The role and mechanism of citrus flavonoids in cardiovascular diseases prevention and treatment

Deng, Ya; Tu, Yali; Lao, Shenghui; Wu, Mengting; Yin, Hantong; Lin-qing, Wang; Liao, Wenzhen

doi:10.1080/10408398.2021.1915745

Cited by 34 publications

(16 citation statements)

References 137 publications

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“…RCT results showed that NMTC combined with butylphthalide softgels helped to reduce brain damage, improve endothelial function, and inhibit IL-17 levels in patients with AIS (Dongyun & Jianwei, 2021). Ginkgobiloba and Puerariae Lobatae Radix in NMTC both contain natural flavonoids, which are strong antioxidants and protect nerve cell membranes from oxygen free radicals, and some forms of flavonoids can be converted into anti-coagulants in the body (Deng et al, 2022). A meta-analysis showed that NMTC improved cerebral circulation, reduced platelet aggregation, improved perfusion of ischemic tissues, regulated blood lipids, and inhibited atherosclerosis (Lijian et al, 2023).…”

Section: Yindanxinnaotong Capsulesmentioning

confidence: 99%

Traditional Chinese medicines treat ischemic stroke and their main bioactive constituents and mechanisms

Fan,

Liu,

Liu

et al. 2023

Phytotherapy Research

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Ischemic stroke (IS) remains one of the leading causes of death and disability in humans. Unfortunately, none of the treatments effectively provide functional benefits to patients with IS, although many do so by targeting different aspects of the ischemic cascade response. The advantages of traditional Chinese medicine (TCM) in preventing and treating IS are obvious in terms of early treatment and global coordination. The efficacy of TCM and its bioactive constituents has been scientifically proven over the past decades. Based on clinical trials, this article provides a review of commonly used TCM patent medicines and herbal decoctions indicated for IS. In addition, this paper also reviews the mechanisms of bioactive constituents in TCM for the treatment of IS in recent years, both domestically and internationally. A comprehensive review of preclinical and clinical studies will hopefully provide new ideas to address the threat of IS.

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Section: Yindanxinnaotong Capsulesmentioning

confidence: 99%

Traditional Chinese medicines treat ischemic stroke and their main bioactive constituents and mechanisms

Fan,

Liu,

Liu

et al. 2023

Phytotherapy Research

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“…[ 6 ] NOB has attracted researchers’ strong attention due to its rich bioactivities, including satisfactory antiinflammatory, hypoglycemic function, antioxidation, and antiinsulin resistance. [ 7 ] NOB has been proved to possess excellent hypoglycemic effects, including improving obesity diabetes, [ 8 ] gestational diabetes, [ 9 ] diabetic nephropathy, [ 10 ] etc. At present, the research on NOB in the field of diabetes mainly focused on the superior hypoglycemic effect with few hypoglycemic mechanisms, especially which based on the gut and intestinal metabolites.…”

Section: Introductionmentioning

confidence: 99%

Hypoglycemic Effect of Nobiletin via Gut Microbiota‐Metabolism Axis on Hyperglycemic Mice

Liao

Zou

et al. 2023

Molecular Nutrition Food Res

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Scope Prediabetes and diabetes are major public health problems worldwide without specific cure currently. Gut microbes have been recognized as one of the vital therapeutic targets for diabetes. The exploration that nobiletin (NOB) whether affects gut microbes provides a scientific basis for its application. Methods and results A hyperglycemia animal model is established using high‐fat‐fed ApoE−/− mice. After 24 weeks of NOB intervention, the level of fasting blood glucose (FBG), glucose tolerance, insulin resistance, and glycosylated serum protein (GSP) are measured. Pancreas integrity is observed by hematoxylin‐eosin (HE) staining and transmission electron microscopy. 16s RNA sequencing and untargeted metabolomics are to determine the changes of intestinal microbial composition and metabolic pathways. The levels of FBG and GSP in hyperglycemic mice are effectively reduced. The secretory function of pancreas is improved. Meanwhile, NOB treatment restored the gut microbial composition and affected metabolic function. Furthermore, NOB treatment regulates the metabolic disorder mainly through lipid metabolism, amino acid metabolism, and Secondary bile acid metabolism, etc. In addition, it is possibly existed mutual promotion between microbe and metabolites. Conclusion NOB probably plays a vital role in the hypoglycemic effect and pancreatic islets protection by improving microbiota composition and gut metabolism.

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“…High dietary intake of bioflavonoids, plant-derived polyphenolic compounds consumed in the diet, has been shown to reduce the risk of cardiovascular mortality, which arouses interest in exploring the underlying mechanism of this preventive effect. [12][13][14] Our previous studies indicated that the bio-flavonoid luteolin, widely distributed in the Chinese herb Flos Chrysanthemi, vegetables, fruits, and nuts, can attenuate myocardial ischemia/reperfusion injury in diabetes through inhibiting oxidative stress. 15,16 Recently, luteolin has been reported to alleviate inorganic mercury-induced kidney injury and sepsis-induced myocardial injury by enhancing autophagy.…”

Section: Introductionmentioning

confidence: 99%

The protection of luteolin against diabetic cardiomyopathy in rats is related to reversing JNK-suppressed autophagy

et al. 2023

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The role and mechanism of citrus flavonoids in cardiovascular diseases prevention and treatment

Cited by 34 publications

References 137 publications

Traditional Chinese medicines treat ischemic stroke and their main bioactive constituents and mechanisms

Traditional Chinese medicines treat ischemic stroke and their main bioactive constituents and mechanisms

Hypoglycemic Effect of Nobiletin via Gut Microbiota‐Metabolism Axis on Hyperglycemic Mice

The protection of luteolin against diabetic cardiomyopathy in rats is related to reversing JNK-suppressed autophagy

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