The Role of Allergy in Otologic Disease

Yang, Bishan; Brook, Christopher

doi:10.1016/j.otc.2017.08.005

Cited by 17 publications

(17 citation statements)

References 67 publications

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“…An allergy is defined as a condition caused by hypersensitivity of the immune system to typically harmless substances in the environment, and as we commented previously, the greater susceptibility of the inner ear to certain aberrant reactions of the immune system supports this theory. 14 Animal studies have reported the development of EH after environmental antigen exposure. 39 In addition, another study showed an improvement in the control of symptoms like vertigo in patients with associated environmental or food allergies, after the establishment of a specific allergy treatment.…”

Section: Allergy-related MDmentioning

confidence: 99%

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Current Understanding and Clinical Management of Meniere's Disease: A Systematic Review

Pérez-Carpena

Lopez-Escamez

2019

Semin Neurol

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Meniere's disease (MD) is a set of uncommon disorders with core phenotype of tinnitus, episodic vertigo, and sensorineural hearing loss. MD shows a genetic predisposition and a family history is found in 10% cases, with an autosomal dominant inheritance pattern. It is a multifactorial condition whose onset and development are triggered by the combined effect of genetic and environmental factors. Histopathological studies have associated MD with the accumulation of endolymph in the cochlea and the vestibular organs. However, endolymphatic hydrops does not fully explain the persistence of tinnitus, hearing loss progression, or the frequency of vertigo attacks.There are several comorbidities associated with MD, such as migraine, anxiety, autoimmune, and autoinflammatory disorders, adding more complexity to the phenotype. This “extended phenotype” can make the diagnosis and clinical management more complex, but it could also lead to a better characterization, understanding, and treatment of MD patients.We have conducted a systematic review on MD to update current knowledge, focusing on its mechanisms, diagnosis, comorbidities, and practical management.

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Section: Allergy-related MDmentioning

confidence: 99%

“…Clinical improvement in MD patients with allergy has been observed after treatment of the allergy. 14 Several studies have reported a higher prevalence of migraine in MD. 15 MD has also been related to migraine in several studies, and a possible common etiology has been suggested.…”

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confidence: 99%

Current Understanding and Clinical Management of Meniere's Disease: A Systematic Review

Pérez-Carpena

Lopez-Escamez

2019

Semin Neurol

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“…it is said that the inflammation mediators found in ear exudates from allergic patients are similar to those found in the late phase of an allergic response. Moreover, the mucosa found in middle ear emerges from the same ectoderm as the rest of the mucosa of the respiratory system [4]. this means the middle ear is capable of an allergic response and may be treated as a compartment of the "united airway" [4,5].…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, the mucosa found in middle ear emerges from the same ectoderm as the rest of the mucosa of the respiratory system [4]. this means the middle ear is capable of an allergic response and may be treated as a compartment of the "united airway" [4,5]. summarizing, it behaves similarly to any other part of the respiratory tract in allergic patients, where the inflammatory response leads to swelling and obstruction [5].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of allergy in children with adenoid hypertrophy and otitis media with effusion admitted to the Department of Pediatric Otolaryngology in Poznan

Adamczyk¹,

Pucher²,

Magdalena³

et al. 2018

fmpcr

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Background. allergic diseases are the most common chronic illnesses in children. it is said that patients with allergy more often suffer from adenoid hypertrophy and otitis media with effusion than non-allergic patients. Objectives. to estabilish the prevalence of allergy in children with adenoid hypertrophy with or without otitis media with effusion (oMe) admitted to the department of Pediatric otolaryngology in Poznan between 05.2017 and 05.2018 and to check if allergy affects the incidence of oMe and adenoid hypertrophy. Material and methods. each patient admitted for adenoidecomy or tympanostomy tube placement or both was carefully interviewed to check if they suffered from allergic diseases. in every patient with oMe, a preoperative tympanometry and pure tone audiogram or otoacoustic emission was performed. the data was analyzed statistically. the chi-square test was used, with a p value < 0.05. Results. 153 patients aged 2 to 16 years (68 girls and 85 boys) were admitted to the Poznan Pediatric otolaryngology department between 05.2017 and 05.2018. the children were divided in to three age subgroups. 16.9% of children undergoing adenoidectomy and 17.4% of children undergoing adenoidectomy with tympanostomy tube placement suffered from allergic disease. allergy did not affect the incidence of oMe or adenoid hypertrophy, but this finding was not statistically significant. oMe diagnosis and ear tube placement was statistically more often seen in boys (p = 0.02, chi 2 = 5.39). Conclusions. Prevalence of allergy was higher in boys and they had more often ear tubes placement performed. that difference was statistically significant. allergy in our study group did not influence the prevalence of oMe, nor the adenoid hypertrophy.

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“…In addition, several studies have highlighted the potential role of allergy in MD. [42][43][44][45] The patients in our study were not evaluated for allergies; however, it remains a possible consideration in the treatment of MD.…”

Section: Discussionmentioning

confidence: 99%

A comparison of endolymphatic shunt surgery and intratympanic gentamicin for meniere's disease

et al. 2019

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Objective To report audiovestibular outcomes following endolymphatic shunt surgery (ELS) and intratympanic gentamicin injections (ITG) in patients with Meniere's disease (MD). Study Design Retrospective matched cohort study Methods Patients with MD refractory to medical management between 2004 and 2017 were reviewed: 44 patients underwent ELS and had outcomes available, while 27 patients underwent ITG and had outcomes available. Mean follow‐up durations for the ELS and ITG groups were 39.1 and 43.3 months, respectively. Twenty‐six patients from the ELS group and 24 patients from the ITG group were then included in a pretreatment hearing‐ and age‐matched analysis. Main outcome measures were successful control of vertigo, pure‐tone average (PTA; 0.5, 1, 2 and 4 kHz), word recognition score (WRS), and treatment complications. Results A matched analysis showed vertigo control rates of 73.1% in the ELS group and 66.8% in the ITG group, which were not significantly different (P = .760). The change in PTA following treatment was statistically similar between the ELS group (6.2 dB) and ITG group (4.6 dB) (P = .521), while the change in WRS for the ELS group (+3.9 %) was significantly more favorable than the ITG group (‐13.6 %) (P = .046). Chronic post‐treatment unsteadiness was reported in 25.0% of the ITG group and was not encountered in the ELS group (P = .009). Conclusion ELS provided successful vertigo control at least as well as ITG with a lower incidence of audiovestibular complications. Level of Evidence 4 Laryngoscope, 130:2455–2460, 2020

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The Role of Allergy in Otologic Disease

Cited by 17 publications

References 67 publications

Current Understanding and Clinical Management of Meniere's Disease: A Systematic Review

Current Understanding and Clinical Management of Meniere's Disease: A Systematic Review

Prevalence of allergy in children with adenoid hypertrophy and otitis media with effusion admitted to the Department of Pediatric Otolaryngology in Poznan

A comparison of endolymphatic shunt surgery and intratympanic gentamicin for meniere's disease

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