The role of adiponectin in periodontitis: Current state and future prospects

Wang, Zhaodan; Chen, Zehao; Fang, Fuchun; Qiu, Wei

doi:10.1016/j.biopha.2021.111358

Cited by 23 publications

(25 citation statements)

References 91 publications

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“…Several studies have reported association between leptin and periodontitis. 19,20 Serio et al demonstrated presence of leptin within healthy and inflamed gingiva. 6 The leptin concentration was found highest in healthy gingiva in the solubilised gingival biopsies.…”

Section: Discussionmentioning

confidence: 99%

Role of nonsurgical periodontal therapy on leptin levels and total antioxidant capacity in chronic generalised periodontitis patients – A clinical trial

Nisha

Shivamallu

Prashant

et al. 2022

Journal of Oral Biology and Craniofacial Research

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Section: Discussionmentioning

confidence: 99%

Role of nonsurgical periodontal therapy on leptin levels and total antioxidant capacity in chronic generalised periodontitis patients – A clinical trial

Nisha

Shivamallu

Prashant

et al. 2022

Journal of Oral Biology and Craniofacial Research

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“…Second, there may be a slight sample overlap in our study, which can generate the bias to some extent. Finally, the GWAS summary level data for CA we used was sampled from serum, and although adiponectin is predominantly distributed in plasma [ 14 , 58 , 59 ], a minor proportion was also present in synovial fluid, so the results of this study only focus on adiponectin levels in serum and ignore adiponectin in synovial fluid.…”

Section: Discussionmentioning

confidence: 99%

No Evidence to Support a Causal Relationship between Circulating Adiponectin Levels and Ankylosing Spondylitis: A Bidirectional Two-Sample Mendelian Randomization Study

Xie

Yang

et al. 2022

Genes

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Based on previous observational studies, the causal association between circulating adiponectin (CA) levels and ankylosing spondylitis (AS) risk remains unclear. Therefore, this study aims to investigate whether CA levels are related to the risk of AS. We carried out a bidirectional two-sample Mendelian randomization (MR) analysis to examine the causal correlation between CA levels and AS via published genome-wide association study (GWAS) datasets. Single-nucleotide polymorphisms (SNPs) related to CA levels were derived from a large GWAS that included 39,883 individuals of European descent. SNPs related to AS were obtained from the FinnGen consortium (2252 cases and 227,338 controls). The random-effects inverse variance weighted (IVW) method was the primary method utilized in our research. We also used four complementary approaches to improve the dependability of this study (MR–Egger regression, Weighted median, Weighted mode, and Simple mode). Random-effects IVW (odds ratio [OR], 1.00; 95% confidence interval [CI], 0.79–1.27, p = 0.984) and four complementary methods all indicated that genetically predicted CA levels were not causally related to the risk of AS. In reverse MR analysis, there is little evidence to support the genetic causality between the risk of AS and CA levels.

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“…Periodontitis causes progressive destruction of the periodontal support tissue, including alveolar bone resorption, attachment loss, and matrix destruction [ 28 ]. To uncover the effect of DPSCs on the treatment of periodontal regeneration, DPSCs or sheets were directly transplanted to periodontal defects in minipigs.…”

Section: Dpsc Sheets Applicationsmentioning

confidence: 99%

Dental-derived mesenchymal stem cell sheets: a prospective tissue engineering for regenerative medicine

Chen

Huang

et al. 2022

Stem Cell Res Ther

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Stem cells transplantation is the main method of tissue engineering regeneration treatment, the viability and therapeutic efficiency are limited. Scaffold materials also play an important role in tissue engineering, whereas there are still many limitations, such as rejection and toxic side effects caused by scaffold materials. Cell sheet engineering is a scaffold-free tissue technology, which avoids the side effects of traditional scaffolds and maximizes the function of stem cells. It is increasingly being used in the field of tissue regenerative medicine. Dental-derived mesenchymal stem cells (DMSCs) are multipotent cells that exist in various dental tissues and can be used in stem cell-based therapy, which is impactful in regenerative medicine. Emerging evidences show that cell sheets derived from DMSCs have better effects in the field of regenerative medicine applications. Extracellular matrix (ECM) is the main component of cell sheets, which is a dynamic repository of signalling biological molecules and has a variety of biological functions and may play an important role in the application of cell sheets. In this review, we summarized the application status, mechanisms that sheets and ECM may play and future prospect of DMSC sheets on regeneration medicine.

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The role of adiponectin in periodontitis: Current state and future prospects

Cited by 23 publications

References 91 publications

Role of nonsurgical periodontal therapy on leptin levels and total antioxidant capacity in chronic generalised periodontitis patients – A clinical trial

Role of nonsurgical periodontal therapy on leptin levels and total antioxidant capacity in chronic generalised periodontitis patients – A clinical trial

No Evidence to Support a Causal Relationship between Circulating Adiponectin Levels and Ankylosing Spondylitis: A Bidirectional Two-Sample Mendelian Randomization Study

Dental-derived mesenchymal stem cell sheets: a prospective tissue engineering for regenerative medicine

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