The RNA-Binding Protein NELFE Promotes Gastric Cancer Growth and Metastasis Through E2F2

Chen, Changyu; Zheng, Qiang; Pan, Shubo; Chen, Wenzheng; Huang, Jianfeng; Cao, Yi; Tu, Yi; Li, Zhengrong; Yu, Changjun; Jie, Zhigang

doi:10.3389/fonc.2021.677111

Cited by 4 publications

(3 citation statements)

References 35 publications

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“…E2F2 is essential for B-Myb-induced malignant phenotype, and show positively correlation with B-Myb, interacting in colorectal cancer cells to activate ERK and AKT signaling pathways to promote carcinogenesis [ 36 ]. In gastric cancer, reducing the expression level of E2F2 inhibited the proliferation and migration of gastric cancer cells [ 37 ]. All of these genes have been reported to be involved in cancer development, migration, and invasion, and in-depth studies of these genes have the potential to discover novel bladder cancer target molecules.…”

Section: Discussionmentioning

confidence: 99%

RNA-seq reveals novel mechanistic targets of Livin in bladder cancer

et al. 2023

BMC Urol

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Background Bladder cancer is a very common malignancy with a high recurrence rate. The survival of patients with muscle-invasive bladder cancer is poor, and new therapies are needed. Livin has been reported to be upregulated in bladder cancer and influence the proliferation of cancer cells. Materials and methods The Livin gene in human bladder cancer cell line T24 was knocked out, and the differentially expressed genes were identified by RNA-seq and qPCR. Results Livin knockdown affects gene expression and has strong negative effects on some cancer-promoting pathways. Furthermore, combined with bladder cancer clinical sample data downloaded from TCGA and GEO, 2 co-up-regulated genes and 58 co-down-regulated genes were identified and validated, which were associated with cancer proliferation and invasion. Conclusion All these results suggest that Livin plays an important role in bladder cancer and could be a potential anticancer target in clinical therapy.

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Section: Discussionmentioning

confidence: 99%

RNA-seq reveals novel mechanistic targets of Livin in bladder cancer

et al. 2023

BMC Urol

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“…E2F2 has been extensively researched in the past few decades in association with gastric cancer. It has been shown that high E2F2 levels are associated with a poor prognosis [19]. A further function of E2F2 is that it regulates PI3K/Akt/mTOR, which are necessary for cell migration, invasion, and autophagy.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Analysis Based on the Cancer Immunotherapy and Immune Activation of Gastric Cancer Patients

Jiang

2023

Genetics Research

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When it comes to aggressiveness and prognosis, immune cells play an important role in the microenvironment of gastric cancer (GC). Currently, there is no well-established evidence that immune status typing is reliable as a prognostic tool for gastric cancer. This study aimed to develop a genetic signature based on immune status typing for the stratification of gastric cancer risk. TCGA data were used for gene expression and clinical characteristics analysis. A ssGSEA algorithm was applied to type the gastric cancer cohorts. A multivariate and univariate Cox regression and a lasso regression were conducted to determine which genes are associated with gastric cancer prognosis. Finally, we were able to produce a 6-gene prognostic prediction model using immune-related genes. Further analysis revealed that the prognostic prediction model is closely related to the prognosis of patients with GC. Nomograms incorporating genetic signatures and risk factors produced better calibration results. The relationship between the risk score and gastric cancer T stage was also significantly correlated with multiple immune markers related to specific immune cell subsets. According to these results, patients’ outcomes and tumor immune cell infiltration correlate with risk scores. In addition, immune cellular-based genetic signatures can contribute to improved risk stratification for gastric cancer. Clinical decisions regarding immunotherapy and followup can be guided by these features.

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“…E2F2 also had potential modulatory effects on tumor immunity. CIBERSORTx analysis of the proportion of tumor-infiltrating immune cells (TICs) revealed that immune cells are correlated with E2F2 expression, suggesting that E2F2 might be responsible for the preservation of the immunodominant status for gastric cancer ( 68 ).…”

Section: Functions Of E2f2 In Specific Cancer Typesmentioning

confidence: 99%

The role of E2F2 in cancer progression and its value as a therapeutic target

Gao,

Qiao,

Liu

et al. 2024

Front. Immunol.

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The E2F family of transcription factors plays a crucial role in the regulation of cell cycle progression and cell proliferation. Accumulative evidence indicates that aberrant expression or activation of E2F2 is a common phenomenon in malignances. E2F2 has emerged as a key player in the development and progression of various types of tumors. A wealth of research has substantiated that E2F2 could contribute to the enhancement of tumor cell proliferation, angiogenesis, and invasiveness. Moreover, E2F2 exerts its influence on a myriad of cellular processes by engaging with a spectrum of auxiliary factors and downstream targets, including apoptosis and DNA repair. The dysregulation of E2F2 in the context of carcinogenesis may be attributable to a multitude of mechanisms, which encompass modifications in upstream regulatory elements or epigenetic alterations. This review explores the function of E2F2 in cancer progression and both established and emerging therapeutic strategies aiming at targeting this oncogenic pathway, while also providing a strong basis for further research on the biological function and clinical applications of E2F2.

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The RNA-Binding Protein NELFE Promotes Gastric Cancer Growth and Metastasis Through E2F2

Cited by 4 publications

References 35 publications

RNA-seq reveals novel mechanistic targets of Livin in bladder cancer

RNA-seq reveals novel mechanistic targets of Livin in bladder cancer

Comprehensive Analysis Based on the Cancer Immunotherapy and Immune Activation of Gastric Cancer Patients

The role of E2F2 in cancer progression and its value as a therapeutic target

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