The role of adaptive T cell immunity in atherosclerosis

Mallat, Ziad; Taleb, Soraya; Ait‐Oufella, Hafid; Tedgui, Alain

doi:10.1194/jlr.r800092-jlr200

Cited by 184 publications

(147 citation statements)

References 49 publications

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“…dcs are a heterogeneous population of bone marrow-derived immune cells that specialize in capturing, processing and presenting antigens to T lymphocytes in order to induce and control immunity (14). dcs are morphologically characterized by the presence of several thin cytoplasmic processes (dendrites) and by large cytoplasmic veils that are continuously extended and retracted (15).…”

Section: Dendritic Cells: Origin and Functionsmentioning

confidence: 99%

The functional role of dendritic cells in atherogenesis (Review)

Puddu

Puddu²,

Cravero³

et al. 2010

Mol Med Rep

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Abstract. accumulating evidence suggests that dendritic cells (dcs) play a crucial role in the generation and progression of atherosclerosis (ATS), a lipid-related immuno-inflammatory disease. dcs have the ability to process and present antigens (mainly oxidized low-density lipoproteins, heat shock proteins and fragments of necrotic or apoptotic cells) to naïve T cells, and the activation of T cells is a key step for the progression of atherosclerotic disease. The existence of some distinct dc subtypes has now become evident. The main categories of dc subsets are the 'conventional or myeloid' and the 'plasmacytoid', which differ in toll-like receptor type and site of expression, pathogens and antigens recognized, and effector cytokines and functions. Studies on the potential impact of dcs in the pathogenesis of aTS may lead to novel therapies to regulate the immunoreactions occurring in atherogenesis. in particular, diltiazem, peroxisome proliferator activated receptor agonists and statins have been shown to protect endothelial cell function by inhibiting dcs, a mechanism that may play a significant role in the prevention of ATS.

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Section: Dendritic Cells: Origin and Functionsmentioning

confidence: 99%

The functional role of dendritic cells in atherogenesis (Review)

Puddu

Puddu²,

Cravero³

et al. 2010

Mol Med Rep

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“…Oxidized LDL, LDL, and heat shock protein 60 (HSP60) activated Th 1 in atherosclerotic plaque as the relevant activating antigen (177)(178)(179). In an atherogenic state, Th 1 produces large amounts of INF-ɤ, resulting in the overexpression of MMPs, the reduction of collagen production, and thinning of the fibrous-cap (180,181). In contrast to Th 1, Tregs can suppress inflammatory responses by various mechanisms (182)(183)(184)(185)(186).…”

Section: Inflammationmentioning

confidence: 99%

Stabilization of high-risk plaques

Takata¹,

Imaizumi²,

Zhang³

et al. 2016

Cardiovasc. Diagn. Ther.

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“…Antigen presentation to T-cells promotes generation of antigen specific pathogenic and / or regulatory T-cells. 43 Macrophages are important cells in mediating inflammation, innate and adaptive immune responses all of which are important in atherogenesis. 44 Macrophages take up modified lipoproteins through scavenger receptors.…”

Section: Immunity and Atherosclerosismentioning

confidence: 99%

“…41,42 Dendritic cells play an important role as specialized antigen presenting cells required for the activation of naive T-cells and the development of antigen specific Tcell mediated immune responses. 43 Potential candidate T-cell antigens in atherosclerosis involve both autoantigens as well as microbial derived antigens (Table 2). Antigen presentation to T-cells promotes generation of antigen specific pathogenic and / or regulatory T-cells.…”

Section: Immunity and Atherosclerosismentioning

confidence: 99%

Biochemical mechanisms underlying atherogenesis

PVLN¹,

VS²

2012

JCSR

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Atherosclerosis remains one of the major causes of death and premature disability in developed countries. Though atherosclerosis was formerly considered a bland lipid storage disease, substantial advances in basic and experimental sciences have illuminated the role of endothelium, inflammation and immune mechanisms in its pathogenesis. Current concept of atherosclerosis is that of a dynamic and progressive disease arising from injury to endothelium, also known as endothelial dysfunction and an inflammatory response to that injury. The lesions of atherosclerosis occur principally in large and medium sized arteries. Atherosclerosis affects various regions of the circulation preferentially and can lead to ischemia of heart, brain or extremities resulting in infarction. This produces distinct clinical manifestations depending on the vessel involved. Several predisposing factors to cardiovascular diseases such as diabetes mellitus, hypertension, obesity, infections act as triggers to the development of atherosclerosis by causing endothelial dysfunction and/or promoting inflammatory response. The evolution of pathogenetic mechanisms has passed through various directions such as oxidative stress, inflammation and immune responses. It is now known that all these are not acting independently but are interrelated and getting unified in the current concept of atherogenesis. The following discussion aims at providing an insight into these developments which can help in a better comprehension of the disease and management of its clinical complications.

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The role of adaptive T cell immunity in atherosclerosis

Cited by 184 publications

References 49 publications

The functional role of dendritic cells in atherogenesis (Review)

The functional role of dendritic cells in atherogenesis (Review)

Stabilization of high-risk plaques

Biochemical mechanisms underlying atherogenesis

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