The Risk of Venipuncture in Newborn with Severe Hemophilia: Case Report of a Large Elbow Hemorrhage and Literature Review of Compartment Syndrome

Abstract

Hemophilias are hemorrhagic congenital rare diseases. The gold standard of therapy in hemophilics is the intravenously replacement therapy. We can infuse intravenously plasma derived factors (FVIII for Hemophilia A and FIX for Hemophilia B) or recombinant products (i.e. clotting factor synthetically produced). Venipuncture is not a safe procedure in subjects with hemorrhagic diseases. It is considered an invasive technique with potential massive bleeding and it requires standardized procedures to prevent complications. Local pressure after the procedure (with eventually ice rest) must be always done. In case of bleeding a rapid replacement therapy must be conducted. A severe complication in hemophilia is compartment syndrome. We report a case of massive bleeding in a hemophilic newborn after venipuncture and a literature review of compartment syndrome in hemophiliacs. The aim of this paper is to help physicians in the clinical management to prevent the evolution of a massive bleeding in compartment syndrome.

Microneedle-based sampling of dermal interstitial fluid using a vacuum-assisted skin patch

“…While blood sampling is a routine medical procedure, it poses risks of infection 1 and can lead to complications in infants and individuals with blood clotting disorders. 2 Furthermore, the pain associated with blood sampling can deter individuals with needle or blood phobias from getting tested. 1 Urine and saliva are less invasive and easier to collect; however, these fluids contain only subsets of the biomarkers found in blood, 3 typically at significantly lower concentrations, 4 hindering their use for many diagnostic applications.…”

Biologically Derived Nanoarchitectonic Coatings for the Engineering of Hemostatic Needles

“…Various hemostatic agents (e.g., powder and hydrogels) have been widely designed for the wound hemorrhage. − In some cases, bleeding after tissue puncture with syringe needles could cause psychological fear in patients, especially for children. Further, it increases the risk of local or systemic complications (e.g., subcutaneous bruises, swelling, nerve damage, and uncontrolled bleeding) in patients suffering from hemophilia, Von Willebrand disease, vitamin K deficiency, rat poisoning, warfarin poisoning, and disseminated intravascular coagulation. , Recently, a self-sealing hemostatic needle coated with catechol-conjugated chitosan has been reported for antibleeding after tissue puncture via solid-to-gel phase transition of catechol-functionalized chitosan. , However, the preparation process of hemostatic needles either involved complex modification of polymers or an oxidative preincubation process of 3 days to achieve hemostatic functions. Sodium alginate and CaCl 2 have been also used to decorate hypodermic needles, which also exhibit hemostasis during tissue puncture. , Nevertheless, the coating detached from the needle surface only serves as a physical barrier to prevent bleeding without affording antibacterial activity, while infection occurs more often at punctured sites and obstructs the healing of the punctured tissue.…”

“…Further, it increases the risk of local or systemic complications (e.g., subcutaneous bruises, swelling, nerve damage, and uncontrolled bleeding) in patients suffering from hemophilia, Von Willebrand disease, vitamin K deficiency, rat poisoning, warfarin poisoning, and disseminated intravascular coagulation. 6,7 Recently, a self-sealing hemostatic needle coated with catechol-conjugated chitosan has been reported for antibleeding after tissue puncture via solid-to-gel phase transition of catechol-functionalized chitosan. 8,9 However, the preparation process of hemostatic needles either involved complex modification of polymers or an oxidative preincubation process of 3 days to achieve hemostatic functions.…”

Whole blood multiplex measurements using electrochemical aptamer-based biosensors

“…9,14,15 Using multielectrode devices can be detrimental to the elderly, preterm babies, or hemophiliac patients and can complicate the design of devices requiring multichannel capabilities, which increases their size and cost. [16][17][18][19] Thus, there is yet to be a platform technology that achieves convenient, minimally invasive, multiplex and in body molecular measurements via the use of a single electrode device.…”