vesicles and secretory pathways to promote transmission by human dendritic cells

Distribución de Aedes albopictus en Ibagué: potencial riesgo de brotes de arbovirosis

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