The role of Alix in the proliferation of human glioma cells

Zhao, Chengjin; Ban, Na; Dai, Shirong; Zhang, Xiubing; Zhang, Li; Xu, Peng; Chen, Wenjuan; Sun, Jie; Bao, Zhen; Chang, Hao; Wang, Donglin; Ren, Jianbing

doi:10.1016/j.humpath.2015.09.046

Cited by 6 publications

(4 citation statements)

References 22 publications

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“…Here we identified several genes that may be linked to long-term remission. ALIX (ALG-2-interacting protein X, also known as programmed cell death 6 interacting protein: PDCD6IP) functions within the endosomal sorting complex required for transport (ESCRT) pathway and is involved in endocytosis, multivesicular body biogenesis, membrane repair, apoptosis, and maintenance of tight junction integrity 34,35 . Interestingly, ALIX protein expression is decreased in severe colitis 36 .…”

Section: Discussionmentioning

confidence: 99%

Mucosal microbiota and gene expression are associated with long-term remission after discontinuation of adalimumab in ulcerative colitis

Sakurai

Nishiyama

Sakai

et al. 2020

Sci Rep

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Given that sustained remission is the ultimate treatment goal in the management of patients with ulcerative colitis (UC), the decision to stop anti-tumor necrosis factor (anti-TNF) treatment in UC patients is difficult. The aim of this study was to evaluate mucosal microbiota and gene expression profiles associated with long-term remission after discontinuation of anti-TNF therapy. In nine UC patients who received anti-TNF therapy for 6 months, microbiota isolated from uninflamed mucosae and gene expression in inflamed and uninflamed mucosae were investigated at week 0 and at week 24. At treatment initiation, Fusobacterium sp. and Veillonella dispar were over-represented in the relapse group compared with the non-relapse group. After treatment, Dorea sp. and Lachnospira sp. were over-represented in the non-relapse group. In the relapse group only, a significant shift in gut bacterial community composition was found between week 0 and week 24. Gene expression of ALIX (PDCD6IP) and SLC9A3 was significantly higher in the non-relapse group than in the relapse group. Lastly, we used machine learning methods to identify relevant gene signatures associated with sustained remission. Statistical analyses of microbiota and expression profiles revealed differences between UC patients who did or did not keep remission after the discontinuation of TNF inhibitors. Trial registration: UMIN000020785: Evaluation of adalimumab therapy in mesalazine-resistant or -intolerant ulcerative colitis; an observational study (EARLY study).

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Section: Discussionmentioning

confidence: 99%

Mucosal microbiota and gene expression are associated with long-term remission after discontinuation of adalimumab in ulcerative colitis

Sakurai

Nishiyama

Sakai

et al. 2020

Sci Rep

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“…TDEs are consequently released by the fusion of MVBs with the tumor cell plasma membrane 59 . Studies have reported that most of the key regulators, for example, ESCRT-0 proteins (HRS, STAM1, STAM2) 60 – 62 , ESCRT-I protein TSG101 63 , ESCRT-III proteins (CHMP4A, CHMP4B, CHMP4C) 64 , and accessory protein Alix 65 , are overexpressed and/or hyperactivated in various tumor cells, contributing to the aberrant secretion of TDEs (Fig. 3 ).…”

Section: Tde Biogenesis and Secretionmentioning

confidence: 99%

Targeted inhibition of tumor-derived exosomes as a novel therapeutic option for cancer

Chen

Duan

et al. 2022

Exp Mol Med

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Mounting evidence indicates that tumor-derived exosomes (TDEs) play critical roles in tumor development and progression by regulating components in the tumor microenvironment (TME) in an autocrine or paracrine manner. Moreover, due to their delivery of critical molecules that react to chemotherapy and immunotherapy, TDEs also contribute to tumor drug resistance and impede the effective response of antitumor immunotherapy, thereby leading to poor clinical outcomes. There is a pressing need for the inhibition or removal of TDEs to facilitate the treatment and prognosis of cancer patients. Here, in the present review, we systematically overviewed the current strategies for TDE inhibition and clearance, providing novel insights for future tumor interventions in translational medicine. Moreover, existing challenges and potential prospects for TDE-targeted cancer therapy are also discussed to bridge the gaps between progress and promising applications.

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“…Alix plays a role in the regulation of apoptosis, cell adhesion, cell division, and cytomorphology [ 17 , 18 ]. The overexpression of Alix can promote apoptosis [ 19 , 20 ] or tumor cell proliferation [ 21 ], whereas a truncated form prevents apoptosis [ 19 ]. Numerous studies have linked Alix to the modulation of apoptosis in neurons and neurodegenerative diseases [ 19 , 20 , 22 , 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Interplay of TRIM2 E3 Ubiquitin Ligase and ALIX/ESCRT Complex: Control of Developmental Plasticity During Early Neurogenesis

Lokapally

Neuhaus

Herfurth

et al. 2020

Cells

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Tripartite motif 2 (TRIM2) drives neurite outgrowth and polarization, is involved in axon specification, and confers neuroprotective functions during rapid ischemia. The mechanisms controlling neuronal cell fate determination and differentiation are fundamental for neural development. Here, we show that in Xenopus, trim2 knockdown affects primary neurogenesis and neural progenitor cell survival. Embryos also suffer from severe craniofacial malformation, a reduction in brain volume, and the loss of motor sensory function. Using a high-throughput LC-MS/MS approach with GST-Trim2 as bait, we pulled down ALG-2 interacting protein X (Alix) from Xenopus embryonic lysates. We demonstrate that the expression of trim2/TRIM2 and alix/ALIX overlap during larval development and on a cellular level in cell culture. Interestingly, trim2 morphants showed a clustering and apoptosis of neural progenitors, which are phenotypic hallmarks that are also observed in Alix KO mice. Therefore, we propose that the interaction of Alix and Trim2 plays a key role in the determination and differentiation of neural progenitors via the modulation of cell proliferation/apoptosis during neurogenesis.

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The role of Alix in the proliferation of human glioma cells

Cited by 6 publications

References 22 publications

Mucosal microbiota and gene expression are associated with long-term remission after discontinuation of adalimumab in ulcerative colitis

Mucosal microbiota and gene expression are associated with long-term remission after discontinuation of adalimumab in ulcerative colitis

Targeted inhibition of tumor-derived exosomes as a novel therapeutic option for cancer

Interplay of TRIM2 E3 Ubiquitin Ligase and ALIX/ESCRT Complex: Control of Developmental Plasticity During Early Neurogenesis

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