The risk of rheumatoid arthritis among patients with inflammatory bowel disease: a systematic review and meta-analysis

Chen, Yi; Chen, Lang; Xing, Changsheng; Deng, Guangtong; Zeng, Furong; Xie, Tingting; Gu, Lei; Yang, Hui

doi:10.1186/s12876-020-01339-3

Cited by 26 publications

(21 citation statements)

References 59 publications

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“…Contrary to our expectations, patients with ulcerative colitis had a greater prevalence of RA in their histories [ 27 , 28 ]. This conflicts with the data presented in the systematic review and meta-analysis, conducted by Chen and coworkers (BMC Gastroenterology 2020 [ 29 ]). As they included eight studies in their meta-analysis, and indeed, most of the studies reported RA to be more prevalent in Crohn’s disease, we believe that perhaps our sample was too small in size to observe this phenomenon.…”

Section: Discussionmentioning

confidence: 57%

Contrasting Autoimmune Comorbidities in Microscopic Colitis and Inflammatory Bowel Diseases

Fedor

Zöld

Barta

2023

Life

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Background: Inflammatory bowel diseases (Crohn’s disease and ulcerative colitis) and microscopic colitis (lymphocytic and collagenous colitis) are immune-mediated diseases of the gastrointestinal tract, with distinct pathophysiology. Objective: We sought to compare the prevalence of autoimmune diseases between microscopic colitis (MC) and inflammatory bowel diseases (IBDs) in our patient cohorts in their medical history. Methods: We collected data from 611 patients (508 with IBD, 103 with MC). We recorded cases of other autoimmune diseases. The screened documentation was written in the period between 2008 and 2022. We sought to determine whether colonic involvement had an impact on the prevalence of autoimmune diseases. Results: Ulcerative colitis patients and patients with colonic-predominant Crohn’s disease had a greater propensity for autoimmune conditions across the disease course than patients with ileal-predominant Crohn’s disease. Gluten-related disorders were more common in Crohn’s disease than in ulcerative colitis, and slightly more common than in microscopic colitis. In ulcerative colitis, 10 patients had non-differentiated collagenosis registered, which can later develop into a definite autoimmune disease. Conclusions: Predominantly colonic involvement can be a predisposing factor for developing additional autoimmune disorders in IBD. Ulcerative colitis patients may have laboratory markers of autoimmunity, without fulfilling the diagnostic criteria for definitive autoimmune disorders (non-differentiated collagenosis).

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Section: Discussionmentioning

confidence: 57%

Contrasting Autoimmune Comorbidities in Microscopic Colitis and Inflammatory Bowel Diseases

Fedor

Zöld

Barta

2023

Life

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“…For example, perinuclear anti-neutrophil cytoplasmic autoantibodies (p-ANCA) have been found in 26% to 85% of PSC patients and up to 68% of UC patients ( 42 , 43 ). In recent years, an increasing number of studies have noted that rheumatoid arthritis (RA) tended to cluster with IBD ( 44 , 45 ) and that patients with IBD are more likely to develop RA ( 46 ). In addition, anemia is one of the most common extraintestinal systemic complications of IBD, affecting approximately 41-75% of children with IBD ( 47 ).…”

Section: Discussionmentioning

confidence: 99%

Research hotspot and trend analysis in the diagnosis of inflammatory bowel disease: A machine learning bibliometric analysis from 2012 to 2021

Liu

Zhang

et al. 2022

Front. Immunol.

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AimsThis study aimed to conduct a bibliometric analysis of the relevant literature on the diagnosis of inflammatory bowel disease (IBD), and show its current status, hot spots, and development trends.MethodsThe literature on IBD diagnosis was acquired from the Science Citation Index Expanded of the Web of Science Core Collection. Co-occurrence and cooperation relationship analysis of authors, institutions, countries, journals, references, and keywords in the literature were carried out through CiteSpace software and the Online Analysis platform of Literature Metrology. At the same time, the relevant knowledge maps were drawn, and the keywords cluster analysis and emergence analysis were performed.Results14,742 related articles were included, showing that the number of articles in this field has increased in recent years. The results showed that PEYRIN-BIROULET L from the University Hospital of Nancy-Brabois was the author with the most cumulative number of articles. The institution with the most articles was Mayo Clin, and the United States was far ahead in the article output and had a dominant role. Keywords analysis showed that there was a total of 818 keywords, which were mainly focused on the research of related diseases caused or coexisted by IBD, such as colorectal cancer and autoimmune diseases, and the diagnosis and treatment methods of IBD. Emerging analysis showed that future research hotspots and trends might be the treatment of IBD and precision medicine.ConclusionThis research was the first bibliometric analysis of publications in the field of IBD diagnosis using visualization software and data information mining, and obtained the current status, hotspots, and development of this field. The future research hotspot might be the precision medicine of IBD, and the mechanism needed to be explored in depth to provide a theoretical basis for its clinical application.

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“…This could be the case of patients that have undertaken biologic drugs for other immune mediated inflammatory conditions (IMIDs), whose diagnosis occurred earlier than RA. This possibility is not uncommon since RA patients frequently had history of Crohn's disease, ulcerative colitis or psoriasis 11 , 12 . Moreover, this could also explain the dispensation of the first bDMARD before diagnosis of RA, observed in some patients.…”

Section: Discussionmentioning

confidence: 99%

Validation of algorithms for selecting rheumatoid arthritis patients in the Tuscan healthcare administrative databases

Convertino

Cazzato

Giometto

et al. 2021

Sci Rep

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Validation of algorithms for selecting patients from healthcare administrative databases (HAD) is recommended. This PATHFINDER study section is aimed at testing algorithms to select rheumatoid arthritis (RA) patients from Tuscan HAD (THAD) and assessing RA diagnosis time interval between the medical chart date and that of THAD. A population was extracted from THAD. The information of the medical charts at the Rheumatology Unit of Pisa University Hospital represented the reference. We included first ever users of biologic disease modifying anti-rheumatic drugs (bDMARDs) between 2014 and 2016 (index date) with at least a specialist visit at the Rheumatology Unit of the Pisa University Hospital recorded from 2013 to the index date. Out of these, we tested four index tests (algorithms): (1) RA according to hospital discharge records or emergency department admissions (ICD-9 code, 714*); (2) RA according to exemption code from co-payment (006); (3) RA according to hospital discharge records or emergency department admissions AND RA according to exemption code from co-payment; (4) RA according to hospital discharge records or emergency department admissions OR RA according to exemption code from co-payment. We estimated sensitivity, specificity, positive and negative predicted values (PPV and NPV) with 95% confidence interval (95% CI) and the RA diagnosis median time interval (interquartile range, IQR). Two sensitivity analyses were performed. Among 277 reference patients, 103 had RA. The fourth algorithm identified 96 true RA patients, PPV 0.78 (95% CI 0.70–0.85), sensitivity 0.93 (95% CI 0.86–0.97), specificity 0.84 (95% CI 0.78–0.90), and NPV 0.95 (95% CI 0.91–0.98). The sensitivity analyses confirmed performance. The time measured between the actual RA diagnosis date recorded in medical charts and that assumed in THAD was 2.2 years (IQR 0.5–8.4). In conclusion, this validation showed the fourth algorithm as the best. The time interval elapsed between the actual RA diagnosis date in medical charts and that extrapolated from THAD has to be considered in the design of future studies.

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The risk of rheumatoid arthritis among patients with inflammatory bowel disease: a systematic review and meta-analysis

Cited by 26 publications

References 59 publications

Contrasting Autoimmune Comorbidities in Microscopic Colitis and Inflammatory Bowel Diseases

Contrasting Autoimmune Comorbidities in Microscopic Colitis and Inflammatory Bowel Diseases

Research hotspot and trend analysis in the diagnosis of inflammatory bowel disease: A machine learning bibliometric analysis from 2012 to 2021

Validation of algorithms for selecting rheumatoid arthritis patients in the Tuscan healthcare administrative databases

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